- The conditioned place preference (CPP) is a widely used behavioral model which can evaluate the motivational properties such as the rewarding and aversive effects of drugs and natural substances as well.
- A conditioned place preference (CPP) is said to occur if the animals spend considerably more time in the drug-paired compartment than the vehicle-paired compartment.
- Rossi and Reid developed the concept of drug-paired conditioning to measure drug induce affective state (approach or avoidance behavior) as a measure of the rewarding properties of drug substances.
- In CPP, the primary stimulus (drug) serves as an unconditioned stimulus (UCS). When it is paired with a secondary stimulus (visual or tactile cue) which acts as a conditioned stimulus (CSS), an approaching or aversive behavior for the paired environment is elicited
- CPP continues to be very popular because of its numerous applications.
- Classically, the CPP apparatus is of two types, namely the two-chamber design or three-chamber design.
- The two major experimental designs used to condition animals under the influence of drugs or natural reinforcers are called the Biased and Unbiased experimental designs.
- CPP task, whether biased or unbiased follows the timeline of Pre-test, Conditioning, and Testing Phase.
