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769 results for “deprivation”
Figure 4 from: Vyshedskiy A, Mahapatra S, Dunn R (2017) Linguistically deprived children: meta-analysis of published research underlines the importance of early syntactic language use for normal brain development. Research Ideas and Outcomes 3: e20696. https://doi.org/10.3897/rio.3.e20696
Figure 4 - Synchronicity has to be understood in terms of synchronicity of the arrival of action potentials to a target neuron rather than absolute equality of action potential conduction times over different paths. Consider the following example: suppose neuron A is receiving excitatory input from neurons B and C via two different pathways (neuron A is the target neuron for both neurons B and C). Suppose that the action potential conduction time is 2ms from neuron B to neuron A and 22ms from neuron C to neuron A (i.e., the axonal pathway B-A has a significantly shorter conduction time than the axonal pathway C-A). Does it mean that the connections B-A and C-A are always asynchronous? No. The answer depends on the predominant neural activity rhythm in this network. At the firing rate of 50Hz (inter-spike interval of 20ms that correspond to Gamma rhythm), neurons B and C can actually be considered synchronous in relationship to neuron A: consider a train of action potentials synchronously fired by neurons B and C. The first action potential from neuron B will reach neuron A in 2ms and the first action potential from neuron C will reach neuron A in 22ms. Obviously, there would be no coincidence in the arrival times of the 1st action potentials from neurons B and C. However the second action potential from neuron B will arrive to neuron A in 22ms, concurrently with the 1st action potential from neuron C. Thus, starting with the second action potential, neuron A will receive synchronous activation from neurons B and C. The synchronous activation has a significantly greater probability of enhancing synaptic connections between neurons A and B, and A and C (Hebbian learning: 'neurons that fire together, wire together' (Hebb 1949). Thus, synchronicity does not need to imply absolute equality in the conduction time over different pathways. Rather synchronicity implies near-zero phase-shift between the two firing trains of action potentials at the postsynaptic cells. This phase-shift depends on conduction times over each pathway and also on the dominant firing frequency in the neural network.
Figure 2 from: Vyshedskiy A, Mahapatra S, Dunn R (2017) Linguistically deprived children: meta-analysis of published research underlines the importance of early syntactic language use for normal brain development. Research Ideas and Outcomes 3: e20696. https://doi.org/10.3897/rio.3.e20696
Figure 2 - A typical question testing subject's ability to mentally rotate an object is shown here as a 2x2 matrix with six answer choices displayed below the problem. The top row of the matrix indicates the rule: "the object in the right column is the result of 45° clockwise rotation." Applying this rule to the bottom row, we arrive at the correct answer depicted on the right.
Figure 1 from: Vyshedskiy A, Mahapatra S, Dunn R (2017) Linguistically deprived children: meta-analysis of published research underlines the importance of early syntactic language use for normal brain development. Research Ideas and Outcomes 3: e20696. https://doi.org/10.3897/rio.3.e20696
Figure 1 - Visual information processing in the cortex. From the primary visual cortex (V1, shown in yellow), the visual information is passed in two streams. The neurons along the ventral stream also known as the ventral visual cortex (shown in purple) are primarily concerned with what the object is. The ventral visual stream runs into the inferior temporal lobe. The neurons along the dorsal stream also known the dorsal visual cortex (shown in green) are primarily concerned with where the object is. The dorsal visual stream runs into the parietal lobe.
Figure 3 from: Vyshedskiy A, Mahapatra S, Dunn R (2017) Linguistically deprived children: meta-analysis of published research underlines the importance of early syntactic language use for normal brain development. Research Ideas and Outcomes 3: e20696. https://doi.org/10.3897/rio.3.e20696
Figure 3 - Linguistic isolates performance in verbal and nonverbal tests. This Figure is also available as a Power Point slide in Suppl. material 1.
