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592 results for “tendon”
Long Duration Therapeutic Ultrasound for Tendon Healing
ClinicalTrials.gov study NCT02466308. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Inferior Oblique Myectomy Versus Anterior and Nasal Transposition of Its Tendon for Treatment of Superior Oblique Muscle Palsy
ClinicalTrials.gov study NCT05031312. IPD Sharing: NO. Countries: 1. Publications: 9.
Development of Achilles Tendon Elongation and Its Effect on Physical Function the First Year After Rupture
ClinicalTrials.gov study NCT03525314. IPD Sharing: NO. Countries: 1. Publications: 1.
The Effect of Microfracture Procedure on Rotator Cuff Tendon Healing
ClinicalTrials.gov study NCT04421417. IPD Sharing: NO. Countries: 1. Publications: 5.
Data from: Muscle-tendon mechanics explain unexpected effects of exoskeleton assistance on metabolic rate during walking
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Data from: Morphological and mechanical properties of the human triceps surae aponeuroses taken from elderly cadavers: implications for muscle-tendon interactions
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Data from: Changes in morphological and elastic properties of patellar tendon in athletes with unilateral patellar tendinopathy and their relationships with pain and functional disability
Background: Patellar tendinopathy (PT) is one of the most common knee disorders among athletes. Changes in morphology and elasticity of the painful tendon and how these relate to the self-perceived pain and dysfunction remain unclear. Objectives: To compare the morphology and elastic properties of patellar tendons between athlete with and without unilateral PT and to examine its association with self-perceived pain and dysfunction. Methods: In this cross-sectional study, 33 male athletes (20 healthy and 13 with unilateral PT) were enrolled. The morphology and elastic properties of the patellar tendon were assessed by the grey and elastography mode of supersonic shear imaging (SSI) technique while the intensity of pressure pain, self-perceived pain and dysfunction were quantified with a 10-lb force to the most painful site and the Victorian Institute of Sport Assessment-patella (VISA-P) questionnaire, respectively. Results: In athletes with unilateral PT, the painful tendons had higher shear elastic modulus (SEM) and larger tendon than the non-painful side (p<0.05) or the dominant side of the healthy athletes (p<0.05). Significant correlations were found between tendon SEM ratio (SEM of painful over non-painful tendon) and the intensity of pressure pain (rho = 0.62; p = 0.024), VISA-P scores (rho = −0.61; p = 0.026), and the sub-scores of the VISA-P scores on going down stairs, lunge, single leg hopping and squatting (rho ranged from −0.63 to −0.67; p<0.05). Conclusions: Athletes with unilateral PT had stiffer and larger tendon on the painful side than the non-painful side and the dominant side of healthy athletes. No significant differences on the patellar tendon morphology and elastic properties were detected between the dominant and non-dominant knees of the healthy control. The ratio of the SEM of painful to non-painful sides was associated with pain and dysfunction among athletes with unilateral PT.
Data from: Muscle-tendon unit length changes differ between young and adult sprinters in first stance phase of sprint running
The aim of this study was to compare young and adult sprinters on several biomechanical parameters that were previously highlighted as performance-related and to determine the behaviour of several muscle-tendon units (MTU) in the first stance phase following a block start in sprint running. The ground reaction force (GRF) and kinematic data were collected from 16 adult and 21 young well-trained sprinters. No difference between the groups was found in some of the previously-highlighted performance-related parameters (ankle joint stiffness, the range of dorsiflexion and plantar flexor moment). Interestingly, the young sprinters showed a greater maximal and mean ratio of horizontal to total GRF, which was mainly attributed to a greater horizontal GRF relative to body mass and resulted in a greater change in horizontal centre of mass (COM) velocity during the stance phase in the young compared to the adult sprinters.. Results from the MTU length analyses showed that adult sprinters had more MTU shortening and higher maximal MTU shortening velocities in all plantar flexors and the rectus femoris. Although previously-highlighted performance-related parameters could not explain the greater 100 m sprinting times in the adult sprinters, differences were found in the behaviour of the MTU of the plantar flexors and rectus femoris during the first stance phase. The pattern of length changes in these MTUs provide ideal conditions for the use of elastic energy storage and release for power enhancement.
