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187
datasets available to search
ShareScore release 0.7.1
Dataset results
187 results for “genetic correlations”
Molecular-genetic correlates of fatigue in cancer patients receiving localized external beam radiation therapy
GEO Series GSE30174. Homo sapiens. 80 samples. Type: Expression profiling by array.
Human-correlated genetic HCC and HCC-organoid models identify combination therapy for precision medicine
GEO Series GSE275444. Mus musculus. 216 samples. Type: Expression profiling by high throughput sequencing.
Correlation Between the Genetic and Neuroimaging Signatures in Newly Diagnosed Glioblastoma Patients Before Surgery
ClinicalTrials.gov study NCT02590497. IPD Sharing: Not stated. Countries: 0. Publications: 0.
The Correlation Between Genetic Polymorphism, Platelet Activity, Clopidogrel Responsiveness, and Serum Adipokine Concentration in Asian Acute Coronary Syndrome Patients
ClinicalTrials.gov study NCT01255267. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Genetic correlates in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia treated with Hyper-CVAD plus dasatinib or ponatinib
GEO Series GSE190395. Homo sapiens. 95 samples. Type: Genome variation profiling by high throughput sequencing.
Genetic, clinical, and biomarker correlates of EGFR inhibitor-related rash
GEO Series GSE115468. Homo sapiens. 50 samples. Type: Expression profiling by array.
Genomic evidence for correlated trait combinations and antagonistic selection contributing to counterintuitive genetic patterns of adaptive diapause divergence in Rhagoletis flies
<p>Adaptation to novel environments often results in unanticipated genomic responses to selection. Here, we illustrate how multifarious, correlational selection helps explain a counterintuitive pattern of genetic divergence between the recently derived apple- and ancestral hawthorn-infesting host races of <i>Rhagoletis pomonella</i> (Diptera: Tephritidae). The Apple host race terminate diapause and emerge as adults earlier in the season than the hawthorn host race to coincide with the earlier fruiting phenology of their apple hosts. However, alleles at many loci associated with later emergence paradoxically occur at higher frequencies in sympatric populations of the apple than hawthorn race. We present genomic evidence that historical selection over geographically varying environmental gradients across North America generated genetic correlations between two life history traits, diapause intensity and diapause termination, in the hawthorn host race that are strongly associated with genomic regions in high linkage disequilibrium (LD). These genetic correlations are antagonistic to contemporary selection on local apple host race populations for increased initial diapause depth coupled with earlier, not later, diapause termination. Thus, the paradox of apple flies appears due, in part, to pleiotropy or linkage of alleles associated with later adult emergence with increased initial diapause intensity, the latter trait strongly selected for by the earlier phenology of apples. In contrast, loci associated only with diapause termination and not also initial diapause intensity showed the expected pattern (more early-associated alleles in the apple race) in half of sympatric population pairs surveyed. Our results demonstrate how a more complete understanding of multivariate trait combinations and the correlative nature of selective forces acting on them may generally help improve predictions of the genomics of rapid adaptive evolution and explain seemingly counterintuitive patterns of genetic diversity in nature.</p>
ScienceDex guides
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.