The application of optogenetics has been rapidly developing since 2010, it’s research field covers several classical experimental animal species, such as flies, mice, rats, zebrafish, primates (Monkey, cynomolgus monkey, rhesus monkey, etc.). These animals generally have the advantages of short developmental and reproductive cycle and easy integration of foreign genes, thus facilitating the introduction of Photosensitive Protein Gene and the screen of the state of expression.