The conditioned place preference chamber is a paradigm widely used to explore the reinforcing effects of natural and pharmacological stimuli, including drugs of addiction. Combinations of floor and wall cues are available
In this variant, subjects are allowed to freely move between a compartment in which they were conditioned with either drug cues or neutral cues. The wall cues a (comes with a maze) provide visual reinforcement
This dual-chamber place preference allows for biased and unbiased conditioned place preference testing. A removable door (not shown) allows isolation into one compartment of the apparatus of the animal. Preference testing is then done by removing the door to allow the mouse to freely explore between the two compartments (as seen in the image)
Visual pattern inserts are sandwiched between the clear interior layer and the outer grey layer. These visual pattern inserts do not interact with the mouse directly, preserving the life of the apparatus.
OptionalStanding Inserts (visualized) is for spatial place preference procedures. Please request separately
Scavenging machines are used in the collection and removal of waste anesthetic gases (WAGs) vented during the anesthetization processes. These systems comprise collection devices, interfaces, and disposal systems. Scavenging machines also help monitor the gases and prevent barotrauma to the subject resulting from a change in incoming and outgoing gas flow.
The Morris Water Maze is a widely used behavioral task in neuroscience for studying spatial learning and memory. This test is based on the fact that an animal will try to escape a stressful situation or stimulus, which in this case is a large pool of water. The pool contains a small platform, either visible above the water level, or just below the surface of the water. This small platform allows the animals to escape the water and allows them to stand without the stress of swimming and is designed with a mesh or grooved material that allows for easy handling. Pre-training occurs by introducing the location of the escape platform and using a platform that is visible above the water surface. On the following days, the actual test is performed, in which the platform is hidden beneath the water surface. To escape swimming in the water, the animal must remember the location of the escape platform using visual cues in the testing area, which requires the use of hippocampal-dependent spatial reference memory, and this ability to remember the location of the platform can be affected by the administration of certain drugs or disease models.
The MWM was first used by Richard Morris at the University of St. Andrews in Scotland in the early 1980s. Since then, it has become one of the most widely used tools in behavioral neuroscience because of its ease of use and training, its many variations, and its ability to test various areas of brain function. Morris published a series of papers describing the maze and its evaluation of hippocampal-dependent learning over several years (Morris 1981, Morris 1982, Morris 1984, Morris 1986). The maze also gained popularity when it was used by Ian Whishaw’s group in Canada (Kolb et al. 1982, Kolb et al. 1983). Since these initial papers, the maze has been used to study various disease models, including endocrine abnormalities, strokes, Alzheimer’s disease, other neurodegenerative diseases, and their effects on learning and memory (Brandeis et al. 1989).
The Microdrill Holder fixes the hand-held cranial drill to the operating arm of the locator controlling the drilling depth through the lifting of the operating arm. With this, the procedure is simple and accurate to avoid damages to the animal’s brain tissue or excessive drilling.
The holding range is 14.5mm.
Conduct Science offers Microdrill Holder and Microdrill