Weight Drop TBI models are used to replicating focal cerebral contusions as well as traumatic, diffuse brain injury by axonal damage. Attach a metal loop to the top end of the desired weight allowing the fishing line to be fastened to the weight. The plastic guide tube is held in place with a clamp stand and positioned above the scored tin foil. The fishing line is then attached through the metal loop to the weight ensuring that the bottom of the weight hangs freely over the scored tin foil. The fishing line is then connected to the clamp stand, and the weight is drawn up through the plastic guide tube with the fishing line and secured in its position with an Allen key pin.
The elevated plus maze test is one of the most widely used tests for measuring anxiety-like behavior. The test is based on the natural aversion of mice for open and elevated areas, as well as on their natural spontaneous exploratory behavior in novel environments. This test has a strong validity profile for anxiolytic drug validation and screening. All open arms include 1cm high end plates to ensure the mice do not fall off the maze during exploration.
Oxygen Flowmeter is used to accurately control the gas flow rate. The flowmeter mounting plate and fixing screws can be added to the RWD large and small animal anesthesia machine fixed bracket to control the air source input flow rate of the RWD anesthesia machine.
And with the international standard ISO connector, the lower end is connected with an 8mm PVC pipe or silicone tube for gas source input, and the upper end is connected to the evaporator through a short section of 6mm silicone tube.
In addition, the oxygen flow meter and the laughing gas flow meter can also be used in parallel. After the oxygen and the laughing gas are mixed, they are mixed with isoflurane or sevoflurane through the evaporator to output mixed anesthetic gas to achieve better anesthesia and analgesia.