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Figure 6 from: Abbas AH, Mahmood AAR, Tahtamouni LH, Al-Mazaydeh ZA, Rammaha MS, Alsoubani F, Al-bayati RI (2021) A novel derivative of picolinic acid induces endoplasmic reticulum stress-mediated apoptosis in human non-small cell lung cancer cells: synthesis, docking study, and anticancer activity. Pharmacia 68(3): 679-692. https://doi.org/10.3897/pharmacia.68.e70654
Figure 6 3D View of the target compounds (5, 7A, 6B and 6C) docked against ATP binding site of EGFR kinase.
Figure 6 from: AlMotwaa SM (2021) Coupling Ifosfamide to nanoemulsion-based clove oil enhances its toxicity on malignant breast cancer and cervical cancer cells. Pharmacia 68(4): 779-787. https://doi.org/10.3897/pharmacia.68.e68291
Figure 6 Relative fluorescence intensity of nuclei at various concentrations of the studied formulas analyzed using Image J 1.43. Data are expressed as mean ± SE (n=3). Asterisks denote statistical significance (***p < 0.001 considered as very highly significant, **0.001 ≤ p < 0.01 considered as highly significant, and *0.01 ≤p < 0.05 considered as significant).
Figure 5 from: AlMotwaa SM (2021) Coupling Ifosfamide to nanoemulsion-based clove oil enhances its toxicity on malignant breast cancer and cervical cancer cells. Pharmacia 68(4): 779-787. https://doi.org/10.3897/pharmacia.68.e68291
Figure 5 Fluorescence microscopic images of changes in nuclear morphology of MCF-7 cells treated with various concentrations of the tested formulas for 24h, as revealed using DAPI stain (n = 3).
Figure 4 from: AlMotwaa SM (2021) Coupling Ifosfamide to nanoemulsion-based clove oil enhances its toxicity on malignant breast cancer and cervical cancer cells. Pharmacia 68(4): 779-787. https://doi.org/10.3897/pharmacia.68.e68291
Figure 4 Fluorescence microscopic images of changes in nuclear morphology of HeLa cells treated with various concentrations of the tested formulas for 24h, as revealed using DAPI stain (n = 3).
Figure 2 from: AlMotwaa SM (2021) Coupling Ifosfamide to nanoemulsion-based clove oil enhances its toxicity on malignant breast cancer and cervical cancer cells. Pharmacia 68(4): 779-787. https://doi.org/10.3897/pharmacia.68.e68291
Figure 2 Cell viability of HeLa and MCF-7 cells after 24h of incubation with clove oil-based NE at various concentrations. Data are expressed as mean ± SE (n = 3). Asterisks denote statistical significance (***p < 0.001 considered as very highly significant, **0.001 ≤ p < 0.01 considered as highly significant, and *0.01 ≤ p < 0.05 considered as significant).
Figure 3 from: AlMotwaa SM (2021) Coupling Ifosfamide to nanoemulsion-based clove oil enhances its toxicity on malignant breast cancer and cervical cancer cells. Pharmacia 68(4): 779-787. https://doi.org/10.3897/pharmacia.68.e68291
Figure 3 Photomicrographs of cellular morphologies at IC50 after 24 h incubation (n=3). The arrows colored brown, green, red, black, and dark red indicate membrane blebbing, cytoplasmic vesicles, enlarged nuclei, loss of membrane integrity, and extracellular vesicles, respectively.
Figure 1 from: AlMotwaa SM (2021) Coupling Ifosfamide to nanoemulsion-based clove oil enhances its toxicity on malignant breast cancer and cervical cancer cells. Pharmacia 68(4): 779-787. https://doi.org/10.3897/pharmacia.68.e68291
Figure 1 Preparation and characterization of clove oil-based NE. A preparation of formulated NEsB, C Z-average diameter (n=3); D, E Zeta potential for n=3 using Zetasizer Malvern, UK). Asterisks denote statistical significance (**0.001 ≤ p < 0.01 considered as highly significant, and *0.01 ≤ p < 0.05 considered as significant).
Data for paper "MDM2 inhibitors, nutlin-3a and navtemadlin, retain efficacy in human and mouse cancer cells cultured in hypoxia"
<p>This repository contains data for manuscript with DOI: 10.1038/s41598-023-31484-0</p>
Annona squamosa Leaf Extract Inhibit Migration of Human Cervical Cancer Cells Through MMP-9 Expression
<p><strong>Table 1. Interpretation of suspected acetogenin compounds isolates</strong></p>
Fig. 2. Key HMBC, 1H– 1H in Hyperelodiones A-C, monoterpenoid polyprenylated acylphoroglucinols from Hypericum elodeoides, induce cancer cells apoptosis by targeting RXRα
Fig. 2. Key HMBC, 1H– 1H COSY and NOESY correlations of compounds 1–3.
Fig. 4 in Hyperelodiones A-C, monoterpenoid polyprenylated acylphoroglucinols from Hypericum elodeoides, induce cancer cells apoptosis by targeting RXRα
Fig. 4. Experimental ECD spectra of 1–3.
Fig. 1 in Hyperelodiones A-C, monoterpenoid polyprenylated acylphoroglucinols from Hypericum elodeoides, induce cancer cells apoptosis by targeting RXRα
Fig. 1. Structure of compounds 1–3.
Fig. 3 in Hyperelodiones A-C, monoterpenoid polyprenylated acylphoroglucinols from Hypericum elodeoides, induce cancer cells apoptosis by targeting RXRα
Fig. 3. Calculated and experimental ECD spectra of 1 and two tautomers.
Fig. 1 in Indole alkaloids from the leaves of Ravenia spectabilis engl. with activity against pancreatic cancer cell line
Fig. 1. Structures of alkaloids isolated from R. spectabilis Engl.
Fig. 2. NOESY correlations for compound 1 and HMBC correlations for compound 2 in Indole alkaloids from the leaves of Ravenia spectabilis engl. with activity against pancreatic cancer cell line
Fig. 2. NOESY correlations for compound 1 and HMBC correlations for compound 2.
Fig. 2. Key 1H–1H in Twelve undescribed derivatives of ganoderic acid isolated from Ganoderma luteomarginatum and their cytotoxicity against three human cancer cell lines
Fig. 2. Key 1H–1H COSY and HMBC correlations of 1–12.
Fig. 3 in Twelve undescribed derivatives of ganoderic acid isolated from Ganoderma luteomarginatum and their cytotoxicity against three human cancer cell lines
Fig. 3. Key NOESY correlations of 1–12.
Fig. 1 in Twelve undescribed derivatives of ganoderic acid isolated from Ganoderma luteomarginatum and their cytotoxicity against three human cancer cell lines
Fig. 1. Structures of compounds 1–12.
Fig. 4 in Panduratins Q-Y, dimeric metabolites from Boesenbergia rotunda and their antiausterity activities against the PANC-1 human pancreatic cancer cell line
Fig. 4. Electronic circular dichroism (ECD) spectra of 1 6, and 9 in EtOH.
Fig. 3 in Panduratins Q-Y, dimeric metabolites from Boesenbergia rotunda and their antiausterity activities against the PANC-1 human pancreatic cancer cell line
Fig. 3. The key NOESY correlations of cyclohexenyl unit of 5 9.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.