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1,870 results for “Adipose tissue”
Correlation analysis of epicardial adipose tissue and ventricular myocardial strain in Chinese amateur marathoners using cardiac magnetic resonance
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Data from: Estradiol-mediated improvements in adipose tissue insulin sensitivity are related to the balance of adipose tissue estrogen receptor α and β in postmenopausal women
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Magnetic resonance imaging reveals human brown adipose tissue is rapidly activated in response to cold
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Data from: Immune checkpoint protein VSIG4 as a biomarker of aging in Murine adipose tissue
<p>Adipose tissue is recognized as a major source of systemic inflammation with age, driving age-related tissue dysfunction and pathogenesis. Macrophages (Mϕ) are central to these changes yet adipose tissue Mφ (ATMs) from aged mice remain poorly characterized. To identify biomarkers underlying changes in aged adipose tissue, we performed an unbiased RNA-seq analysis of ATMs from young (10-week old) and healthy aged (80-week old) mice. One of the genes identified, V-set immunoglobulin-domain-containing 4 (VSIG4/CRIg), encodes a Mφassociated complement receptor and B7 family-related immune checkpoint protein. Here, we demonstrate that Vsig4 expression is highly upregulated with age in perigonadal white adipose tissue (gWAT) in two mouse strains (inbred C57BL/6J and outbred NIH Swiss) independent of gender. The accumulation of VSIG4 was mainly associated with a 4-fold increase in the proportion of VSIG4+ ATMs (13% to 52%). In a longitudinal study, VSIG4 expression in gWAT showed a strong correlation with age within a cohort of male and female mice and correlated strongly with physiological frailty index (PFI, a multi-parameter assessment of health) in male mice. Our results indicate that VSIG4 is a novel biomarker of aged murine ATMs. VSIG4 expression was also found to be elevated in other aging tissues (e.g., thymus), and was strongly induced in tumor-adjacent stroma in cases of spontaneous and xenograft lung cancer models. VSIG4 expression was recently associated with cancer and several inflammatory diseases with diagnostic and prognostic potential in both mice and humans. Further investigation is required to determine whether VSIG4-positive Mϕ contribute to immunosenescence and/or systemic age-related deficits.</p>
Exposure to low doses of Dechlorane Plus promotes adipose tissue dysfunction and glucose intolerance in mice
<p>The prevalence of type 2 diabetes (T2D) continues to increase worldwide. It is well established that genetic susceptibility, obesity, overnutrition and a sedentary life style are risk factors for the development of T2D. However, more recently, studies have also proposed links between exposure to endocrine-disrupting chemicals (EDCs) and altered glucose metabolism. Human exposure to environmental pollutants suspected to have endocrine disruptor activity is ubiquitous. One such chemical is Dechlorane Plus, a flame retardant, that is now detected in humans and the environment. Here we show that exposure of mice to low, environmentally relevant doses of Dechlorane Plus (DP), promoted glucose intolerance in mice fed high fat diet independent of weight gain. Further, DP had pronounced effects on the adipose tissue, where it induced the development of hypertrophied white adipose tissue (WAT), and increased serum levels of resistin, leptin, and plasminogen activator inhibitor-1. Further, DP exposure induced "whitening" of brown adipose tissue (BAT), and reduced BAT <i>uncoupling protein 1</i> expression. Importantly, some of these effects occurred even when the mice were fed regular, low fat, diet. Finally, WAT adipogenic markers were reduced with DP treatment in the WAT. We also show that, DP directly inhibited insulin signalling in murine adipocytes and human primary subcutaneous adipocytes <i>in vitro</i>. Taken together, our results show that the exposure to low and environmentally relevant levels of DP may contribute to the development of T2D.</p>
Data from: Sympathetic nervous system activity and anti-lipolytic response to IV-glucose load in subcutaneous adipose tissue of obese and obese type 2 diabetic subjects
The study aim was to investigate the effect of endogenous insulin release on lipolysis in subcutaneous adipose tissue after adrenergic stimulation in obese subjects diagnosed with type 2 diabetes (T2D). In 14 obese female T2D subjects, or 14 obese non-T2D controls, glycerol concentration was measured in response to the α1,2,ß-agonist norepinephrine, the α1-agonist norfenefrine and the ß2-agonist terbutaline (each 10-4 M), using the microdialysis technique. After 60 minutes of stimulation, an intravenous glucose load (0.5 g/kg lean body mass) was given. Local blood flow was monitored by means of the ethanol technique. Norepinephrine and norfenefrine induced a four and three fold rise in glycerol dialysate concentration (p<0.001, each), with a similar pattern in adipose tissue. Following agonist stimulation and glucose infusion, endogenous insulin release inhibited lipolysis in the presence of norepinephrine, which was more rapid and pronounced in healthy obese controls than in T2D subjects (p=0.024 obese vs T2D subjects). Insulin-induced inhibition of lipolysis in the presence of norfenefrine was similar in all study participants. In the presence of terbutaline the lipolysis rate increased two fold until the effect of endogenous insulin (p<0.001). A similar insulin-induced decrease in lipolysis was observed for each of the norfenefrine groups and the terbutaline groups, respectively. Adipose tissue blood flow remained unchanged after the iv-glucose load. Both norepinephrine and norfenefrine diminished blood flow slightly, but insulin reversed this response (p<0.001 over the entire time). Terbutaline alone and terbutaline plus increased endogenous insulin augmented local blood flow (p<0.001 over the entire time). In conclusion, a difference in insulin-induced inhibition of lipolysis was observed in obese T2D subjects compared to obese healthy controls following modulation of sympathetic nervous system activity and is assumed to be due to ß1-adrenoceptor mediated stimulation by norepinephrine.