Association of neighborhood-level material deprivation with healthcare costs and outcome after stroke
<p>The objective was to determine the association between material deprivation and direct healthcare costs and clinical outcomes following stroke in the context of a publicly funded universal healthcare system. In this population-based cohort study of patients with ischemic and hemorrhagic stroke admitted to hospital between 2008 and 2017 in Ontario, Canada, we used linked administrative data to identify the cohort, predictor variables, and outcomes. The exposure was a five-level neighborhood material deprivation index. The primary outcome was direct healthcare costs incurred by the public payer in the first year. Secondary outcomes were death and admission to long-term care. Among 90,289 patients with stroke, the mean (standard deviation) per-person costs increased with increasing material deprivation, from $50,602 ($55,582) in the least deprived quintile to $56,292 ($59,721) in the most deprived quintile (unadjusted relative cost ratio and 95% confidence intervals 1.11 [1.08,1.13] and adjusted relative cost ratio 1.07 [1.05,1.10] for least compared to most deprived quintile). People in the most deprived quintile had higher mortality within one year compared to the least deprived quintile (adjusted hazard ratio (HR) 1.07 [1.03,1.12]) as well as within three years (adjusted HR 1.09 [1.05,1.13]). Admission to long-term care increased incrementally with material deprivation and those in the most deprived quintile had an adjusted HR of 1.33 [1.24,1.43]) compared to those in the least deprived quintile. Material deprivation is a risk factor for increased costs and poor outcomes after stroke. Interventions targeting health inequities due to social determinants of health are needed.</p>
An Efficacy and Safety Study of Enzalutamide Plus Androgen Deprivation Therapy (ADT) Versus Placebo Plus ADT in Chinese Patients With Metastatic Hormone Sensitive Prostate Cancer (mHSPC)
ClinicalTrials.gov study NCT04076059. IPD Sharing: YES. Countries: 1. Publications: 0.
Androgen Deprivation Therapy and Vorinostat Followed by Radical Prostatectomy in Treating Patients With Localized Prostate Cancer
ClinicalTrials.gov study NCT00589472. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Dose Escalation and Dose Expansion Study of GSK525762 in Combination With Androgen Deprivation Therapy in Participants With Castrate-resistant Prostate Cancer
ClinicalTrials.gov study NCT03150056. IPD Sharing: YES. Countries: 4. Publications: 0.
A Study of Androgen Deprivation With Leuprolide, +/- Docetaxel for Clinically Asymptomatic Prostate Cancer Participants With a Rising Prostate Specific Antigen (PSA)
ClinicalTrials.gov study NCT00514917. IPD Sharing: Not stated. Countries: 9. Publications: 0.
Effects of Sleep Deprivation on Food Intake and Motor Activity in Man
ClinicalTrials.gov study NCT00986492. IPD Sharing: Not stated. Countries: 0. Publications: 1.
The Effects of Acute Caloric Deprivation on Odour Identification and Food Reward
ClinicalTrials.gov study NCT02653378. IPD Sharing: NO. Countries: 0. Publications: 2.
Soy Derivatives for Control of Hot Flashes in Men on Androgen Deprivation Therapy
ClinicalTrials.gov study NCT00594620. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Pilot Study on Community Gardens and Food Purchases in Deprived Neighborhood (Marseille, France)
ClinicalTrials.gov study NCT03175575. IPD Sharing: NO. Countries: 0. Publications: 1.
Comparison of Duration of Treatment Interruption With or Without Curcumin During the Off Treatment Periods in Patients With Prostate Cancer Undergoing Intermittent Androgen Deprivation Therapy
ClinicalTrials.gov study NCT03211104. IPD Sharing: Not stated. Countries: 0. Publications: 2.
Transdermal Estradiol and Exercise in Mitigating Adverse Effects of Androgen Deprivation Therapy for Prostate Cancer Radiation Therapy
ClinicalTrials.gov study NCT06271551. IPD Sharing: NO. Countries: 0. Publications: 1.
Modulation of CSF Amyloid-beta Concentrations Via Behavioral Sleep Deprivation and Pharmacological Sleep Induction
ClinicalTrials.gov study NCT02063217. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Androgen-Deprivation Therapy and Radiation Therapy in Treating Patients With Prostate Cancer
ClinicalTrials.gov study NCT01368588. IPD Sharing: NO. Countries: 6. Publications: 0.
Effects of Sleep Deprivation and Recovery on Cognitive Functions
ClinicalTrials.gov study NCT00179322. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Mobile Health App to Mitigate the Metabolic Effects of Androgen Deprivation Therapy
ClinicalTrials.gov study NCT03761160. IPD Sharing: YES. Countries: 1. Publications: 0.
Prostate Cancer Study In Men Who Have Failed First-Line Androgen Deprivation Therapy
ClinicalTrials.gov study NCT00470834. IPD Sharing: YES. Countries: 2. Publications: 0.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.