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183 results for “exercise stress”
very moderate exercise training; variations in stress and toxicity gene expression in rat hearts.
GEO Series GSE3904. Mus musculus; Rattus norvegicus. 6 samples. Type: Expression profiling by array.
Dataset from: "Prognostic Value of Dynamic Changes in Pulmonary Congestion During Exercise Stress Echocardiography in Heart Failure With Preserved Ejection Fraction"
<p>BACKGROUND: Patients with heart failure (HF) with preserved ejection fraction (HFpEF) typically develop dyspnea and<br> pulmonary congestion upon exercise. Lung ultrasound is a simple diagnostic tool, providing semiquantitative assessment<br> of extravascular lung water through B-lines. It has been shown that patients with HFpEF develop B-lines upon submaximal<br> exercise stress echocardiography; however, whether exercise-induced pulmonary congestion carries prognostic implications<br> is unknown. This study aimed at evaluating the prognostic value of B-line assessment during exercise in patients with HFpEF.<br> METHODS: Sixty-one New York Heart Association class I to II patients with HFpEF underwent standard echocardiography,<br> lung ultrasound (28-scanning point method), and BNP (B-type natriuretic peptide) assessment during supine exercise<br> echocardiography (baseline and peak exercise). The primary end point was a composite of cardiovascular death or HF<br> hospitalization at 1 year.<br> RESULTS: B-lines, E/e′, and BNP significantly increased during exercise (P<0.001 for all). By multivariable analysis, both peak<br> (hazard ratio, 1.50 [95% CI, 1.21–1.85], P<0.001), and change (hazard ratio 1.34 [95% CI, 1.12–1.62], P=0.002) B-lines<br> were retained as independent predictors of outcome (hazard ratios per 1 B-line increment), along with BNP and E/e′ ratio.<br> Importantly, adding peak B-line on top of a clinical model significantly improved prognostic accuracy (C-index increase, 0.157<br> [0.056–0.258], P=0.002) and net reclassification (continuous net reclassification improvement, 0.51 [0.09–0.74], P=0.016),<br> with similar results for B-line change.<br> CONCLUSIONS: Detection of exercise-induced pulmonary congestion by lung ultrasound is an independent predictor of outcome<br> in patients with HFpEF; its use may help refining the routine risk stratification of these patients on top of well-established<br> clinical variables.</p>
Does chest shape influence exercise stress echocardiographic results in patients with suspected coronary artery disease?
<p>Raw data related to the article</p> <p>Abstract<br> Despite the good specificity of exercise stress echocardiography (ESE) for the detection of coronary artery disease (CAD),<br> false positive (FP) results may occur. We have previously reported that chest abnormalities may affect parameters of cardiac<br> contractility. The influence of chest shape on ESE results has never been previously investigated. We retrospectively analyzed<br> 160 consecutive patients (64.4 ± 13.0-year old, 91 women) who had undergone coronary angiography at our Institution<br> because of positive ESE, between June 2014 and May 2020. Modified Haller index (MHI; chest transverse diameter over<br> the distance between sternum and spine) was assessed in all patients. Obstructive CAD was diagnosed by ≥ 70% stenosis<br> in any epicardial coronary artery. Outcome was false-positivity at ESE. 80.6% of patients were diagnosed with obstructive<br> CAD, while 19.4% had no CAD (FP). We separately analyzed patients with normal chest shape (MHI ≤ 2.5) and those with<br> concave-shaped chest wall (MHI > 2.5). These latter were mostly women with small cardiac chambers, mitral valve prolapse<br> (MVP) and exercise-induced ST-segment changes. Likelihood of false-positivity was significantly higher in subjects with<br> MHI > 2.5 than those with MHI ≤ 2.5 (30.7% vs 9.4%, p = 0.001). By multivariate logistic regression analysis, MHI > 2.5<br> (OR 4.04, 95%CI 1.45–11.2, p = 0.007), MVP (OR 3.47, 95%CI 1.32–9–12, p = 0.01) and dyssynergy in the left circumflex<br> territory (OR = 3.35, 95%CI 1.26–8.93, p = 0.01) were independently associated with false-positivity. Concave-shaped chest<br> wall (MHI > 2.5) may be associated with false-positive stress echocardiographic result. Mechanisms underpinning this finding<br> need to be further explored.</p>
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OpenNeuro
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