The Horizontal Ladder test is a motor and coordination test for evaluating skilled walking for mice and rats. Steps are counted and classified as either correct/functional paw placement, a slip, or a miss. Fore & hind-limb coordination can be assessed further by removing individual ladder rungs to evaluate how the rodent targets individual rungs.
The animals are required to walk on a horizontal rung ladder spontaneously with varied spacing between rungs. The MazeEngineers horizontal ladder allows for the removal of individual rungs. Flexibly made to clamp to end plates to allow for aversive or rewarded locomotion. Clear walls allow for easy video recording.
Sevoflurane: (2,2,2-trifluoro-1-(trifluoromethyl) ethyl ether) Halogenated ether that is a sweet smelling, non-flammable fully fluorinated methyl isopropyl ether and has a molecular weight of 200.
While very similar, isoflurane and sevoflurane have slightly different effects and mechanisms of action, even though the anesthetic result is nearly identical.
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