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opencc-zeroJun 2023View details →

Data for: An AAV-CRISPR/Cas9-strategy for gene editing across divergent rodent species: Targeting neural oxytocin receptors as a proof of concept

A major issue in neuroscience is the poor translatability of research results from preclinical studies in animals to clinical outcomes. Comparative neuroscience can overcome this barrier by studying multiple species to differentiate between species-specific and general mechanisms of neural circuit functioning. Targeted manipulation of neural circuits often depends on genetic dissection, and use of this technique has been restricted to only a few model species, limiting its application in comparative research. However, ongoing advances in genomics make genetic dissection attainable in a growing number of species. To demonstrate the potential of comparative gene editing approaches, we developed a viral-mediated CRISPR/Cas9 strategy that is predicted to target the oxytocin receptor (Oxtr) gene in >80 rodent species. This strategy specifically reduced OXTR levels in all evaluated species (n=6), without causing gross neuronal toxicity. Thus, we show that CRISPR/Cas9-based tools can function in multiple species simultaneously. Thereby, we hope to encourage comparative gene editing and improve the translatability of neuroscientific research.

opencc-by-4.0Jul 2023View details →

Associated data underlying the publication "Flipped Classroom Real-World Activities for Learning Open Computing Concepts"

Various “open” concepts in Computing, such as open standards, open data, open licenses or system interoperability are becoming more important in the professional lives of software engineers. However, students usually do not receive a systematic education about these concepts ; rather they sporadically learn about a subset of these topics. This paper presents the revised version of the Open Computing course in the University of Zagreb, Faculty of Electrical Engineering and Computing (FER), which teaches a clear set of current topics focused on open data and correlating concepts. The new e-learning course is carried out using the “flipped classroom” educational method ; students construct their knowledge in a set of real-world mini-activities throughout the course, instead of passively learning from the official course resources. In this paper, we discuss our flipped classroom activities, their relation to revised Bloom’s taxonomy of educational objectives, and present the evaluation of the first course instance us- ing this model. Students’ feedback shows they welcome this change in approach, finding the course useful and interesting, and preferring this method to the traditional full lecture setting.

opencc-zeroJul 2023View details →

Data from: Dynamic balancing of risks and rewards in a large herbivore: Further extending predator-prey concepts to road ecology

Animal behavior is shaped by the ability to identify risks and profitably balance the levels of risks encountered with the payoffs experienced. Anthropogenic disturbances like roads generate novel risks and opportunities that wildlife must accurately perceive and respond to. Basic concepts in predator-prey ecology are often used to understand responses of animals to roads (e.g., increased vigilance, selection for cover in their vicinity). However, prey often display complex behaviors such as modulating space use given varying risks and rewards, and it is unclear if such dynamic balancing is used by animals in the context of road crossings. We tested whether animals dynamically balance risks and rewards relative to roads using extensive field -based and GPS collar data from elk in Yoho National Park (British Columbia, Canada) where a major highway completely bisects their range during most of the year. We analyzed elk behavior by combining hidden Markov movement models with a step-selection function framework. Rewards were indexed by a dynamic map of available forage biomass and risks were indexed by road crossings and traffic volumes. We found that elk generally selected intermediate and high forage biomass and avoided crossing the road. Most of the time, elk modulated their behavior given varying risks and rewards. When crossing the highway compared with not crossing, elk selected for greater forage biomass and this selection was stronger as the number of highway crossings increased. However, with traffic volume, elk only balanced foraging rewards when they crossed a single time during a travel sequence. Using a road ecology system, we empirically tested an important component of predator-prey ecology – the ability to dynamically modulate behavior in response to varying levels of risks and rewards. Such a test articulates how decision-making processes that consider the spatiotemporal variation in risks and rewards allow animals to successfully and profitably navigate busy roads. Applying well-developed concepts in predator-prey theory helps understand how animals respond to anthropogenic disturbances and anticipate the adaptive capacity for individuals and populations to adjust to rapidly changing environments.

opencc-zeroJun 2023View details →

FIG. 2 in Structural and functional genes, and highly repetitive sequences commonly used in the phylogeny and species concept of the phylum Cyanobacteria

FIG. 2. — Phylogeny of common or less studied genetic markers. According to the literature review,less common studied genetic marker has been highlighted.

opencc-zeroJun 2023View details →

FIG. 1. — A in Structural and functional genes, and highly repetitive sequences commonly used in the phylogeny and species concept of the phylum Cyanobacteria

