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233
datasets available to search
ShareScore release 0.9.0
Dataset results
233 results for “sex determination”
An ancient protein-DNA interaction underlying metazoan sex determination
GEO Series GSE64892. Homo sapiens; Mus musculus. 7 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Transcriptomic responses to environmental temperature by turtles with thermosensitive and genotypic sex determination assessed by RNAseq inform the genetic architecture of embryonic gonadal developmen
GEO Series GSE94871. Chrysemys picta; Apalone spinifera. 20 samples. Type: Expression profiling by high throughput sequencing.
The master male sex determinant Gdf6Y of the turquoise killifish arose through allelic neofunctionalization [Mouse]
GEO Series GSE233995. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
Sex-determining 3D regulatory hubs revealed by genome spatial auto-correlation analysis [RNA-seq]
GEO Series GSE217617. Mus musculus. 26 samples. Type: Expression profiling by high throughput sequencing.
A Y-linked duplication of anti-Mullerian hormone is the sex determination gene in threespine stickleback
GEO Series GSE296766. Gasterosteus aculeatus. 36 samples. Type: Expression profiling by high throughput sequencing.
Environmentally Induced Epigenetic Transgenerational Inheritance of Altered SRY Genomic Binding During Gonadal Sex Determination
GEO Series GSE72469. Rattus norvegicus. 3 samples. Type: Genome binding/occupancy profiling by genome tiling array.
A novel evolutionary conserved mechanism of RNA stability regulates synexpression of primordial germ cell-specific genes prior to the sex-determination stage
GEO Series GSE104726. Oryzias latipes. 8 samples. Type: Expression profiling by array.
Data from: The fate of W chromosomes in hybrids between wild silkmoths, Samia cynthia ssp.: no role in sex determination and reproduction
Moths and butterflies (Lepidoptera) have sex chromosome systems with female heterogamety (WZ/ZZ or derived variants). The maternally inherited W chromosome is known to determine female sex in the silkworm, Bombyx mori. However, little is known about the role of W chromosome in other lepidopteran species. Here we describe two forms of the W chromosome, W and neo-W, that are transmitted to both sexes in offspring of hybrids from reciprocal crosses between subspecies of wild silkmoths, Samia cynthia. We performed crosses between S. c. pryeri (2n=28, WZ/ZZ) and S. c. walkeri (2n=26, neo-Wneo-Z/neo-Zneo-Z) and examined fitness and sex chromosome constitution in their hybrids. The F1 hybrids of both reciprocal crosses had reduced fertility. Fluorescence in situ hybridization revealed not only the expected sex chromosome constitutions in the backcross and F2 hybrids of both sexes but also females without the W (or neo-W) chromosome and males carrying the W (or neo-W) chromosome. Furthermore, crosses between the F2 hybrids revealed no association between the presence or absence of W (or neo-W) chromosome and variations in the hatchability of their eggs. Our results clearly suggest that the W (or neo-W) chromosome of S. cynthia ssp. plays no role in sex determination and reproduction, and thus does not contribute to the formation of reproductive barriers between different subspecies.
Data from: Novel evolutionary pathways of sex-determining mechanisms
Evolutionary transitions between sex-determining mechanisms (SDMs) are an enigma. Among vertebrates, individual sex (male or female) is primarily determined by either genes (genotypic sex determination, GSD) or embryonic incubation temperature (temperature-dependent sex determination, TSD), and these mechanisms have undergone repeated evolutionary transitions. Despite this evolutionary lability, transitions from GSD (i.e. from male heterogamety, XX/XY, or female heterogamety, ZZ/ZW) to TSD are an evolutionary conundrum, as they appear to require crossing a fitness valley arising from the production of genotypes with reduced viability owing to being homogametic for degenerated sex chromosomes (YY or WW individuals). Moreover, it is unclear whether alternative (e.g. mixed) forms of sex-determination can persist across evolutionary time. It has previously been suggested that transitions would be easy if temperature-dependent sex-reversal (e.g. XX male or XY female) were asymmetrical, occurring only in the homogametic sex. However, only recently has a mechanistic model of sex determination emerged that may allow such asymmetrical sex-reversal. We demonstrate that selection for TSD in a realistic sex-determining system can readily drive evolutionary transitions from GSD to TSD that do not require the production of YY or WW individuals. In XX /XY systems, sex-reversal (female to male) occurs in a portion of the XX individuals only, leading to the loss of the Y allele (or chromosome) from the population as XX individuals mate with each other. The outcome is a population of XX individuals whose sex is determined by incubation temperature (TSD). Moreover, our model reveals a novel evolutionarily stable state representing a mixed-mechanism system that has not been revealed by previous approaches. This study solves two long-standing puzzles of the evolution of sex-determining mechanisms by illuminating the evolutionary pathways and endpoints.
Study to Determine Safety and Effectiveness of Tadalafil on Prostate Related Sex Organ/Urinary Tract Problems
ClinicalTrials.gov study NCT00547625. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Sex-specific Determinants of Early-phase Recovery From Skeletal Muscle Disuse
ClinicalTrials.gov study NCT04151901. IPD Sharing: YES. Countries: 1. Publications: 0.
A Y-chromosome-encoded small RNA acts as sex determinant in persimmons
GEO Series GSE61386. Diospyros lotus. 24 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
Data from: The fate of W chromosomes in hybrids between wild silkmoths, Samia cynthia ssp.: no role in sex determination and reproduction
Open the record for dataset details and reuse information.
Data from: Novel evolutionary pathways of sex-determining mechanisms
Open the record for dataset details and reuse information.
The master male sex determinant Gdf6Y of the turquoise killifish arose through allelic neofunctionalization [Human]
GEO Series GSE233992. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Uncoupling X chromosome number from sex determination separates contribution of sex and X dose to sex-biased gene expression in C. elegans
GEO Series GSE77794. Caenorhabditis elegans. 14 samples. Type: Expression profiling by high throughput sequencing.
Flower development and sex determination in Vernicia fordii
GEO Series GSE98631. Vernicia fordii. 6 samples. Type: Expression profiling by high throughput sequencing.
Transcriptome analysis of different developmental stages of Daphnia similoides sinensis and screening of male sex determination candidate genes
GEO Series GSE197943. Daphnia sinensis. 8 samples. Type: Expression profiling by high throughput sequencing.
The Wright Stuff: Reimagining Path Analysis Reveals Novel Components of the Sex Determination Hierarchy in Drosophila Melanogaster
GEO Series GSE67400. Drosophila melanogaster. 9 samples. Type: Expression profiling by high throughput sequencing.
New candidate gene identification for controlling mammalian gonadal sex determination
GEO Series GSE18211. Mus musculus. 12 samples. Type: Expression profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.