Foldseek Multimer

<h1>Rapid and Sensitive Protein Complex Alignment with Foldseek-Multimer</h1> <p>Advances in computational structure prediction will vastly augment the hundreds of thousands of currently-available protein complex structures. Translating these into discoveries requires aligning them, which is computationally prohibitive. Foldseek-Multimer computes complex alignments from compatible chain-to-chain alignments, identified by efficiently clustering their superposition vectors. Foldseek-Multimer is 3-4 orders of magnitudes faster than the gold standard, while producing comparable alignments; allowing it to compare dozens of billions of complex-pairs in a day. Foldseek-Multimer is open-source software: <a href="http://github.com/steineggerlab/foldseek">github.com/steineggerlab/foldseek</a>&nbsp;and webserver:&nbsp;<a href="http://search.foldseek.com/">search.foldseek.com</a>.</p> <p><strong>Notice</strong><br>This Zenodo release accompanies the&nbsp;<a href="https://github.com/steineggerlab/foldseek-multimer-analysis/tree/main">GitHub repository</a>, which contains both the analysis scripts as well as clarifications about the data in this release.<br><br></p>