FIG. 1. — A summary of structural and functional genes, and highly repetitive sequences commonly used in the phylogeny of cyanobacteria.

opencc-by-4.0Jul 2023View details →

GeoExposomics.org proof-of-concept catalogue as an Excel workbook

Part of the outputs of an International Society for Photogrammetry and Remote Sensing (ISPRS)-funded project entitled ‘geospatial database for exposomics (development of an online portal and metadata catalogue of Earth observation data types, sources and products for human health research in exposomics)’. The project is funded under ISPRS Scientific Initiatives 2023 (SI2023 Awards). P.I.: Prof. Maged N. Kamel Boulos. URL: https://geoexposomics.org/

opencc-by-4.0Jul 2023View details →

Towards substitution of invasive telemetry: An integrated home cage concept for unobtrusive monitoring of objective physiological parameters in rodents - Minimal dataset

Minimal dataset  for unobtrusive monitoring of vital parameters in rodents.

opencc-by-4.0Aug 2023View details →

Model output from "The chance of freezing – a conceptional study to parameterize temperature-dependent freezing by including randomness of ice-nucleating particle concentrations"

Model output from "The chance of freezing – a conceptional study to parameterize temperature-dependent freezing by including randomness of ice-nucleating particle concentrations", accepted for publication in Atmospheric Chemistry and Physics, 2023, same authors. The simulations were done using MIMICA version4 (Savre at el., 2014) and the data includes all model output presented in the publication.

opencc-by-4.0Aug 2023View details →

Lithium recovery from brines by lithium membrane flow capacitive deionization (Li-MFCDI) – A proof of concept

Dataset to H.M. Saif et al., <a href="https://www.sciencedirect.com/journal/journal-of-membrane-science-letters">Journal of Membrane Science Letters</a>, <a href="https://www.sciencedirect.com/journal/journal-of-membrane-science-letters/vol/3/issue/2">Volume 3, Issue 2</a>, November 2023, 100059 The demand of lithium for electric vehicles and energy storage devices is increasing rapidly, thus new sources of lithium (such as seawater and natural or industrial brines), as well as sustainable methods for its recovery, will need to be explored/developed soon. This work presents a novel electromembrane process, called Lithium Membrane Flow Capacitive Deionization (Li-MFCDI), which was tested to recover lithium from a synthetic geothermal brine containing a much higher mass concentration of sodium than lithium (more than 650 times). Specifically, a ceramic lithium-selective membrane was integrated into a flow capacitive deionization (FCDI) cell, which was specifically designed, and 3D printed, to allow simultaneous charging and regeneration of the employed flow electrodes. Despite the extremely high Na+/Li+ mass ratio in the feed stream, 99.98% of the sodium was rejected and the process selectivity for lithium over other monovalent cations was 141 ± 5.85 for Li+/Na+ and 46 ± 1.46 for Li+/K+. The Li-MFCDI process exhibited a stable behaviour over a 7-day test period, and the estimated energy consumption was 16.70 ± 1.63 kWh/kg of Li+ recovered in the draw solution. These results demonstrate promising potential of the Li-MFCDI for the sustainable lithium recovery from saline streams.

opencc-by-4.0Jul 2022View details →

Environmental Performance Assessment of a Novel Process Concept for Propanol Production from Widely Available and Wasted Methane Sources

Dataset for associated publication.

opencc-by-4.0Sep 2023View details →

Data from: Automatic patient-level recognition of four Plasmodium species on thin blood smear by a Real Time Detector Transformer (RT-DETR) object detection algorithm: a proof-of-concept and evaluation