Data from: Fascicles from energy-storing tendons show an age-specific response to cyclic fatigue loading
Some tendons, such as the human Achilles and equine superficial digital flexor tendon (SDFT), act as energy stores, stretching and recoiling to increase efficiency during locomotion. Our previous observations of rotation in response to applied strain in SDFT fascicles suggest a helical structure, which may provide energy-storing tendons with a greater ability to extend and recoil efficiently. Despite this specialization, energy-storing tendons are prone to age-related tendinopathy. The aim of this study was to assess the effect of cyclic fatigue loading (FL) on the microstructural strain response of SDFT fascicles from young and old horses. The data demonstrate two independent age-related mechanisms of fatigue failure; in young horses, FL caused low levels of matrix damage and decreased rotation. This suggests that loading causes alterations to the helix substructure, which may reduce their ability to recoil and recover. By contrast, fascicles from old horses, in which the helix is already compromised, showed greater evidence of matrix damage and suffer increased fibre sliding after FL, which may partially explain the age-related increase in tendinopathy. Elucidation of helix structure and the precise alterations occurring owing to both ageing and FL will help to develop appropriate preventative and repair strategies for tendinopathy.
RNA-seq for sham and injured murine tendon tissues
<p>RNA-seq for sham and injured murine tendon tissues</p>
Data from: Resilin in the flight apparatus of Odonata (Insecta) – cap tendons and their biomechanical importance for the flight
In Odonata, a direct flight mechanism with specialised tendons evolved. One particular adaptation, the implementation of the rubber-like protein resilin in these cap tendons might be of major importance. Although, resilin was firstly described in one tendon of Odonata, no comprehensive study about the presence of resilin in the thorax exists yet. We investigated various species of Odonata, using µCT, dissection and fluorescence microscopy. Here we show a complete mapping of the odonatan pterothorax, regarding the presence of tendons and their properties. Thus, 20-21 cap tendons in the pterothorax of Odonata show the presence of resilin. While performing outstanding and often aggressive flight manoeuvres, resilin can provide shock absorption against mechanical damage from strong impacts. It may further improve the wear and fatigue resistance due to resilin's damping behaviour. Additionally, resilin in tendons can absorb and return kinetic energy to restore muscles to their original shape after contracting and help maintaining self-oscillation of the flight muscles. Here the material distribution within the direct flight system of Odonata and the biomechanical importance and possible function of resilin is discussed. These results are an important step towards the understanding of the complex form-material-function interplay of the insect cuticle.
Data from: The tendinopathic Achilles tendon does not remain iso-volumetric upon repeated loading: insights from 3D ultrasound
Mid-portion Achilles tendinopathy (MAT) alters the normal three-dimensional (3D) morphology of the Achilles tendon (AT) at rest and under a single tensile load. However, how MAT changes the 3D morphology of the AT during repeated loading remains unclear. This study compared the AT longitudinal, transverse and volume strains during repeated loading of the tendinopathic AT with those of the contralateral tendon in people with unilateral MAT. Ten adults with unilateral MAT performed 10 successive 25 s submaximal (50%) voluntary isometric plantarflexion contractions with both legs. Freehand 3D ultrasound scans were recorded and used to measure whole AT, free AT and proximal AT longitudinal strains and free AT cross-sectional area (CSA) and volume strains. The free AT experienced higher longitudinal and CSA strain and reached steady state following a greater number of contractions (five contractions) in the tendinopathic AT compared with the contralateral tendon (three contractions). Further, free tendon CSA and volume strain were greater in the tendinopathic AT than in the contralateral tendon from the first contraction, whereas free AT longitudinal strain was not greater than that of the contralateral tendon until the fourth contraction. Volume loss from the tendon core therefore preceded the greater longitudinal strain in the tendinopathic AT. Overall, these findings suggest that the tendinopathic free AT experiences an exaggerated longitudinal and transverse strain response under repeated loading that is underpinned by an altered interaction between solid and fluid tendon matrix components. These alterations are indicative of accentuated poroelasticity and an altered local stress–strain environment within the tendinopathic free tendon matrix, which could affect tendon remodelling via mechanobiological pathways.
Figure 4 from: Žnidaršič N, Mrak P, Tušek-Žnidarič M, Strus J (2012) Exoskeleton anchoring to tendon cells and muscles in molting isopod crustaceans. ZooKeys 176: 39-53. https://doi.org/10.3897/zookeys.176.2445
Figure 4 - Overview of exoskeleton anchoring to tendon cells and muscles in intramarsupial developmental stages of Porcellio scaber. In prehatching embryos (4A, B) and in premolt marsupial mancas (4C a semithin section and 4D) the connections between the exoskeleton, tendon cells and muscle cells were already established. EX exoskeleton ES ecdysal space NC new cuticle TC tendon cell MC muscle cell.