Ex vivo T2* and DTI parameters of brown and white adipose tissues in cold-exposed mice
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Mechanical behavior of silicone membranes for adipose tissue synthesis in clinical and theatrical prosthesis
<p>Supplimentary data and figures</p>
Identifying GPCRs involved in adipose tissue function using the innovative RNA-seq database FATTLAS
<p>G protein-coupled receptors (GPCRs) modulate the function of adipose tissue (AT) in general and of adipocytes, specifically. Although it is well-established that GPCRs are widely expressed in AT, their repertoire as well as their regulation and function in (patho)physiological conditions (e.g., obesity) is not fully resolved. Here, we established FATTLAS, an interactive public database, for improved access and analysis of RNA-seq data of mouse and human AT. After extracting the GPCRome of non-obese and obese individuals, highly expressed and regulated GPCRs were identified. Exemplarily, we describe four receptors (MRGPRF, GPR146, FZD5, PTGER2) and analyzed their functions in a (pre)adipocyte cell model. Besides all receptors being involved in adipogenesis, MRGPRF is essential for adipocyte viability and regulates cAMP levels, while GPR146 modulates adipocyte lipolysis via constitutive activation of Gi proteins. Taken together, by implementing and using FATTLAS we describe four hitherto unrecognized GPCRs associated with AT function and adipogenesis.</p>
Brown Adipose Tissue as a Therapeutic for the Metabolic and Cardiac Dysfunction With Senescence (BATSR)
ClinicalTrials.gov study NCT04168580. IPD Sharing: NO. Countries: 1. Publications: 0.
Treatment of Subcutaneous Adipose Tissue in the Thighs Using High Intensity Focused Ultrasound
ClinicalTrials.gov study NCT01823653. IPD Sharing: Not stated. Countries: 2. Publications: 0.
The Effect of Micro Fragmented Adipose Tissue (MFAT) on Knee Osteoarthritis
ClinicalTrials.gov study NCT03467919. IPD Sharing: NO. Countries: 1. Publications: 0.
Comparing the Efficacy of a Dual-Frequency LLLT Device With a Sham Device as a Therapy for Adipose Tissue Loss
ClinicalTrials.gov study NCT03811093. IPD Sharing: NO. Countries: 1. Publications: 0.
Dapagliflozin in Reducing Epicardial Adipose Tissue in Heart Failure with Preserved Ejection Fraction
ClinicalTrials.gov study NCT06510270. IPD Sharing: UNDECIDED. Countries: 0. Publications: 0.
Celecoxib Inhibition of Aromatase Expression and Inflammation in Adipose Tissue of Obese Postmenopausal Women
ClinicalTrials.gov study NCT01901679. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Exercise Regulation of Human Adipose Tissue
ClinicalTrials.gov study NCT03133156. IPD Sharing: NO. Countries: 1. Publications: 0.
The Impact of the Distribution of Adipose Tissue on the Occurrence of Metabolic Disorders and the Level of Cardiopulmonary Fitness
ClinicalTrials.gov study NCT05612282. IPD Sharing: NO. Countries: 0. Publications: 12.
GLP-1 Therapy: The Role of IL-6 Signaling and Adipose Tissue Remodeling in Metabolic Response
ClinicalTrials.gov study NCT04387201. IPD Sharing: YES. Countries: 1. Publications: 0.
Evaluation of the Treatment of Adipose Tissue With Liposonix System (Model 2) Using a New Treatment Method
ClinicalTrials.gov study NCT01853397. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Does Cold Provocation Increase Brown Adipose Tissue Volume?
ClinicalTrials.gov study NCT01797328. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.