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2,470
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ShareScore release 0.9.0
Dataset results
2,470 results for “Acute Myeloid Leukemia”
CEBPA Dysfunction Intiates CSF3R Mutant Acute Myeloid Leukemia Through Disruption of Myeloid Lineage Enhancers (RNA-seq - simultaneous)
GEO Series GSE122164. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
PBX3 cooperates with MEISI in causing rapid acute myeloid leukemia and recapitulates the core transcriptome of MLL-rearranged leukemia
GEO Series GSE68643. Mus musculus. 20 samples. Type: Expression profiling by array.
A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models
GEO Series GSE150555. Homo sapiens. 35 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Landscape of Pediatric Acute Myeloid Leukemia
Recent studies on pediatric acute myeloid leukemia (pAML) have revealed pediatric-specific driver alterations, many of which are underrepresented in the current classification schemas. To comprehensively define the genomic landscape of pAML, we systematically categorized 887 pAML into 23 mutually distinct molecular categories, including new major entities such as UBTF or BCL11B, covering 91.4% of the cohort. These molecular categories were associated with unique expression profiles and mutational patterns. For instance, molecular categories characterized by specific HOXA or HOXB expression signatures showed distinct mutation patterns of RAS pathway genes, FLT3 or WT1, suggesting shared biological mechanisms. We show that molecular categories were strongly associated with clinical outcomes using two independent cohorts, leading to the establishment of a new prognostic framework for pAML based on these updated molecular categories and minimal residual disease. Together, this comprehensive diagnostic and prognostic framework forms the basis for future classification of pAML and treatment strategies.
Pediatric Acute Myeloid Leukemia
Genomic characterization of pediatric patients with acute myeloid leukemia (AML) has led to the discovery of somatic mutations with prognostic implications. Although gene-expression profiling can differentiate subsets of pediatric AML, its clinical utility in risk stratification remains limited. Here, we evaluate gene expression, pathogenic somatic mutations, and outcome in a cohort of pediatric patients with a spectrum of pediatric myeloid-related acute leukemias for biological subtype discovery.
Inhibition of heme biosynthesis triggers cuproptosis in acute myeloid leukemia [ChIP-Seq]
GEO Series GSE303120. Mus musculus. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Oxidized 5-methylcytosine modulates synthetic lethality to poly-ADP-ribose polymerase inhibitors in acute myeloid leukemia
GEO Series GSE217587. Homo sapiens; Mus musculus. 32 samples. Type: Expression profiling by high throughput sequencing.
Parallel single-cell metabolic analysis and extracellular vesicle profiling reveal vulnerabilities with prognostic significance in acute myeloid leukemia
GEO Series GSE245810. Homo sapiens. 19 samples. Type: Expression profiling by array.
Targeting the MTF2-MDM2 Axis Sensitizes Refractory Acute Myeloid Leukemia to Chemotherapy [RNA-Seq]
GEO Series GSE98343. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Expression of HOXB genes is significantly different in acute myeloid leukemia with a partial tandem duplication of MLL vs. a MLL translocation: a cross-laboratory study
GEO Series GSE15013. Homo sapiens. 25 samples. Type: Expression profiling by array.
Mitochondrial fusion is a therapeutic vulnerability of acute myeloid leukemia [Cell lines shCTL shMFN2]
GEO Series GSE222165. Homo sapiens. 12 samples. Type: Expression profiling by array.
Gene expression profiling of CD34+/CD38- stem cells and CD34+/CD38+ progenitor cells from healthy control samples versus acute myeloid leukemia (AML) and chronic myeloid leukemia (CML)
GEO Series GSE138883. Homo sapiens. 18 samples. Type: Expression profiling by array.
Novel regions of acquired uniparental disomy discovered in acute myeloid leukemia
GEO Series GSE8721. Homo sapiens. 467 samples. Type: Genome variation profiling by SNP array; SNP genotyping by SNP array.
Whole-exome sequencing identifies mutations of BCOR in acute myeloid leukemia with normal karyotype
GEO Series GSE30442. Homo sapiens. 24 samples. Type: Expression profiling by array.
Testing the Use of Combination Therapy in Patients With Persistent Low Level Acute Myeloid Leukemia Following Initial Treatment, The ERASE Study (A MyeloMATCH Treatment Trial)
ClinicalTrials.gov study NCT05554419. IPD Sharing: YES. Countries: 0. Publications: 0.
Prognostic Biomarkers in Samples From Young Patients With Acute Myeloid Leukemia
ClinicalTrials.gov study NCT01245231. IPD Sharing: Not stated. Countries: 0. Publications: 0.
HPB-092 for the Treatment of Relapsed and Refractory Acute Myeloid Leukemia
ClinicalTrials.gov study NCT07137637. IPD Sharing: NO. Countries: 0. Publications: 0.
A Dose Finding Study of IDH305 With Standard of Care in IDH1 Mutant Acute Myeloid Leukemia
ClinicalTrials.gov study NCT02826642. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Actinium-225-Lintuzumab in Patients With Acute Myeloid Leukemia
ClinicalTrials.gov study NCT03705858. IPD Sharing: UNDECIDED. Countries: 0. Publications: 0.
Biomarkers in Samples of Bone Marrow From Patients With Acute Myeloid Leukemia
ClinicalTrials.gov study NCT01290107. IPD Sharing: Not stated. Countries: 0. Publications: 0.
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.