Open Field test is a popular protocol used to assess exploratory behavior and anxiety. Thigmotaxis in the open field is used to evaluate anxiolytic, anxiogenic and even non-pharmacological treatments. Ambulation is the most common behavior studied with this maze, but others such as latency or rearing can also be measured. In addition, objects can be added for a modification similar to the novel object recognition field.
Walls can be both opaque or clear. We recommend that clear walls are used for measurements of anxiety, while opaque walls are used if assessments include novel object recognition.
The Weight Drop TBI apparatus generally consists of two main parts: the U-shaped Plexiglas box and a collection sponge.
The typical weight drop mTBI equipment consists of a U-shaped Plexiglas stand, a plastic guide tube, brass weights, clamp stand, fishing line, and a collection sponge. The lightly anesthetized rodent is placed supine on a scored tin foil with its head directly in the pathway of the falling weight.
ConductScience offers the Weight Drop TBI apparatus.
Flat Bottom Restrainers are manufactured from perspex cylinders mounted on a flat black perspex base. The restrainers give access through both extremes, by opening the respective tilting door that is fixed by a screw at the upper part of the restrainer. Rodents can be immobilised by sliding the doors along the restrainer. A slot in the base of the door allows for the whole tail to be available for the pulse transducer and cuff installation, the i.v. drug administration or blood extraction.
The easy operation of the doors and its disposition on the extremes of the restrainer makes the manipulation of the animal convenient and avoids the animal to be dragged backwards, protecting it from injuries.