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185 results for “animal experimentation”
Data from: Revisiting Brownian motion as a description of animal movement: a comparison to experimental movement data
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Data from: Increased survival of experimentally evolved antimicrobial peptide-resistant Staphylococcus aureus in an animal host
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Data from: Assortative mating among animals of captive and wild origin following experimental conservation releases
Captive breeding is a high profile management tool used for conserving threatened species. However, the inevitable consequence of generations in captivity is broad scale and often-rapid phenotypic divergence between captive and wild individuals, through environmental differences and genetic processes. Although poorly understood, mate choice preference is one of the changes that may occur in captivity that could have important implications for the reintroduction success of captive-bred animals. We bred wild-caught house mice for three generations to examine mating patterns and reproductive outcomes when these animals were simultaneously released into multiple outdoor enclosures with wild conspecifics. At release, there were significant differences in phenotypic (e.g. body mass) and genetic measures (e.g. Gst and F) between captive-bred and wild adult mice. Furthermore, 83% of offspring produced post-release were of same source parentage, inferring pronounced assortative mating. Our findings suggest that captive breeding may affect mating preferences, with potentially adverse implications for the success of threatened species reintroduction programmes.
Data from: Assortative mating among animals of captive and wild origin following experimental conservation releases
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3R information retrieval self-reports by aspiring directors of animal experimentation
<p>This dataset (qualitative data) consists in 215 anonymized pdfs of 3R information retrieval self-reports completed by aspiring directors of animal experimentation before 5 educational sessions on information retrieval (2012 to 2015). Visible confidential data, name, address, institution or industry, lab name, email, phone numbers were suppressed with Adobe Pro XI Redaction tool, as well hidden data, such as metadata with sanitization tool.</p> <p>In 2012, 2013, 2014, 2015, aspiring directors of animal experimentation were assigned a 3R information retrieval homework prior attending a mandatory 3 hours face-to-face information retrieval seminar. Participants had to send back self-reports to course organizer of the training module (Module-2), the one week mandatory course for aspiring directors of animal experimentation located in Switzerland. In 2015, before performing self-report, aspiring directors made an online test about basics of information retrieval, 3Rs, and open access. They should obtain 60% of right answers and forwarded the automatic generated certificate to course organizer. Researchers could answer the questions with their personal knowledge or find them in commented presentations and screen castings available on 3Rupdate.ch plateform.</p> <p>Homework were not designed originally to analyze information retrieval skills. The original goal for the homework was to draw more attention and retention from the researchers during the 3 hours seminar. It was thought that if researchers faced difficulties in searching 3R information, it would generate additional motivation for the course. Therefore, self-reports were not marked; no direct individual feed-back was given to the participants, but the face-to-face session was a kind of homework correction, a way to give tips about 3R information retrieval in order to improve their searches. The second goal was to allow researchers to think about how they selected and handled search tools, instead of relying on closely related peers and personal knowledge to gather information on the research subject, an approach that is well known and natural: with time, researchers rely much more on their own network of peers rather than on online information resources to follow the latest development in their field.</p> <p>The homework topic was related to study model selection. The choice of a study model is crucial from a 3R point of view, but also for later scientific result validity: it is not an easy task for fundamental researchers to follow new animal models available on market. Neither is the one to follow new in vitro alternatives, such as 3D tissue cultures, stem cells, and <em>in vitro</em> screening techniques for fundamental researchers using animal experimentation.</p> <p>The case study was: Which mice, or non-vertebrate, or in vitro models are used to study Huntington disease?</p> <p>Homework structure consisted of a brief theory on 3R information retrieval, suggested search tools to be used, and 3 assignments. The first assignment was to perform a search on the subject, the second one to report best searches, namely keywords and search strings used in two selected tools with corresponding relevant references and generated bibliography. The third assignment invited researchers to comment freely about their tool choices, tool differences, and report self-criticism on search strategy, submitting better formulation of the initial query for a better information retrieval process. </p> <p> </p>
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.