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Jaspreet Singh Grewal

Mastering the Microtome
Laboratory TechniquesProtocolsScience
April 20, 2021

The Cryostat-Microtome

A Glimpse into the History of a Cryostat A Cryostat is a versatile and high-quality machine that generates low temperatures for tissue sectioning. The word “Cryostat” originates from two separate Greek words “Kryos”, meaning cold, and “stat”, meaning stable. Sir James Dewar, Scottish Physicist, and Chemist are credited for the…
Laboratory TechniquesProtocolsScience
April 13, 2020

Biomolecular NMR Spectroscopy

The information about the structure, interactions, and dynamics of biomolecules (protein, DNA, and RNA) is essential for understanding cellular processes. This knowledge is deconvolved by scientists and used in elucidating cellular mechanisms for finding cures for human diseases. The pharmaceutical industry, for example, uses this structural information to improve on…
Laboratory TechniquesScience
February 24, 2020

Spin-Spin coupling in NMR

The structure of a molecule can be predicted using NMR spectroscopy. However, the interpretation of the signals in an NMR spectrum relies on several factors. One of the factors affecting the location of the peaks in an NMR spectrum is Chemical shift. The location of the peaks is important in…
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