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2,143 results for “All Spinal Cord”
Per2 mediates neuroinflammation-driven depression after spinal cord injury and serves as a biomarker-target
GEO Series GSE297887. Mus musculus. 7 samples. Type: Expression profiling by high throughput sequencing.
Raw data to "Pro-resolving lipid mediator lipoxin A4 attenuates neuro-inflammation by modulating T cell responses and modifies the spinal cord lipidome"
<p>Background: Impairments in timely resolving inflammation is now considered a key hallmark of chronic inflammation and the development of neurodegenerative diseases such as multiple sclerosis (MS). Lipoxins are among the mediators of resolution of inflammation and their role in MS is scarce.</p> <p>Results: We treated experimental autoimmune encephalomyelitis (EAE) mice, the experimental model of MS, with lipoxin A4 (LXA4) daily and intraperitoneally either mimicking a prophylactic treatment (from day 8 post immunization, namely before the acute phase) or a therapeutic treatment (from day 21 post immunization, namely at the peak of disease) and both until the end of the experiment with 100 ng/mouse of LXA4 or vehicle. When given in a prophylactic setting, LXA4 treatment significantly ameliorated EAE clinical scores (Fig.1A), counteracted the reduction in the body weight (Fig.1B) and reduced disease severity (Fig.1C) compared to EAE vehicle-treated mice. Moreover, histological examination of the spinal cord at the peak of the disease revealed a profound reduction of CD45+ inflammatory cells in LXA4-treated as compared to vehicle-treated EAE mice (Fig. 1D). However, LXA4 treatment in a therapeutic setting, slightly reduced EAE clinical scores (Fig. 1E) and did not modify body weight compared to the EAE-vehicle treaded mice (Fig.1F).</p> <p>Conclusions: These data suggest that boosting resolution of inflammation in vivo can halt clinical symptoms in experimental MS and eventually reduce or halt disease progression.</p>
dataset related to article "Sporadic and von Hippel–Lindau Related Hemangioblastomas of Brain and Spinal Cord: Multimodal Imaging for Intraoperative Strategy"
<p>Datasheet containing clinicla anonimyzed information on patients involved in study at title</p>
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.