Radial Arm Maze – Conduct Science

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The traditional eight radial arm maze has many variants that allow mice, rats, and even primates to display their spatial working memory for the arms that they have visited by avoiding re-entry.

Typically, they do so by relying on their memory for the spatial location of visited arms relative to extra maze landmarks in the testing environment. Extramaze and intramaze cues are key to this process.

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Description

The Radial Arm Maze is extensively used to test spatial learning and memory.
RAM task asks animals to retrieve food rewards at the end of each of eight arms without visiting an arm more than once.
Different groups have adapted this maze in order to collect data regarding working or reference memory, and there are many modifications available, both regarding experimental protocol and data analysis.
Animals in control groups show rapid learning as they remember the location of the arms from which they have retrieved the food reward, while in comparison, animals as disease models of neurodegenerative disorders or brain injuries show a much slower learning curve with lower memory scores.