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4,004 results for “In vivo”
Recurrent Campylobacter jejuni infections with in vivo selection of resistance to macrolides and carbapenems – assembly dataset
<p><strong>Dataset</strong></p> <p>This dataset comprises the genome assemblies of the first isolate collected from each clinical case (A1 and B1), together with the respective annotation.</p> <p>File “Cje_metadata.xlsx” contains the genome assembly statistics for each isolate, including the European Nucleotide Archive (ENA) accession numbers, genotyping and antibiotic resistance profiles.</p> <p>The directory “Assemblies/” contains the genome assembly (.fasta and .gbk formats) of each isolate presented in the metadata file.</p> <p> </p> <p><strong>Genome assembly and annotation</strong></p> <p>Reads quality control and improvement, species confirmation (using the 8GB database available at https://ccb.jhu.edu/software/kraken/) and <em>de novo</em> assembly were performed using the INNUca v4.2.2 pipeline (https://github.com/B-UMMI/INNUca). Briefly, after reads’ quality analysis using FastQC v0.11.5 (http://www.bioinformatics.babraham.ac.uk/projects/fastqc/) and cleaning with Trimmomatic v0.38 (http://www.usadellab.org/cms/?page=trimmomatic), genomes were <em>de novo</em> assembled with SPAdes 3.14.0 (http://bioinf.spbau.ru/spades) with a mean depth of coverage above 160x, and subsequently improved using Pilon v1.23. Multi-Locus Sequence Typing (MLST) was performed using mlst v2.18.1 software (https://github.com/tseemann/mlst). Genome annotation was performed with RAST server v2.0 (http://rast.nmpdr.org/).</p> <p>The raw sequence reads of each isolate were deposited at ENA under the study accession numbers PRJEB42628 and PRJNA505131.</p> <p> </p> <p><strong>Funding</strong></p> <p>This work was supported by GenomePT (ref. POCI-01-0145-FEDER-022184) from Fundação para a Ciência e Tecnologia, Portugal.</p>
Leishmanicidal and healing effects of 3β,6β,16β-trihydroxy lup-20 (29)-ene isolated from Combretum leprosum on Leishmania braziliensis infection in vitro and in vivo
<p>Treatment of cutaneous leishmaniasis depends on drugs that potentially cause serious side effects and resistance. Thus, topical therapies are attractive alternatives to the drugs currently used. 3β, 6β, 16β-trihydroxylup-20 (29)-ene is a lupane triterpene isolated from Combretum leprosum Mart. leaves (CLF-1), with reports of in vitro antileishmanial effect against L. amazonensis and to promote lesion healing in animal model. Herein, we evaluated the in vitro and in vivo antileishmanial and healing effects of CLF-1 against L. braziliensis. CLF-1 treatment showed low toxicity in macrophages and significantly reduced parasite load in vitro. CLF-1 induced higher IL-12 and TNF-α production and more discrete IL-4 and IL-10 production. For in vivo evaluation, a CLF-1 cream formulation was prepared to treat hamsters infected with L. braziliensis. CLF-1 treatment was able to reduce parasite load on the infected skin and lymph node more efficiently than the conventional treatment. Histopathological analysis indicated a strong inflammatory response accompanied by an important healing response. Data from this study indicate that topical CLF-1 treatment was effective and non-toxic in L. braziliensis infected hamsters suggesting its potential for further development as a future therapeutic intervention.</p>
FB28-stained intracellular structures in butterfly wing epithelial cells in vivo
<p>We reconstructed the 3D video images of FB28-stained intracellular structures in butterfly wing epithelial cells in vivo. These videos are supplementary materials for Figure 5a and Figure 5b in a research article.</p>
Data for the publication: "Development and In-Vivo Validation of a Portable Phosphorescence Lifetime-Based Fiber-Optic Oxygen Sensor"
<p>This data set contains all raw data for the publication “Development and In-Vivo Validation of a Portable Phosphorescence Lifetime-Based Fiber-Optic Oxygen Sensor”:</p> <p>- Raw sensor data</p> <p>- Python scripts</p> <p>- particle photon scripts</p> <p>- CAD Drawings</p> <p>- PCB Designs</p>
In vivo noninvasive systemic myography of acute systemic vasoactivity in female pregnant mice
<p>Altered vasoactivity is a major characteristic of cardiovascular and oncological diseases, and many therapies are therefore targeted to the vasculature. Therapeutics which are selective for the diseased vasculature are ideal, but whole-body selectivity of a therapeutic is challenging to assess in practice. Vessel myography is used to determine the functional mechanisms and evaluate pharmacological responses of vascularly-targeted therapeutics. However, myography can only be performed on ex vivo sections of individual arteries. We have developed methods for implementation of spherical-view photoacoustic tomography for non-invasive and in vivo myography. Using photoacoustic tomography, we demonstrate the measurement of acute vascular reactivity in the systemic vasculature and the placenta of pregnant mice in response to two vasodilators. Photoacoustic tomography simultaneously captured the significant acute vasodilation of major arteries and detected the selective vasoactivity of the maternal-fetal vasculature. Photoacoustic tomography has the potential to provide invaluable preclinical information on vascular response that cannot be obtained by other established methods.</p>
DATA SET: In vivo characterization of the optical and hemodynamic properties of the human sternocleidomastoid muscle through ultrasound-guided hybrid near-infrared spectroscopies.
