Dataset related to: "Relationship between perceived and neuromuscular fatigue in COPD patients with chronic respiratory failure with long‑term oxygen therapy: a cross‑sectional study"

<p>We provide the raw data used for the following article:</p> <p>Paneroni M, Vitacca M, Comini L, Salvi B, Saleri M, Schena F, Venturelli M. <strong>Relationship between perceived and neuromuscular fatigue in COPD patients with chronic respiratory failure with long-term oxygen therapy: a cross-sectional study</strong>. Eur J Appl Physiol. 2022 Nov;122(11):2403-2416. doi: 10.1007/s00421-022-05021-2.</p> <p>Abstract</p> <p><strong>Purpose:&nbsp;</strong>To evaluate perceived fatigue (PF) and neuromuscular fatigue (NMF) in patients with COPD and chronic respiratory failure (CRF) on long-term oxygen therapy (CRF-COPD group), and the relationships between PF, NMF, patient&#39;s characteristics, comparing severe patients with COPD to patients without CRF (COPD group).</p> <p><strong>Methods:&nbsp;</strong>This cross-sectional study compared 19 CRF-COPD patients with 10 COPD patients attending a rehabilitation program. PF was determined by Fatigue Severity Scale (FSS), while dyspnea by the Barthel Dyspnea Index (BDI). We assessed quadriceps NMF via electrical nerve stimulation during and following a Maximal Voluntary Contraction (MVC) detecting changes after a Constant Workload Cycling Test (CWCT) at 80% of the peak power output at exhaustion.</p> <p><strong>Results:&nbsp;</strong>CRF-COPD patients showed higher PF (+ 1.79 of FSS score, p = 0.0052) and dyspnea (+ 21.03 of BDI score, p = 0.0023) than COPD patients. After the fatiguing task and normalization for the total work, there was a similar decrease in the MVC (CRF-COPD -1.5 &plusmn; 2.4 vs COPD -1.1 &plusmn; 1.2% baseline kJ^-1, p = 0.5819), in the potentiated resting twitch force (CRF-COPD -2.8 &plusmn; 4.7 vs COPD -2.0 &plusmn; 3.3% baseline kJ^-1, p = 0.7481) and in the maximal voluntary activation (CRF-COPD -0.1 &plusmn; 3.9 vs COPD -0.9 &plusmn; 1.2 -2.0 &plusmn; 3.3% baseline kJ^-1, p = 0.4354). FSS and BDI were closely related (R = 0.5735, p = 0.0011), while no correlation between PF and NMF was found.</p> <p><strong>Conclusion:&nbsp;</strong>Patients with CRF-COPD develop higher levels of perceived fatigue and dyspnea than patients with COPD; while neuromuscular fatigue is similar, suggesting a mismatch between symptoms and neuromuscular dysfunction.</p> <p>&nbsp;</p>