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14,866 results for “cancer cell”
Supplementary material 3 from: Khalaf WY, Elias RS, Raheem LA (2023) Design, synthesis and molecular docking study of coumarin pyrazoline derivatives against MCF-7 breast cancer cell line. Pharmacia 70(4): 1497-1492. https://doi.org/10.3897/pharmacia.70.e108670
Data synthesis compounds, physicochemical properties and identification of synthesis compound
Supplementary material 1 from: Khalaf WY, Elias RS, Raheem LA (2023) Design, synthesis and molecular docking study of coumarin pyrazoline derivatives against MCF-7 breast cancer cell line. Pharmacia 70(4): 1497-1492. https://doi.org/10.3897/pharmacia.70.e108670
Synthesis compounds
Supplementary material 2 from: Khalaf WY, Elias RS, Raheem LA (2023) Design, synthesis and molecular docking study of coumarin pyrazoline derivatives against MCF-7 breast cancer cell line. Pharmacia 70(4): 1497-1492. https://doi.org/10.3897/pharmacia.70.e108670
Docking study
Pathological images of non-small cell lung cancer
<p>The dataset comprises lung cancer patient information and pathology images utilized for the analysis of our study. These are anonymized data from cases in our cohort for which patient consent was obtained for public deposition. </p> <p>Patient information for original cohort and validation cohort is described in the Excle files, "original_cohort_patient_info.xlsx" and "validation_cohort_patient_info.xlsx", respectively. </p> <p>These Excel files contain information on sex, age, smoking history, pathological stage, histology, lymphovascular invasion, pleural invasion, lymph node metastasis, adjuvant treatment, survival outcomes and file names for pathological images of each patient. Each patient has two files of Whole Slide Images files (format: .npdi) including hematoxylin & eosin staining ("XXX_h.ndpi") and immunohistochemistry stainig for PD-L1 ("XXX_p.ndpi").</p>
Integration of Single-Cell Analysis and Mendelian Randomization Reveals NET1 as a Potential Key Player in Lung Cancer Pathogenesis
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Gene expression analysis of KRAS knockout pancreatic cancer cell line CFPAC1
<p>We used CRISPR to inactivate mutant KRAS in CFPAC1 (KRASG12V) pancreatic cancer cell lines. Gene expression analysis of KRAS intact vs. knockout cells identified sets of genes involved in protein synthesis, cell differentiation, and metabolic processes, while the expression of MAPK/ERK target genes remained unperturbed.</p>
OrganoIDNetData: A Curated Cell Life Imaging Dataset of Immune-enriched Pancreatic Cancer Organoids with Pre-trained AI Models
<p>OrganoIDNetData encompasses 180 images with 34113 organoids of human and murine Pancreatic Ductal Adenocarcinoma co-cultured with immune cells.</p> <p><strong>For further information and to cite this dataset, please refer to:</strong></p> <p>Kulkarni, A., Ferreira, N., Scodellaro, R. <em>et al.</em> A Curated Cell Life Imaging Dataset of Immune-enriched Pancreatic Cancer Organoids with Pre-trained AI Models. <em>Sci Data</em> <strong>11</strong>, 820 (2024). https://doi.org/10.1038/s41597-024-03631-3</p>
Raw data of the article:Proof-of-Concept Study on the Use of Tangerine-Derived Nanovesicles as siRNA Delivery Vehicles toward Colorectal Cancer Cell Line SW480
