Pediatric Brain Tumor Program

The Pediatric Brain Tumor Portal (PBTP) is organized by the St. Jude Children's Research Hospital Neurobiology and Brain Tumor Program. Investigators have access to specialized resources, such as an integrated support structure for preclinical modeling, including patient-derived xenograft samples. The program consists of clinicians, radiation oncologists, neurobiologists, medicinal chemists, and other research faculty and staff. PBTP features molecular characterization for patient-derived orthotopic xenograft (PDOX) models of pediatric CNS tumors and reflects close to 10 years of effort to generate and extensively characterize in vivo models that faithfully recapitulate pediatric brain cancer diseases. The portal offers visualization tools that allow users to interrogate curated datasets and access models from our library of PDOX for functional studies of tumorigenesis or preclinical testing.