The elevated plus maze test is one of the most widely used tests for measuring anxiety-like behavior. The test is based on the natural aversion of mice for open and elevated areas, as well as on their natural spontaneous exploratory behavior in novel environments. This test has a strong validity profile for anxiolytic drug validation and screening. All open arms include 1cm high end plates to ensure the mice do not fall off the maze during exploration.
Sevoflurane: (2,2,2-trifluoro-1-(trifluoromethyl) ethyl ether) Halogenated ether that is a sweet smelling, non-flammable fully fluorinated methyl isopropyl ether and has a molecular weight of 200.
While very similar, isoflurane and sevoflurane have slightly different effects and mechanisms of action, even though the anesthetic result is nearly identical.
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Ferret Restrainers are constructed using optical quality clear acrylic, formed black plastic nose cone with an acetal locking slide. The restraining cylinder can be rotated as needed to provide complete access to the animal. The restrainers are mounted on a white acrylic base plate with suction cup feet to guarantee reliable stability during testing procedures.