<p>In the last years, the field of nanomedicine and drug delivery has grown exponentially, providing new platforms to carry therapeutic agents into the target sites. Extracellular vesicles (EVs) are ready-to-use, biocompatible, and non-toxic nanoparticles that are revolutionizing the field of drug delivery. EVs are involved in cell-cell communication and mediate many physiological and pathological processes by transferring their bioactive cargo to target cells. Recently, nanovesicles from plants (PDNVs) are raising the interest of the scientific community due to their high yield and biocompatibility. This study aims to evaluate whether PDNVs may be used as drug delivery systems. We isolated and characterized nanovesicles from tangerine juice (TNVs) that were comparable to mammalian EVs in size and morphology. TNVs carry the traditional EV marker HSP70 and, as demonstrated by metabolomic analysis, contain flavonoids, organic acids, and limonoids. TNVs were loaded with DDHD1-siRNA through electroporation, obtaining a loading efficiency of 13%. We found that the DDHD1-siRNA complex TNVs were able to deliver DDHD1-siRNA to human colorectal cancer cells, inhibiting the target expression by about 60%. This study represents a proof of concept for the use of PDNVs as vehicles of RNA interference (RNAi) toward mammalian cells.</p>
Figure 2 from: Hartati FK, Nafisah W, Sutanto A, Saati EA, Khairoh M, Sjamsiah (2024) Aqueous black rice (Oryza sativa L. indica) extract enhanced the activation of CD4+ and CD8+ T cells in mouse breast cancer model. Pharmacia 71: 1-7. https://doi.org/10.3897/pharmacia.71.e113442
Figure 2 Aqueous black rice (ABR) extract reduced the relative number of CD4+IL17+, CD4+TNFα+, and CD4+IFNγ+ cytokine production. A, C, E. were flow cytometry diagram; B, D, F. were the graph of flow cytometry results. The bar in the graph shows the calculation results as the mean ± SD of the relative number of cytokine production. *P<0.05, indicate significant different. The group in this study were normal group; Cancer, DMBA 15 mg/kg BW; Cis, DMBA 15 mg/kg BW + Cisplatin 5 mg/kg BW; ABR1, DMBA 15 mg/kg BW + aqueous black rice extract 0.2 g/kg BW; ABR2, DMBA 15 mg/kg BW + aqueous black rice extract 0.3 g/kg BW; ABR3, DMBA 15 mg/kg BW + aqueous black rice extract 0.4 g/kg BW; ABR4, DMBA 15 mg/kg BW + aqueous black rice extract 0.5 g/kg BW.
Figure 1 from: Hartati FK, Nafisah W, Sutanto A, Saati EA, Khairoh M, Sjamsiah (2024) Aqueous black rice (Oryza sativa L. indica) extract enhanced the activation of CD4+ and CD8+ T cells in mouse breast cancer model. Pharmacia 71: 1-7. https://doi.org/10.3897/pharmacia.71.e113442
Figure 1 Aqueous black rice (ABR) extract increased the relative number of CD4+CD62L- cells and CD8+CD62L- cells. A, C. Show flow cytometry diagrams, and B, D. Show graphs of the flow cytometry results. The bars in the graphs show the calculated results as the mean ± SD of the relative number of CD4+ and CD8+ cell activations. *P<0.05 indicates a significant difference. The groups in this study included the following groups: Normal; Cancer, DMBA 15 mg/kg BW; Cis, DMBA 15 mg/kg BW + Cisplatin 5 mg/kg BW; ABR1, DMBA 15 mg/kg BW + ABR extract 0.2 g/kg BW; ABR2, DMBA 15 mg/kg BW + ABR extract 0.3 g/kg BW; ABR3, DMBA 15 mg/kg BW + ABR extract 0.4 g/kg BW; and ABR4, DMBA 15 mg/kg BW + ABR extract 0.5 g/kg BW.
Figure 3 from: Hartati FK, Nafisah W, Sutanto A, Saati EA, Khairoh M, Sjamsiah (2024) Aqueous black rice (Oryza sativa L. indica) extract enhanced the activation of CD4+ and CD8+ T cells in mouse breast cancer model. Pharmacia 71: 1-7. https://doi.org/10.3897/pharmacia.71.e113442
Figure 3 Aqueous black rice (ABR) extract effect on mammary mice histology based on Hematoxylin & Eosin staining (M: 400x). D, ductal; AT, adipose tissue; arrow, cancer cell. The group in this study were normal group; Cancer, DMBA 15 mg/kg BW; Cis, DMBA 15 mg/kg BW + Cisplatin 5 mg/kg BW; ABR1, DMBA 15 mg/kg BW + aqueous black rice extract 0.2 g/kg BW; ABR2, DMBA 15 mg/kg BW + aqueous black rice extract 0.3 g/kg BW; ABR3, DMBA 15 mg/kg BW + aqueous black rice extract 0.4 g/kg BW; ABR4, DMBA 15 mg/kg BW + aqueous black rice extract 0.5 g/kg BW.
