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14,866 results for “cancer cell”
Fig. 1 in Panduratins Q-Y, dimeric metabolites from Boesenbergia rotunda and their antiausterity activities against the PANC-1 human pancreatic cancer cell line
Fig. 1. Structures of isolated compounds from B. rotunda.
Fig. 8 in Diterpenoids from Euphorbia royleana reverse P-glycoprotein-mediated multidrug resistance in cancer cells
Fig. 8. Effects of 15 on the expression of P-gp.
Fig. 3 in Diterpenoids from Euphorbia royleana reverse P-glycoprotein-mediated multidrug resistance in cancer cells
Fig. 3. Key NOESY correlations () of compounds 1, 2, 4, 5, 6, and 8.
Fig. 1 in Diterpenoids from Euphorbia royleana reverse P-glycoprotein-mediated multidrug resistance in cancer cells
Fig. 1. The structures of compounds 1–30 and 8a.
Fig. 4. Single-crystal X in Diterpenoids from Euphorbia royleana reverse P-glycoprotein-mediated multidrug resistance in cancer cells
Fig. 4. Single-crystal X-ray structures of 1, 6, 7, and 8a.
Fig. 1 in Triterpenoids from Liquidambar Fructus induced cell apoptosis via a PI3KAKT related signal pathway in SMMC7721 cancer cells
Fig. 1. Chemical structures of 1–28.
Fig. 2 in Triterpenoids from Liquidambar Fructus induced cell apoptosis via a PI3KAKT related signal pathway in SMMC7721 cancer cells
Fig. 2. Key correlations in the HMBC spectra of compounds 1, 2 and 3.
Fig. 6 in Triterpenoids from Liquidambar Fructus induced cell apoptosis via a PI3KAKT related signal pathway in SMMC7721 cancer cells
Fig. 6. Effect of compounds 5, 7 and 8 on SMMC7721 cell cycle progression. *P <0.05 vs control.
Fig. 4. X-ray crystallographic data for 1 in Triterpenoids from Liquidambar Fructus induced cell apoptosis via a PI3KAKT related signal pathway in SMMC7721 cancer cells
Fig. 4. X-ray crystallographic data for 1.
Fig. 3 in Triterpenoids from Liquidambar Fructus induced cell apoptosis via a PI3KAKT related signal pathway in SMMC7721 cancer cells
Fig. 3. Selected NOE correlations of compounds 1, 2 and 3.
Dataset #1 related to article "NaCl enhances CD8+ T-cell effector functions in cancer immunotherapy"
<p><span>CD8<sup>+</sup> T cells control tumors but inevitably become dysfunctional. Ionic metabolism is emerging as a regulator of CD8<sup>+</sup> T cells in anti-tumor immunity. We show that sodium chloride (NaCl) counteracts T-cell dysfunction to promote cancer regression. NaCl supplementation during CD8<sup>+</sup> T-cell culture induced potent effector differentiation, IFN-</span><span>g</span><span> production and cytotoxicity while maintaining gene networks responsible for stem-like plasticity. Accordingly, adoptive transfer of tumor-specific T cells resulted in superior anti-tumor immunity in a humanized model. In mice, high-salt diet reduced growth of experimental tumors in a CD8<sup>+</sup> T cell-dependent manner, by inhibiting terminal differentiation, and by enhancing the effector potency of CD8<sup>+</sup> T cells. Mechanistically, NaCl enhanced glutamine consumption that was critical for transcriptional, epigenetic and functional reprogramming. In humans, CD8<sup>+</sup> T cells undergoing antigen recognition in tumors and predicting favorable response to checkpoint blockade immunotherapy resembled those induced by NaCl. Thus, NaCl metabolism is a major regulator of CD8<sup>+</sup> T-cell effector function, with potential translation in cancer immunotherapy.</span></p>
Lung-MAP: Durvalumab as Second-Line Therapy in Treating Patients With Recurrent Stage IV Squamous Cell Lung Cancer and No Matching Biomarkers
ClinicalTrials.gov study NCT02766335. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Study Comparing Two Different Chemotherapy Types in Chinese Patients With Advanced Non Small Cell Lung Cancer
ClinicalTrials.gov study NCT01005680. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Neoadjuvant or Adjuvant Chemotherapy in Patients With Operable Non-small-cell Lung Cancer
ClinicalTrials.gov study NCT00913705. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Study Evaluating the Addition of Fulvestrant to Erlotinib in Stage IIIB/IV Non-Small Cell Lung Cancer
ClinicalTrials.gov study NCT00592007. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Azacitidine and Entinostat in Treating Patients With Stage I Non-Small Cell Lung Cancer That Has Been Removed By Surgery
ClinicalTrials.gov study NCT01207726. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Pre-Incisional Ketorolac for Patients Undergoing Surgery for Non-Small Cell Lung Cancer and Renal Cell Carcinoma
ClinicalTrials.gov study NCT04495894. IPD Sharing: NO. Countries: 1. Publications: 0.
Abscopal Effect for Metastatic Small Cell Lung Cancer
ClinicalTrials.gov study NCT02542137. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Capecitabine and Lapatinib Ditosylate in Treating Patients With Squamous Cell Cancer of the Head and Neck
ClinicalTrials.gov study NCT01044433. IPD Sharing: Not stated. Countries: 1. Publications: 0.
R-(-)-Gossypol Acetic Acid in Treating Patients With Recurrent Extensive-Stage Small Cell Lung Cancer
ClinicalTrials.gov study NCT00773955. IPD Sharing: Not stated. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.