Disease Models & Behavioral Testing Research

Explore animal models by disease area, compare behavioral testing approaches, and find the right equipment for your protocol.

Browse by Disease Area

Each guide maps validated animal models to behavioral testing protocols and the equipment you need to run them. Select a disease area to compare transgenic and pharmacological models, view phenotype timelines, and build your testing battery.

Alzheimer's Disease4 models

Compare 5xFAD, APP/PS1, 3xTg-AD, and scopolamine models. Phenotype timelines, validated behavioral batteries, and equipment recommendations for Alzheimer's preclinical research.

Models: 5xFAD, APP/PS1, 3xTg-AD, Scopolamine-Induced
Key Equipment: Morris Water Maze, Barnes Maze, Y-Maze
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Parkinson's Disease4 models

Compare MPTP, 6-OHDA, alpha-synuclein PFF, and rotenone models. Dopaminergic lesion timelines, motor testing batteries, and equipment recommendations for Parkinson's preclinical research.

Models: MPTP, 6-OHDA, α-Synuclein PFF, Rotenone
Key Equipment: Rotarod Test, Pole Test, Balance Beam Test
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Depression4 models

Compare CUMS, chronic social defeat, learned helplessness, and corticosterone models. Anhedonia and despair timelines, validated behavioral batteries, and equipment recommendations for depression research.

Models: CUMS, CSDS, Learned Helplessness, Chronic Corticosterone
Key Equipment: Forced Swim Test, Tail Suspension Test, Sucrose Preference Test
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Anxiety Disorders4 models

Compare pharmacological, chronic stress, PTSD, and innate fear models. Anxiety assay protocols, validated behavioral batteries, and equipment recommendations for anxiety and PTSD research.

Models: Diazepam Validation, Chronic Corticosterone, SPS (PTSD), Predator Odor
Key Equipment: Elevated Plus Maze, Light-Dark Box, Zero Maze
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Stroke4 models

Compare MCAO, photothrombotic, endothelin-1, and global ischemia models. Infarct timelines, motor and cognitive recovery testing, and equipment recommendations for stroke preclinical research.

Models: MCAO, Photothrombotic, Endothelin-1, Global Ischemia
Key Equipment: Rotarod Test, Balance Beam Test, Grip Strength Test
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Epilepsy4 models

Compare pilocarpine, PTZ kindling, kainic acid, and 6-Hz corneal stimulation models for epilepsy research with validated behavioral test batteries.

Models: Pilocarpine SE, PTZ Kindling, Kainic Acid, 6-Hz Corneal Stimulation
Key Equipment: Open Field Test, Rotarod Test, Morris Water Maze
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Addiction4 models

Compare CPP, IV self-administration, locomotor sensitization, and two-bottle choice models for addiction research with validated behavioral test batteries.

Models: Conditioned Place Preference, IV Self-Administration, Locomotor Sensitization, Two-Bottle Choice
Key Equipment: Operant Conditioning, Self Administration Chamber, Open Field Test
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Traumatic Brain Injury4 models

Compare CCI, weight drop, fluid percussion, and blast TBI models with validated behavioral test batteries for cognitive and motor outcome assessment.

Models: CCI, Weight Drop, Lateral FPI, Blast Injury
Key Equipment: Morris Water Maze, Barnes Maze, Rotarod Test
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Pain & Nociception4 models

Compare CFA inflammatory, SNI neuropathic, formalin, and hot plate pain models. Pain onset timelines, behavioral testing batteries, and equipment recommendations for nociception research.

Models: CFA Inflammatory Pain, SNI (Spared Nerve Injury), Formalin Test, Hot Plate Test
Key Equipment: Open Field Test, Elevated Plus Maze, Grip Strength Test
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Autism Spectrum Disorder4 models

Compare BTBR, VPA, Shank3 KO, and maternal immune activation models for autism research. Social deficit profiles, repetitive behavior quantification, and equipment recommendations for ASD studies.

Models: BTBR T+Itpr3tf/J, VPA (Valproic Acid), Shank3 KO, MIA (Maternal Immune Activation)
Key Equipment: Social Interaction Test, Open Field Test, Novel Object Recognition
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Schizophrenia4 models

Compare MK-801, chronic PCP, poly(I:C) MIA, and DISC1 models for schizophrenia research. Positive, negative, and cognitive symptom profiles, PPI testing, and equipment recommendations for preclinical psychiatry.

Models: MK-801 (Dizocilpine), PCP (Phencyclidine) Chronic, Poly(I:C) MIA, DISC1
Key Equipment: Acoustic Startle Chamber, Open Field Test, Social Interaction Test
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Huntington's Disease4 models

Compare R6/2, YAC128, BACHD, and 3-NP models for Huntington's research. Motor and cognitive phenotype timelines, validated behavioral batteries, and equipment recommendations for HD preclinical studies.

Models: R6/2, YAC128, BACHD, 3-NP
Key Equipment: Rotarod Test, Grip Strength Test, Open Field Test
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Obesity & Metabolic Disease4 models

Compare ob/ob, db/db, DIO, and MC4R KO models for obesity and metabolic research. Metabolic phenotype timelines, behavioral comorbidity assessments, and equipment recommendations for metabolic disease studies.

Models: ob/ob, db/db, DIO, MC4R KO
Key Equipment: Open Field Test, Rotarod Test, Novel Object Recognition
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Multiple Sclerosis4 models

Compare EAE (MOG and PLP), cuprizone, and Theiler's virus models for MS research. Demyelination and remyelination timelines, motor deficit assessments, and equipment recommendations for multiple sclerosis preclinical studies.

Models: EAE (MOG35-55), EAE (PLP139-151), Cuprizone, TMEV
Key Equipment: Rotarod Test, Grip Strength Test, Open Field Test
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Additional disease model guides are in development. Contact our team for protocol guidance on your specific research area.

Looking for histology workflows instead of disease models? Explore the pathology guide hub for H&E protocols and microtome selection guidance.