Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
213
datasets available to search
ShareScore release 0.9.0
Dataset results
213 results for “in vitro cultures”
Effects of targeting MTDH-SND1 interaction in mammary tumor cell and normal mammary epithelial cell in 3D culture in vitro
GEO Series GSE174622. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Transcriptional profiling of in vitro cultured mouse hepatocytes and hepatocyte-derived biliary cells
GEO Series GSE159885. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
NAD+-dependent Sirt6 is a key regulator involved in telomere shortening of in vitro-cultured preimplantation embryos
GEO Series GSE280684. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
NAD+-dependent Sirt6 is a key regulator involved in telomere shortening of in vitro-cultured preimplantation embryos [Bisulfite-Seq]
GEO Series GSE299048. Mus musculus. 12 samples. Type: Methylation profiling by high throughput sequencing.
Single-cell RNA-sequencing overviews global inflammatory response in in vitro organ cultured testes
GEO Series GSE189805. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Comparison of the DNA methylation of in vitro cultured bovine SAM-treated blastocysts and non-treated blastocysts
GEO Series GSE74081. Bos taurus. 12 samples. Type: Methylation profiling by genome tiling array.
Effect of MIDKINE on in vitro culture of FLT3LG-bone marrow derived dendritic cells
GEO Series GSE227287. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Transcriptional programs of in vitro-expanded HSPCs with acute disruption of Lmo2 before and after co-culture with OP9-DLL1
GEO Series GSE287751. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
RNA-seq of tobacco explants cultured by different NAA concentrations during in vitro tissue culture
GEO Series GSE280743. Nicotiana tabacum. 6 samples. Type: Expression profiling by high throughput sequencing.
Dataset related to article "An in vitro model for osteoarthritis using long-cultured inflammatory human macrophages repeatedly stimulated with TLR agonists"
<p>This record contains new data related to article "An in vitro model for osteoarthritis using long-cultured inflammatory human macrophages repeatedly stimulated with TLR agonists".</p> <p>Osteoarthritis (OA) is characterized by an abundance of inflammatory M1-like macrophages damaging local tissues. The search of new potential drugs for OA suffers from the lack of appropriate methods of long-lasting inflammation. Here we developed and characterized an <em>in vitro</em> protocol of long-lasting culture of primary human monocyte-derived macrophages differentiated with a combination of M-CSF+GM-CSF that optimally supported long-cultured macrophages (LC-Mfs) for up to 15 days, unlike their single use. Macrophages repeatedly stimulated for 15 days with the TLR2 ligand Pam3CSK4 (LCS-Mfs), showed sustained levels over time of IL-6, CCL2 and CXCL8, inflammatory mediators that were also detected in the synovial fluids of OA patients. Furthermore, macrophages isolated from the synovia of two OA patients showed an expression profile of inflammation-related genes similar to that of LCS-Mfs, validating our protocol as a model of chronically activated inflammatory macrophages. Next, to confirm that these LCS-Mfs could be modulated by anti-inflammatory compounds, we employed Dexamethasone and/or Celecoxib, two drugs widely used in OA treatment, that significantly inhibited the production of inflammatory mediators. This easy-to-use in vitro protocol of long-lasting inflammation with primary human macrophages could be useful for the screening of new compounds to improve the therapy of inflammatory disorders.</p>
Dataset related to article "An in vitro model for osteoarthritis using long-cultured inflammatory human macrophages repeatedly stimulated with TLR agonists"
<p>This record contains new data related to article "An in vitro model for osteoarthritis using long-cultured inflammatory human macrophages repeatedly stimulated with TLR agonists".</p> <p>Osteoarthritis (OA) is characterized by an abundance of inflammatory M1-like macrophages damaging local tissues. The search of new potential drugs for OA suffers from the lack of appropriate methods of long-lasting inflammation. Here we developed and characterized an <em>in vitro</em> protocol of long-lasting culture of primary human monocyte-derived macrophages differentiated with a combination of M-CSF+GM-CSF that optimally supported long-cultured macrophages (LC-Mfs) for up to 15 days, unlike their single use. Macrophages repeatedly stimulated for 15 days with the TLR2 ligand Pam3CSK4 (LCS-Mfs), showed sustained levels over time of IL-6, CCL2 and CXCL8, inflammatory mediators that were also detected in the synovial fluids of OA patients. Furthermore, macrophages isolated from the synovia of two OA patients showed an expression profile of inflammation-related genes similar to that of LCS-Mfs, validating our protocol as a model of chronically activated inflammatory macrophages. Next, to confirm that these LCS-Mfs could be modulated by anti-inflammatory compounds, we employed Dexamethasone and/or Celecoxib, two drugs widely used in OA treatment, that significantly inhibited the production of inflammatory mediators. This easy-to-use in vitro protocol of long-lasting inflammation with primary human macrophages could be useful for the screening of new compounds to improve the therapy of inflammatory disorders.</p>
Effects of Th17 cytokines on transcriptome of primary microglial cultures in vitro
GEO Series GSE221715. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Cell-type specific gene expression profiling in heterogeneous in vitro cultures using epitope-tagged RPL22
GEO Series GSE149076. Homo sapiens; Mus musculus. 7 samples. Type: Expression profiling by high throughput sequencing.
Comparison of gene expression profiles of ex vivo sorted Common Lymphoid Progenitors (CLPs) and in vitro cultured cCLPs.
GEO Series GSE109805. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Characterization of in vitro cultured alveolar macrophages (AM) transcriptomes following DON treatment
GEO Series GSE210076. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Comparison of the transcription (coding and lncRNAs) of in vitro cultured bovine SAM-treated blastocysts and non-treated blastocysts
GEO Series GSE75430. Bos taurus. 8 samples. Type: Expression profiling by array.
In Vitro Culture of the Insect Endosymbiont Spiroplasma poulsonii Highlights Bacterial Genes Involved in Host-Symbiont Interaction
GEO Series GSE112290. Spiroplasma poulsonii. 6 samples. Type: Expression profiling by high throughput sequencing.
Effect of in vitro embryo culture and embryo transfer on global expression profiling of the fetal lung tissue in mice
GEO Series GSE101054. Mus musculus. 27 samples. Type: Expression profiling by array.
Effect of MIDKINE on in vitro culture of FLT3LG-bone marrow cells
GEO Series GSE227286. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Gene expression profile in human ovarian granulosa cells during long-term in vitro culture
GEO Series GSE129919. Homo sapiens. 8 samples. Type: Expression profiling by array.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.