Fig. 3. X in Undescribed isoquinolines from Zanthoxylum nitidum and their antiproliferative effects against human cancer cell lines
Fig. 3. X-ray ORTEP drawing of 1 and 23.
Data from: Downregulation of circATXN7 represses non-small cell lung cancer growth by releasing miR-7-5p
<p>Circular RNAs (circRNAs) participate in the occurrence and progression of many cancers. CircRNA ataxin 7 (circATXN7) (circBase ID: hsa_circ_0066436) plays a promoting influence on gastric cancer progression. However, the biological role of circATXN7 in non-small cell lung cancer (NSCLC) is indistinct. CircATXN7 and PFN2 were highly expressed in NSCLC, whereas miR-7-5p expression had the opposite trend. CircATXN7 overexpression constrained apoptosis and promoted proliferation, metastasis, invasion, and epithelial-mesenchymal transition (EMT) of NSCLC cells, but circATXN7 silencing played the opposing influence and repressed xenograft tumor growth <i>in vivo</i>. CircATXN7 served as a miR-7-5p sponge, and circATXN7 regulated malignant behaviors of NSCLC cells through sponging miR-7-5p. PFN2 acted as a miR-7-5p target. PFN2 silencing overturned the promoting effect of miR-7-5p inhibitor on NSCLC cell malignancy, while PFN2 overexpression reversed the inhibitory impact of miR-7-5p mimic on NSCLC cell malignancy. CircATXN7 accelerated the malignancy of NSCLC cells through adsorbing miR-7-5p and upregulating PFN2, offering evidence to support circATXN7 as a might target for NSCLC treatment.</p>
Harmonized cancer and normal datasets, as well as the dataset for the BT474 cell line samples
<p>Harmonized cancer and normal datasets, as well as the dataset for the BT474 cell line samples</p>
Spatial distribution pattern of immune cells is associated with patient prognosis in colorectal cancer
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Triple-negative breast cancer and Natural killer cells
SciDraw 6 Drawing Upload
Triple-negative breast cancer and Natural killer cells
SciDraw 6 Drawing Upload
AEG-1 inhibits proliferation and invasion of colorectal cancer HCT116 cells via the PI3K/AKT/mTOR pathway
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Imada Fasting Cancer - single cell RNA-Seq Processed Data R object
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Dataset #2 related to article "NaCl enhances CD8+ T-cell effector functions in cancer immunotherapy"
<p><span>CD8<sup>+</sup> T cells control tumors but inevitably become dysfunctional. Ionic metabolism is emerging as a regulator of CD8<sup>+</sup> T cells in anti-tumor immunity. We show that sodium chloride (NaCl) counteracts T-cell dysfunction to promote cancer regression. NaCl supplementation during CD8<sup>+</sup> T-cell culture induced potent effector differentiation, IFN-</span><span>g</span><span> production and cytotoxicity while maintaining gene networks responsible for stem-like plasticity. Accordingly, adoptive transfer of tumor-specific T cells resulted in superior anti-tumor immunity in a humanized model. In mice, high-salt diet reduced growth of experimental tumors in a CD8<sup>+</sup> T cell-dependent manner, by inhibiting terminal differentiation, and by enhancing the effector potency of CD8<sup>+</sup> T cells. Mechanistically, NaCl enhanced glutamine consumption that was critical for transcriptional, epigenetic and functional reprogramming. In humans, CD8<sup>+</sup> T cells undergoing antigen recognition in tumors and predicting favorable response to checkpoint blockade immunotherapy resembled those induced by NaCl. Thus, NaCl metabolism is a major regulator of CD8<sup>+</sup> T-cell effector function, with potential translation in cancer immunotherapy.</span></p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.