Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
10,694
datasets available to search
ShareScore release 0.9.0
Dataset results
10,694 results for “carcinoma,”
Association of lymph node metastasis of hepatocellular carcinoma with the gut microbiota, bile acid metabolism, and MIP-1α
<p>Supplementary figures for the manuscript.</p>
Data from: Identification and validation of a novel immune-related signature associated with macrophages and CD8 T cell infiltration predicting overall survival for hepatocellular carcinoma
<p><b>Background:</b> Although the effects of macrophages and CD8 T cell infiltration on clinical outcomes have been widely reported, the association between immunity-associated gene with them for hepatocellular carcinoma (HCC) remains unclear.</p> <p><b>Materials and methods: </b>The ssGSEA served for quantifying the macrophages as well as CD8 T cell infiltration in the HCC samples obtained from TCGA database. Kaplan-Meier(KM) survival assay was used to determine the associations between macrophages and CD8 T cell infiltration with OS. LASSO Cox regressive method assisted in developing an immune gene signature as well as building a risk score. The performance was evaluated by the time-dependent ROC together with the KM survival analysis. The ICGC database were adopted for external verification. CIBERSORT was applied to the correlation analysis on the immune-related signature and the immunocyte infiltration. GSEA were employed exploring the underlying molecular mechanisms.</p> <p><b>Results:</b> Increased CD8+ T cell infiltration was associated with longer OS, whereas a greater infiltration of macrophages was related to shorter OS. There were 398 differential expression genes (DEGs) between the high- and low infiltration groups with the "edgeR" package. A prognostic signature consisted of 10 immune genes was built in TCGA and examined in ICGC. The uniform cutoff (0.927) was adopted for separating sufferers into the high-risk(HR) and low-risk(LR) groups. The ROC curves revealed that the AUC data for this signature predicting 1,2,3,4 and 5 year were all above 0.7 in both TCGA and ICGC cohort and patients in the HR<sub> </sub>group exhibited evidently weaker prognostic results compared with the LR group. The HR<sub> </sub>group presented evidently greater Tregs and Macrophage M0 relative to the LR group, whereas the LR group saw the enrichment of CD8 T cells.</p> <p><b>Conclusion:</b> The immune signature associated with macrophages as well as CD8 T cell infiltration has reliable prognostic and predictive value for HCC patients.</p>
Endometrium Carcinoma Pipelle biopsies
<p>The dataset consists of n=91 digital pathology whole-slide images (WSI) of endometrium carcinoma Pipelle biopsies, stained with hematoxylin and eosin (H&E) at Radboud University Medical Centers, Nijmegen (The Netherlands).</p> <p>The WSIs were scanned with a 3DHistech P1000 scanners at 0.25 um/px spacing, originally stored in MRXS file format. However, the WSIs made available here have been converted to TIFF format with a maximum spacing of 0.5 um/px. This was done to make slides broadly accessible (since MRXS files are sometimes not compatible with some digital pathology viewers or APIs). In order to fit into the Zenodo requirements, the 91 slides are compressed into a .rar file.</p> <p>Together with the data, we have released a web-based evaluation platform via the <a href="https://grand-challenge.org/">grand-challenge.org</a> platform, which can be found at this link: <a href="https://endo-aid.grand-challenge.org/">https://endo-aid.grand-challenge.org/</a>. In this way, researchers can download the WSI from Zenodo, process them with their algorithm to predict a single grading score for each slide, compile the predictions as indicated on the grand-challenge.org page, and submit them, to compare the results with the opinion of a panel of fifteen pathologists.</p> <p>The data is released under CC BY-NC 4.0 license</p>
Nomogram Built Based on Machine Learning to Predict Recurrence in Early-stage Hepatocellular Carcinoma Patients Treated with Ablation
Open the record for dataset details and reuse information.
A Study of Lomvastomig (RO7121661) and Tobemstomig (RO7247669) Compared With Nivolumab in Participants With Advanced or Metastatic Squamous Cell Carcinoma of the Esophagus
ClinicalTrials.gov study NCT04785820. IPD Sharing: YES. Countries: 18. Publications: 0.
Study of Dalantercept in Patients With Squamous Cell Carcinoma of the Head and Neck
ClinicalTrials.gov study NCT01458392. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Low Level Laser Therapy for Radiation Induced Dermatitis in H & N Squamous Cell Carcinoma
ClinicalTrials.gov study NCT02384434. IPD Sharing: NO. Countries: 1. Publications: 0.
A Phase II Clinical Study of Treprilimab in the Treatment of Recurrent Nasopharyngeal Carcinoma After Re-irradiation
ClinicalTrials.gov study NCT04534855. IPD Sharing: YES. Countries: 0. Publications: 4.
Pre-Incisional Ketorolac for Patients Undergoing Surgery for Non-Small Cell Lung Cancer and Renal Cell Carcinoma
ClinicalTrials.gov study NCT04495894. IPD Sharing: NO. Countries: 1. Publications: 0.
Study of Vitespen (HSPPC-96, Oncophage ®) for Immune Response Assessment in Participants With Resectable Renal Cell Carcinoma at Intermediate Risk of Recurrence
ClinicalTrials.gov study NCT01147536. IPD Sharing: Not stated. Countries: 2. Publications: 0.
Study of Cabozantinib as Monotherapy or in Combination With Nivolumab in Patients With Advanced or Metastatic Renal Cell Carcinoma Under Real-life Clinical Setting in 1st Line Treatment.
ClinicalTrials.gov study NCT03647878. IPD Sharing: YES. Countries: 2. Publications: 0.
Alternative Schedule Sunitinib in Metastatic Renal Cell Carcinoma: Cardiopulmonary Exercise Testing
ClinicalTrials.gov study NCT03109015. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Doxorubicin-eluting LC Bead M1 for Patients With Hepatocellular Carcinoma
ClinicalTrials.gov study NCT02007954. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Dasatinib In Combination With Weekly Paclitaxel For Patients With Metastatic Breast Carcinoma CA 180 194
ClinicalTrials.gov study NCT00820170. IPD Sharing: Not stated. Countries: 1. Publications: 0.
CTLA-4 /PD-L1 Blockade Following Transarterial Chemoembolization (DEB-TACE) in Patients With Intermediate Stage of HCC (Hepatocellular Carcinoma) Using Durvalumab and Tremelimumab
ClinicalTrials.gov study NCT03638141. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
A Safety and Efficacy Study of CC-122 in Combination With Nivolumab in Subjects With Unresectable Hepatocellular Carcinoma (HCC)
ClinicalTrials.gov study NCT02859324. IPD Sharing: Not stated. Countries: 4. Publications: 0.
Comparison of Immediate and Delayed Adjuvant Chemotherapy in Treating Patients Who Have Undergone a Radical Cystectomy for Stage III or Stage IV Transitional Cell Carcinoma of the Bladder Urothelium
ClinicalTrials.gov study NCT00028756. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Hepatocellular Carcinoma Treated With Iodine-125 Implantation
ClinicalTrials.gov study NCT01717729. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Non-Contrast Perfusion Using Arterial Spin Labeled MR Imaging for Assessment of Therapy Response in Metastatic Renal Cell Carcinoma
ClinicalTrials.gov study NCT04831138. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Durvalumab (MEDI4736) and Tremelimumab for Hepatocellular Carcinoma in Patients Listed for a Liver Transplant
ClinicalTrials.gov study NCT05027425. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.