Hallmarks of T-cell exhaustion and antigen experience are absent in multiple myeloma from diagnosis to maintenance therapy

<p>Code and data associated with Shasha et al., "Hallmarks of T-cell exhaustion and antigen experience are absent in multiple myeloma from diagnosis to maintenance therapy" (<a href="https://doi.org/10.1182/blood.2024025655" target="_blank" rel="noopener">https://doi.org/10.1182/blood.2024025655</a>). Description of files below:</p> <p>scRNA-seq_code.tar: Python notebooks for analysis of scRNA-seq data, including import and figure generation</p> <p>adata-rev.h5ad: processed CD8 T cell scRNA-seq data from all patients and samples combined. Includes condensed TCR info (refer to columns 'cdr3' for example; 'chain_id' was determined per batch and can be ignored)</p> <p>ics_tsv_repeat_dat.csv: ICS metadata</p> <p>cytof_ics_repeat_data.tar: normalized ICS tsv and fcs files from all patients and samples</p> <p>ics_repeat_analysis.R: R code for analysis of ICS data</p> <p>cytof_data.tar: CyTOF fcs and txt files (bead normalized and compensated, gated to CD8 T cells)</p> <p>&nbsp;</p>