Identification and single-base gene-editing functional validation of a cis-EPO variant as a genetic proxy for EPO-increasing therapies.

<p>Summary statistics for the genome-wide association study meta-analysis of circulating EPO in 6,127 individuals of European and African American descent. Effect sizes are aligned to allele 1.&nbsp;</p> <p>Description of column names:<br> # Marker &nbsp; &nbsp;- this is the marker name; chromosome:position<br> # Allele1 &nbsp; - the first allele for this marker in the first file where it occurs<br> # Allele2 &nbsp; - the second allele for this marker in the first file where it occurs<br> # Freq1 &nbsp; &nbsp; &nbsp; - weighted average of frequency for allele 1 across all studies<br> # FreqSE &nbsp; &nbsp; &nbsp;- corresponding standard error for allele frequency estimate<br> # MinFreq &nbsp; &nbsp; - minimum frequency for allele 1 across all studies<br> # MaxFreq &nbsp; &nbsp; - maximum frequency for allele 1 across all studies<br> # Effect &nbsp; &nbsp;- overall estimated effect size for allele1<br> # StdErr &nbsp; &nbsp;- overall standard error for effect size estimate<br> # P-value &nbsp; - meta-analysis p-value<br> # Direction - summary of effect direction for each study, with one &#39;+&#39; or &#39;-&#39; per study. Order of the studies is InCHIANTI, BLSA, HealthABC Europeans, PREVEND, HealthABC African Americans<br> # HetISq &nbsp; &nbsp;- I^2 statistic which measures heterogeneity on scale of 0-100%<br> # HetChiSq &nbsp;- chi-squared statistic in simple test of heterogeneity<br> # df &nbsp; &nbsp; &nbsp; &nbsp;- degrees of freedom for heterogeneity statistic<br> # HetPVal &nbsp; - P-value for heterogeneity statistic<br> # TotalSampleSize - overall sample size for that variant in the meta-analysis</p> <p>&nbsp;</p>