Rodent grip is a widely used apparatus to evaluate motor function. The MazeEngineers Grip strength apparatus uses both small and large grip plates to match your strain. Our apparatus measures tensile force and easily outputs mean values.
The instrument has an error value elimination function, which can eliminate operational errors in time, eliminate false values and improve the authenticity of the data. The instrument can read instrument data online with a PC
Price & Dimensions
- Gripping plate area: mouse 20×20 cm and rat 25x25cm
- stainless steel, detachable gripping plate
- Power supply voltage: AC 190V-230V 50HZ
- Power: 20W
The Grip Strength task is used in the assessment of neuromuscular function and muscular strength. The task measures these attributes by sensing the peak amount of force that is required to make the subject release its grip. The test is part of the functional observational battery (FOB) to examine neurobehavioral toxicity. Impairments of muscular strength and functions can result from neurodegenerative disorders such as Parkinson’s disease, clinical conditions such as motor neuron diseases, dietary deficiencies or injuries.
The Grip Strength task is performed by gently lifting the subject by its tail and allowing it to grab on to the grip plate. The subject is then pulled until it releases its grip. The force required to make the subject lose its grip is used as a measure of grip strength.
Apparatus & Equipment
Grip Strength apparatus consists of a baseplate, a trapezoidal stainless-steel grip, and a force sensor. The sensor is connected to a computer to record the data. The apparatus comes with two size grip plates, large and small, to be used with different animals.
Clean the apparatus before and after every trial. To measure grip strength, gently lift the subject by the tail such that its forepaws can grasp on to the steel grip. Gently pull the subject backward by the tail until it releases its grip. Allow at least one-minute resting period in between trials. Perform at least 3 trials per subject.
Evaluation of grip strength in obese Wistar rats
Coradinia et al., 2015 assessed functionality of monosodium glutamate (MSG) induced obese Wistar rats. Subjects were grouped as MSG-treated, MSG-treated with right median nerve compression, and MSG-treated with injury and treated with swimming overload. A counter control group for each of the MSG-treated group was also used. The group with swimming treatment received progressive durations of treatment (20, 30 and 40 minutes) for three weeks. Subjects were then tested on days 3, 7, 14 and 21 postoperative for muscular grip strength. It was observed that control and the obese group showed better grip than the other groups. This suggested that swimming treatment, in MSG-treated and control group, was ineffective in promoting muscle grip strength in compression-induced injury.
Evaluation of effects of Vitamin D deficiency and deletion of Vitamin D receptors
Girgis et al., 2015 studied the effects of Vitamin D deficiency and Vitamin D receptor deletion on the grip strengths of rodents. For their study, they used whole-body Vitamin D receptor knockout (VDRKO) mice and C57BL6 mice that were maintained on rescue chow and vitamin D-deplete diet or a vitamin D-control diet (after 3 weeks on regular chow) respectively. The animals were tested for their grip strength, the results of which revealed that VDRKO mice were significantly weaker than the wild-type controls (grip strength reduced from 43% at 2 months age to 48% at 3 months age). A similar observation was made in the Vitamin D deficient versus replete group. Vitamin D deficient mice showed an increase of grip weakness from 15% to 25%, at 2 months and 3 months of age respectively, in comparison to Vitamin D replete group.
Evaluation of Rapamycin effects on grip strength
Xue et al., 2016 evaluated the effects of Rapamycin on low capacity runner (LCR) rats. Male and female LCR rats were divided into two groups, of which the treatment group received rapamycin containing diet pellets (approximately 2.24mg/kg body weight per day) and the remaining were served a placebo diet for 6 months. On testing for grip strength, the effect of rapamycin was quite evident. Results showed an improvement in grip strength by 13% and 60% in female and male LCR rats, respectively, as compared to the baseline values.
The Grip Strength apparatus is used to measure the subject’s ability to hold on as it is pulled away. The following data can be recorded using the apparatus for Grip Strength task.
- Average tensile force
- Duration of grip
- Tensile force
Strengths & Limitations
Grip Strength test provides a measure of subject’s muscular strength. Changes in grip strength can be conclusive of motor toxicity. The Grip Strength test can be used to assess the effects of different drugs on muscle function and even in evaluating pain. The effects of diet restriction can also be observed using this test. The simplicity of the task makes it ideal and effective in grip strength assessment. The software component of the apparatus helps eliminate operational errors in time, eliminate false values and improve the authenticity of the data. The two different sizes of grip plates allow testing of both rats and mice on the same device.
An important factor in the Grip Strength test is proper placement of the subject. Inexperienced experimenters may have difficulty in placing the subject appropriately on the device. Consistent techniques are vital to achieving accurate data. Factors such as the handling of the subject, diet restrictions, weight, changes in sensory and other nonmotor functions can have a significant impact on the performances. Over-testing the subject may lead to muscle fatigue. Thus, it is important to allow appropriate resting periods between each test.
Summary & Key Points
- Grip Strength is used to assess neuromuscular function and muscular strength.
- Grip strength is measured as the peak amount of force that is required to make the subject release its grip.
- Grip Strength test is part of the functional observational battery (FOB) to examine neurobehavioral toxicity.
- Changes in grip strength are indicative of motor neurotoxicity.
Coradinia JG, Kakihata CM, Kunz RI, Errero TK, Bonfleur ML, Bertolini GR (2015). Article in Portuguese. [Evaluation of grip strength in normal and obese Wistar rats submitted to swimming with overload after median nerve compression]. Rev Bras Reumatol. 55(1):43-7. doi: 10.1016/j.rbr.2014.08.003.
Girgis CM, Cha KM, Houweling PJ, Rao R, Mokbel N, Lin M, Clifton-Bligh RJ, Gunton JE (2015). Vitamin D Receptor Ablation and Vitamin D Deficiency Result in Reduced Grip Strength, Altered Muscle Fibers, and Increased Myostatin in Mice. Calcif Tissue Int. 97(6):602-10. doi: 10.1007/s00223-015-0054-x.
Maurissen JP, Marable BR, Andrus AK, Stebbins KE (2003). Factors affecting grip strength testing. Neurotoxicol Teratol. 25(5):543-53.
Xue QL, Yang H, Li HF, Abadir PM, Burks TN, Koch LG, Britton SL, Carlson J, Chen L, Walston JD, Leng SX (2016). Rapamycin increases grip strength and attenuates age-related decline in maximal running distance in old low capacity runner rats. Aging (Albany NY). 2016 Apr;8(4):769-76. doi: 10.18632/aging.100929.