<p>This repository contains the data sets of the article:</p><p>L. Cortese et al., "In vivo characterization of the optical and hemodynamic properties of the human sternocleidomastoid muscle through ultrasound-guided hybrid near-infrared spectroscopies."</p>
Differential Short-Term Facilitation Of Synaptic Inputs And Spike Transmission At The Retinocollicular Synapse In Vivo
<p>Neuropixels data for investigating short-term plasticity in the mouse retinocollicular pathway. </p> <p>Paper (bioRxiv): <a href="https://www.biorxiv.org/content/10.1101/2024.01.17.576068v1">Differential Short-Term Facilitation Of Synaptic Inputs And Spike Transmission At The Retinocollicular Synapse In Vivo</a></p> <p>Full data will be availale upon publication of the paper.</p>
Investigation and Modulation of the Mu-Opioid Mechanisms in Migraine (in Vivo)
ClinicalTrials.gov study NCT02964741. IPD Sharing: NO. Countries: 1. Publications: 2.
Radiographic Progression of Infiltrated Caries Lesions In-vivo
ClinicalTrials.gov study NCT01496456. IPD Sharing: NO. Countries: 1. Publications: 1.
In Vivo Evaluation of the Accuracy of Immediate Screw-Retained Provisional Crowns Fabricated Using Digital Planning and Guided Surgery
ClinicalTrials.gov study NCT07315607. IPD Sharing: NO. Countries: 1. Publications: 19.
Long-term Follow-up of Subjects With Transfusion-Dependent β-Thalassemia (TDT) Treated With Ex Vivo Gene Therapy
ClinicalTrials.gov study NCT02633943. IPD Sharing: YES. Countries: 8. Publications: 3.
Transplantation of NiCord®, Umbilical Cord Blood-derived Ex Vivo Expanded Cells, in Patients With HM
ClinicalTrials.gov study NCT01816230. IPD Sharing: Not stated. Countries: 5. Publications: 1.
A Prospective Study of Remestemcel-L, Ex-vivo Cultured Adult Human Mesenchymal Stromal Cells, for the Treatment of Pediatric Participants Who Have Failed to Respond to Steroid Treatment for Acute Graf
ClinicalTrials.gov study NCT02336230. IPD Sharing: NO. Countries: 1. Publications: 1.
Novel in Vivo Synaptic Imaging in Experienced Meditators
ClinicalTrials.gov study NCT05418608. IPD Sharing: YES. Countries: 1. Publications: 22.
VO2 Max: In Vivo Model for Functional Red Cell Testing. Can RECESS be Explained?
ClinicalTrials.gov study NCT02918851. IPD Sharing: NO. Countries: 1. Publications: 1.
In Vivo Comparison of Salivary Fluoride Levels Following the Application of Different 5% NaF Varnishes
ClinicalTrials.gov study NCT01629290. IPD Sharing: NO. Countries: 1. Publications: 1.
In Vivo Arthroscopic Behavior of the Infrapatellar Plica of the Knee
ClinicalTrials.gov study NCT00643487. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Peer Social Support During In Vivo Exposure for PTSD
ClinicalTrials.gov study NCT03485391. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Biosynthesis of PGD2 in Vivo
ClinicalTrials.gov study NCT01275300. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Allogeneic SCT of NiCord®, UCB-Derived Ex Vivo Expanded Stem and Progenitor Cells, in Patients With Hemoglobinopathies
ClinicalTrials.gov study NCT01590628. IPD Sharing: Not stated. Countries: 1. Publications: 1.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.