Automatic patient-level recognition of four Plasmodium species on thin blood smear by a Real Time Dectector Transformer (RT-DETR) object detection algorithm: a proof-of-concept and evaluation Emilie Guemas, Baptiste Routier, Théo Ghelfenstein-Ferreira, Camille Cordier, Sophie Hartuis, Bénédicte Marion, Sébastien Bertout, Emmanuelle Varlet-Marie, Damien Costa, Grégoire Pasquier Abstract: Malaria remains a global health problem with 247 million cases and 619,000 deaths in 2021. Diagnostic of Plasmodium species is important for administering the appropriate treatment. The gold-standard diagnosis from accurate species identification remains the thin blood smear. Nevertheless, this method is time-consuming and requires highly skilled and trained microscopists. To overcome these issues, new diagnostic tools based on deep learning are emerging. This study aimed to evaluate the performances of a RT-DETR (Real-Time Detection Transformer)object detection algorithm to discriminate Plasmodium species on thin blood smears images. The algorithm was trained and validated on a dataset consisting in 24,720 images from 475 thin blood smears corresponding to 2,002,597 labels. Performances were calculated with a test dataset of 4,508 images from 170 smears corresponding to 358,825labels coming from six French university hospital. At the patient level, the RT-DETR algorithm exhibited an overall accuracy of 79.4% (135/170) with a recall of 74% (40/54) and 81.9% (95/116) for negative and positive smears, respectively. Among Plasmodium positive smears, the global sensitivity was 82.7% (91/110) with a sensitivity of 90% (38/42), 81.8% (18/22) and 76.1% (35/46) for P. falciparum, P. malariae and P. ovale/vivax, respectively. The YOLOv5 model achieved a World Health Organization (WHO) competence level 2 for species identification. Besides, the RT-DETR algorithm may be run in real-time on low-cost devices such as a smartphone and could be suitable for deployment in low-resource setting areas where microscopy experts are lacking. Data collection: The training and validation dataset included 24,720 pictures taken from 475 manually May Grunwald-Giemsa (MGG)-stained thin blood smears from the Montpellier University Hospital collection and for a smaller part from the Toulouse University Hospital collection. In Montpellier, the pictures were taken with a Flexcam C1 microscope camera (Leica) attached to a Leica DM 2000 microscope and Leica DF450C microscope camera adapted with a Leica DM2500 microscope at X1000 magnification. Labelling of pictures was performed manually, and then automatically with manual correction with a Computer Visual Annotation Tools (CVAT) free software. Nine categories of labels were used: white blood cells (n=3,338), red blood cells (n=1,887,781), platelets (n=48,520), Trypanosoma brucei (n=2,773), and red blood cells infected by P. falciparum (n=43,545), P. ovale (n=4,651), P. vivax (n=4,115), P. malariae (n=2,849) and Babesia divergens (n=5,142). The test dataset included 4,508 pictures taken from 170 thin blood smears from the same number of patients from the Parasitology laboratories of University Hospitals of Montpellier, Toulouse, Rouen, Lille, Nantes and Saint-Louis in Paris (Table 1). Among these 170 patients, 54 were not infected, including two patients with Howell-Jolly bodies, and 116 were infected with hematozoa. For each patient, between 20 and 30 photos were taken from one thin blood smear with at least one hematozoan parasite per picture for infected patients. Accurate species diagnostic was made by a senior parasitologist, and for recent smears, it was confirmed by specific PCR, either performed locally (Toulouse) or at the Malaria French National Reference Center (Montpellier, Saint Louis, Rouen, Lille, Nantes).

A Proof of Concept and Dose-finding Study of XXB750 in Patients With Heart Failure

ClinicalTrials.gov study NCT06142383. IPD Sharing: YES. Countries: 12. Publications: 0.

Proof of Concept Study Evaluating the Efficacy and Safety of MIJ821 in Patients With Treatment-resistant Depression

ClinicalTrials.gov study NCT03756129. IPD Sharing: YES. Countries: 2. Publications: 1.

closedIPD-NOFeb 2026View details →

Temporary Aortic Occlusion With the Abdominal Tourniquet for Refractory Postpartum Haemorrhage: A Proof-of-Concept Study in a War-Affected Region

ClinicalTrials.gov study NCT07016568. IPD Sharing: NO. Countries: 1. Publications: 7.

Proof-of-concept Study for SAR441344 (Frexalimab) in Relapsing Multiple Sclerosis

ClinicalTrials.gov study NCT04879628. IPD Sharing: YES. Countries: 10. Publications: 1.

Proof-of-Concept Study to Assess the Efficacy, Safety and Tolerability of SAR440340 (Anti-IL-33 mAb) in Patients With Moderate-to-severe Chronic Obstructive Pulmonary Disease (COPD)

ClinicalTrials.gov study NCT03546907. IPD Sharing: YES. Countries: 10. Publications: 1.

publicDec 2025View details →

Data from: When discrete characters are wanting: Continuous character integration under the phylospecies concept informs the revision of the Australian land snail Thersites (Eupulmonata, Camaenidae)

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publicJul 2025View details →

Computational simulations show proof-of-concept for optogenetic suppression of ectopic activity in cardiac stem cell therapy

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publicJun 2023View details →

Data for: An AAV-CRISPR/Cas9-strategy for gene editing across divergent rodent species: Targeting neural oxytocin receptors as a proof of concept

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