Figure 5 from: Žnidaršič N, Mrak P, Tušek-Žnidarič M, Strus J (2012) Exoskeleton anchoring to tendon cells and muscles in molting isopod crustaceans. ZooKeys 176: 39-53. https://doi.org/10.3897/zookeys.176.2445
Figure 5 - Anchoring junctions between the detached cuticle and the apical part of tendon cells in the prehatching embryo (5A, D, E) and marsupial mancas (5B, C, F) of Porcellio scaber (ultrathin cross-sections). The newly forming cuticle in marsupial mancas, consisting of the epicuticle and pre-ecdysal procuticle, was mechanically connected to tendon cells. Numerous bundles of fibers (arrows) running from tendon cells through the new cuticle and ecdysal space into the detached cuticle are evident. Microtubules were found in close proximity to electron dense plaques at the apical surface of tendon cells. DC detached cuticle NC new cuticle EC epicuticle ES ecdysal space PP pre-ecdysal procuticle TC tendon cell Mt microtubules.
Figure 1 from: Žnidaršič N, Mrak P, Tušek-Žnidarič M, Strus J (2012) Exoskeleton anchoring to tendon cells and muscles in molting isopod crustaceans. ZooKeys 176: 39-53. https://doi.org/10.3897/zookeys.176.2445
Figure 1 - A scheme showing the general architecture of the muscle attachment to the epidermis in arthropods (adapted from Mellon 1992, Lai-Fook and Beaton 1998, Bitsch and Bitsch 2002 and Subramanian et al. 2003). Specialized epithelial cells, named tendon cells, are anchored apically to the cuticle and basally to the muscle cell. aAJ apical adherens junction bAJ basal adherens junction icF intracuticular fibers Mf myofilaments Mt microtubules.
Figure 3 from: Žnidaršič N, Mrak P, Tušek-Žnidarič M, Strus J (2012) Exoskeleton anchoring to tendon cells and muscles in molting isopod crustaceans. ZooKeys 176: 39-53. https://doi.org/10.3897/zookeys.176.2445
Figure 3 - Myotendinous junction in the dorsal parts of pereonites of premolt adult Ligia italica is an extensive anchoring junction. The entire zigzag folded basal and apical membranes of tendon and muscle cells, respectively, are engaged in this outstanding intercellular mechanical connection (3A). Prominent electron dense cytoplasmic plaques are evident along both cell membranes, separated by a thin layer of extracellular matrix (3B). MC muscle cell TC tendon cell.
Figure 7 from: Žnidaršič N, Mrak P, Tušek-Žnidarič M, Strus J (2012) Exoskeleton anchoring to tendon cells and muscles in molting isopod crustaceans. ZooKeys 176: 39-53. https://doi.org/10.3897/zookeys.176.2445
Figure 7 - Myotendinous junction in the Porcellio scaber prehatching embryo (7A, B) and marsupial mancas (7C, D). The cytoplasmic plaque of the anchoring junction at the basal membrane of tendon cell is more lucent and thinner than the accompanying plaque at the apical membrane of the muscle cell in the prehatching embryo (7A, B). Microtubules of the tendon cells are in close proximity to the basal dense plaques. TC tendon cell MC muscle cell Mt microtubules Myf myofilaments.
Figure 2 from: Žnidaršič N, Mrak P, Tušek-Žnidarič M, Strus J (2012) Exoskeleton anchoring to tendon cells and muscles in molting isopod crustaceans. ZooKeys 176: 39-53. https://doi.org/10.3897/zookeys.176.2445
Figure 2 - Exoskeleton – muscle attachment in the dorsal parts of pereonites in adult premolt Ligia italica. Overview of the muscle attachment in a specimen with a detached and a newly forming cuticle (2A a semithin section). The new cuticle is extensively connected to the underlying tendon cells already in the early premolt. Fibrous connections running from the apical region of tendon cells through the new pre-ecdysal cuticle and ecdysal space up to the exocuticle of the detached exoskeleton are evident (2B, C). Parallel arrays of microtubules and apical electron dense plaques are characteristic for tendon cells (2D). DC detached cuticle NC new cuticle ES ecdysal space MC muscle cell TC tendon cell Mt microtubules; arrowheads – fibrous connections.
Figure 6 from: Žnidaršič N, Mrak P, Tušek-Žnidarič M, Strus J (2012) Exoskeleton anchoring to tendon cells and muscles in molting isopod crustaceans. ZooKeys 176: 39-53. https://doi.org/10.3897/zookeys.176.2445
Figure 6 - Electron dense plaques (hemidesmosome-like structures) at the apical surface of the tendon cells in the marsupial manca of Porcellio scaber. Electron dense plaques (arrows) are associated with microtubules (Mt) in the cytoplasm of the tendon cell and with the bundles of fibers (F) running through the ecdysal space (ES) on the opposite side. DC detached cuticle NC new cuticle.
Achilles Tendon Repair With Bioinductive Implant
ClinicalTrials.gov study NCT02811003. IPD Sharing: NO. Countries: 1. Publications: 0.
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Allen Brain Atlas
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