The virtual reality environment can be created as per the need of the experiment. In the Simian version multiple environments can be configured.
The Morris Water Maze (MWM) is a widely used behavioral task developed by Richard G. Morris in the year 1981 as a response to the Radial Arm Maze (RAM). As opposed to the Radial Arm Maze, the Morris Water Maze doesn’t provide the subject with a choice point. Further, the task utilizes the fear of drowning to motivate the subject to learn the location of the escape platform quickly. The navigational task is effective in the assessment of spatial learning, and over the course of years has seen modifications and adaptations such as the Water T-Maze, the Water Y-Maze, and the Water RAM.
Open Field test is a popular protocol used to assess exploratory behavior and anxiety. Thigmotaxis in the open field is used to evaluate anxiolytic, anxiogenic and even non-pharmacological treatments. Ambulation is the most common behavior studied with this maze, but others such as latency or rearing can also be measured. In addition, objects can be added for a modification similar to the novel object recognition field.
Walls can be both opaque or clear. We recommend that clear walls are used for measurements of anxiety, while opaque walls are used if assessments include novel object recognition.