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2,709
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Dataset results
2,709 results for “Mouse Model”
Gene expression profiles of spontaneous metastasis in a K-ras/p53 mutant mouse model
GEO Series GSE14449. Mus musculus. 16 samples. Type: Expression profiling by array.
Role of Epstein-Barr Virus (EBV) latency protein EBNA3C in EBV-induced lymphomagenesis in a cord blood-humanized mouse model
GEO Series GSE113070. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Paternal malnutrition programs offspring’s breast cancer risk and tumor metabolism in a mouse model
GEO Series GSE114423. Mus musculus. 27 samples. Type: Non-coding RNA profiling by high throughput sequencing; Methylation profiling by high throughput sequencing.
MyoD-Cre driven alterations in K-Ras and p53 lead to a mouse model with histological and molecular characteristics of human rhabdomyosarcoma
GEO Series GSE195923. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
Insights into RNA‐mediated pathology in new mouse models of Huntington's disease
GEO Series GSE269068. Mus musculus. 12 samples. Type: Expression profiling by array.
Bcl9 and Pygo synergize downstream of Apc to effect intestinal neoplasia in mouse models recapitulating Familial Adenomatous Polyposis
GEO Series GSE121145. Mus musculus. 38 samples. Type: Expression profiling by high throughput sequencing; Expression profiling by array.
Type I Interferon Signaling Mediates Microglial Dysfunction and Senescence in Human-Mouse Chimeric Brain Models of Down Syndrome and Alzheimer’s Disease
GEO Series GSE189227. Mus musculus; Homo sapiens. 10 samples. Type: Expression profiling by high throughput sequencing.
ErbB inhibition rescues nigral dopamine neuron hyperactivity and repetitive behaviors in a mouse model of fragile X syndrome
<p>This data package includes excel files containing all raw data needed to reproduce the analyses associated to the following study by D' Addario SL, Rosina E, Massaro Cenere M, Bagni C, Mercuri NB, Ledonne A: "<em>ErbB inhibition rescues nigral dopamine neuron hyperactivity and repetitive behaviors in a mouse model of fragile X syndrome</em>" (preprint doi: https://doi.org/10.1101/2024.02.23.581801). </p>
Data from: Sensory-Behavioral Deficits in Parkinson's Disease: Insights from a 6-OHDA Mouse Model
<table> <tbody> <tr> <td>Parkinson's disease (PD) is characterized by the degeneration of dopaminergic neurons in the striatum, predominantly associated with motor symptoms. However, non-motor deficits, particularly sensory symptoms, often precede motor manifestations, offering a potential early diagnostic window. The impact of non-motor deficits on sensation behavior and the underlying mechanisms remains poorly understood. In this study, we examined changes in tactile sensation within a Parkinsonian state by employing a mouse model of PD induced by 6-hydroxydopamine (6-OHDA) to deplete striatal dopamine (DA). Leveraging the conserved mouse whisker system as a model for tactile-sensory stimulation, we conducted psychophysical experiments to assess sensory-driven behavioral performance during a tactile detection task in both the healthy and Parkinson-like states. Our findings reveal that DA depletion induces pronounced alterations in tactile sensation behavior, extending beyond expected motor impairments. We observed diverse behavioral deficits, spanning detection performance, task engagement, and reward accumulation, among lesioned individuals. While subjects with extreme DA depletion consistently showed severe sensory behavioral deficits, others with substantial DA depletion displayed minimal changes in sensory behavior performance. Moreover, some exhibited moderate degradation of behavioral performance, likely stemming from sensory signaling loss rather than motor impairment. The implementation of a sensory detection task is a promising approach to quantify the extent of impairments associated with DA depletion in the animal model. This facilitates the exploration of early non-motor deficits in PD, emphasizing the importance of incorporating sensory assessments in understanding the diverse spectrum of PD symptoms.</td> </tr> </tbody> </table>
Data from: Striatal lateral inhibition regulates action selection in a mouse model of levodopa-induced dyskinesia
<p>Data from: Twedell, Bair-Marshall, Girasole, Scaria, Sridhar, & Nelson (2024) <span>Striatal lateral inhibition regulates action selection in a mouse model of levodopa-induced dyskinesia </span><span>(preprint version).</span></p>
Systematic analysis of inflammation and pain pathways in a mouse model of gout
GEO Series GSE190138. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
Identification of genes associated with breast cancer micrometastatic disease in bone marrow using a Patient Derived Xenograft mouse model
GEO Series GSE57947. Homo sapiens; Mus musculus. 11 samples. Type: Expression profiling by array.
Antileukemic Efficacy of BET Inhibitor in a Preclinical Mouse Model of MLL-AF4+ Infant ALL
GEO Series GSE79057. Homo sapiens. 28 samples. Type: Expression profiling by array.
gene expression profiling of mouse model of Helicobacter-induced gastric cancer
GEO Series GSE4651. Mus musculus. 5 samples. Type: Expression profiling by array.
Evidence that chaperone 4-PBA treatment alleviates the renal phenotype in Alport syndrome mouse models
GEO Series GSE271383. Mus musculus. 9 samples. Type: Expression profiling by RT-PCR.
Iron oxide nanoparticles inhibit tumor progression and suppress lung metastases in mouse models of breast cancer [NanoString]
GEO Series GSE261779. Mus musculus. 23 samples. Type: Other.
Anti-CX3CL1 (fractalkine) monoclonal antibody attenuates lung and skin fibrosis in sclerodermatous graft-versus-host disease mouse model
GEO Series GSE227285. Mus musculus. 19 samples. Type: Expression profiling by high throughput sequencing.
Whole blood gene expression profiles from a lupus nephritis mouse model: SNF1 (SWR X NZB F1) mice treated with pristane
GEO Series GSE86424. Mus musculus. 88 samples. Type: Expression profiling by array.
p53 constrains progression to anaplastic thyroid carcinoma in a Braf-mutant mouse model of papillary thyroid cancer.
GEO Series GSE55933. Mus musculus. 10 samples. Type: Expression profiling by array.
Limited effects of an eIF2αS51A allele on neurological impairments in the 5xFAD mouse model of Alzheimer’s disease
GEO Series GSE50521. Mus musculus. 12 samples. Type: Expression profiling by array.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.