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236 results for “venom”
Genetic characterization of potential venom resistance proteins in California ground squirrels (Otospermophilus beecheyi) using transcriptome analyses
Open the record for dataset details and reuse information.
RNA sequencing of venom glands and venom gland organoids
GEO Series GSE129581. Naja nivea; Aspidelaps lubricus cowlesi. 15 samples. Type: Expression profiling by high throughput sequencing.
A phylogenetic approach to the recruitment of venom proteins in a marine Polychaeta
GEO Series GSE143954. Eulalia viridis. 6 samples. Type: Expression profiling by high throughput sequencing.
Neurocellular stress response to Mojave Type A Rattlesnake venom: A study of molecular mechanisms using a human iPSC-derived neural stem cell model
GEO Series GSE287744. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
Molecular dissection of cobra venom highlights heparinoids as an effective snakebite antidote
GEO Series GSE262798. Homo sapiens. 8 samples. Type: Other.
A core set of venom proteins are secreted by entomopathogenic nematodes in the genus Steinernema
GEO Series GSE119223. Steinernema feltiae. 27 samples. Type: Expression profiling by high throughput sequencing.
Agelena koreana whole body and venom gland transcriptome
GEO Series GSE197102. Agelena koreana. 6 samples. Type: Expression profiling by high throughput sequencing.
Activated entomopathogenic nematode infective juveniles release lethal venom proteins
GEO Series GSE89961. Steinernema carpocapsae. 15 samples. Type: Expression profiling by high throughput sequencing.
Investigating patterns of chromatin accessibility, histone modifications, and insulation involved in rattlesnake venom gene regulation
GEO Series GSE169217. Crotalus viridis. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Mapping the immune cell microenvironment by digital spatial profiling in muscle tissue injected with the venom of Daboia russelii
GEO Series GSE222977. Mus musculus. 63 samples. Type: Other.
VenomSeq - 25 venoms vs. IMR-32
GEO Series GSE126575. Homo sapiens. 192 samples. Type: Expression profiling by high throughput sequencing.
Figure 1 in Noxious arthropods as potential prey of the venomous Javan slow loris (Nycticebus javanicus) in a West Javan volcanic agricultural system
Figure 1. Map of the study location Cipaganti near Garut, West Java.
Beyond sexual maturity: Importance of dietary changes in venom variation in Vipera ammodytes
<p>This study explores venom variation in the nose-horned viper (<em>Vipera ammodytes</em>) across different body sizes, examining its relationship with dietary shifts and reproductive status.</p> <p>This data set includes MALDI-TOF-MS data from 40 crude <em>V. ammodytes</em> venoms (folder Lakusic_et_al_MALDI_data.zip)</p> <p>Used instrument: MALDI-ToF/ToF mass spectrometer (ultrafleXtreme, Bruker Daltonics, Bremen, Germany)</p>
Diversely evolved xibalbin variants from remipede venom inhibit 3 potassium channels and activate PKA-II and Erk1/2 signalling
<p><span><strong>Background:</strong> </span><span>The identification of novel toxins from overlooked and taxonomically exceptional species bears potential for various pharmacological applications. The remipede <em>Xibalbanus tulumensis</em>, an underwater cave-dwelling crustacean, is the only crustacean for which a venom system has been described. Its venom contains several xibalbin peptides that have an inhibitor cysteine knot (ICK) scaffold.</span></p> <p><strong><span>Result:</span></strong><span><strong> </strong>Our screenings revealed that all tested xibalbin variants particularly inhibit potassium channels. Xib<sub>1</sub> and xib<sub>13</sub>, with their eight-cysteine domain similar to spider knottins also inhibit voltage-gated sodium channels. No activity was noted on calcium channels. Expanding the functional testing we demonstrate that xib<sub>1</sub> and xib<sub>13</sub> increase PKA-II and Erk1/2 sensitization signaling in nociceptive neurons, which may initiate pain sensitization. Our phylogenetic analysis suggests that xib<sub>13</sub> either originates from the common ancestor of pancrustaceans or earlier while xib<sub>1</sub> is more restricted to remipedes. The ten-cysteine scaffolded xib<sub>2</sub> emerged from xib<sub>1</sub>, a result that is supported by our phylogenetic and machine learning-based analyses.</span></p> <p><strong><span>Conclusions</span></strong><span><strong>: </strong>Our functional characterization of synthesized variants of xib<sub>1</sub>, xib<sub>2</sub>, and xib<sub>13</sub> elucidates their potential as inhibitors of potassium channels in mammalian systems. The specific interaction of xib<sub>2</sub> with Kv1.6 channels, which are relevant to treating variants of epilepsy, shows potential for further studies. At higher concentrations, xib1 and xib13 activate the kinases PKA-II and ERK1/2 in mammalian sensory neurons, suggesting pain sensitization and potential applications related to pain research and therapy. While tested insect channels suggest that all probably act as neurotoxins, the biological function of xib<sub>1</sub>, xib<sub>2,</sub> and xib<sub>13</sub> requires further elucidation. A novel finding on their evolutionary origin is the apparent emergence of </span><em><span>X. tulumensis</span></em><span>-specific xib<sub>2</sub> from xib<sub>1</sub>. Our study is an important cornerstone for future studies to untangle the origin and function of these enigmatic proteins as important components of remipede but also other pancrustacean and arthropod venoms.</span></p>
Mechanisms underpinning the permanent muscle damage induced by snake venom metalloprotease
<p>The data presented in the 2018 paper "Mechanisms underpinning the permanent muscle damage induced by snake venom metalloprotease" published in PLOS NTD.</p>
Determination of Reference Values for Diluted Russell's Viper Venom Time (dRVVT) Specific to Pregnant Women (GRAPL)
ClinicalTrials.gov study NCT06133621. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Bee Venom Phonophoresis on Mild to Moderate Localized Plaque Psoriasis on Knee Joint
ClinicalTrials.gov study NCT06106230. IPD Sharing: NO. Countries: 1. Publications: 0.
Phonophoresis With Bee Venom: Evaluating Its Efficacy in Managing Pain and Enhancing Mobility in Knee Osteoarthritis Patients
ClinicalTrials.gov study NCT07151300. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Jack Jumper Ant Venom Immunotherapy Long-term Effectiveness Investigation
ClinicalTrials.gov study NCT06935890. IPD Sharing: YES. Countries: 1. Publications: 0.
Omalizumab Treatment in Venom Immunotherapy With Systemic Reactions
ClinicalTrials.gov study NCT02968394. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.