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490 results for “DNA integrity”
Supplementary material 4 from: Colgan DJ, Ahyong ST, Mardon K, Brereton IM (2021) Rare specimen identification in an un-integrated taxonomy: implications of DNA sequences from a Taiwanese Philine (Mollusca, Philinidae). ZooKeys 1060: 93-110. https://doi.org/10.3897/zookeys.1060.28809
Figure S3. Phylogenetic relationships of C.559479 based on Maximum Likelihood analysis of the histone H3 dataset.
Supplementary material 3 from: Colgan DJ, Ahyong ST, Mardon K, Brereton IM (2021) Rare specimen identification in an un-integrated taxonomy: implications of DNA sequences from a Taiwanese Philine (Mollusca, Philinidae). ZooKeys 1060: 93-110. https://doi.org/10.3897/zookeys.1060.28809
Figure S2. Phylogenetic relationships of C.559479 based on maximum likelihood analysis of the D1 28S rRNA dataset
Figure 4 in Integrative taxonomy of eared nightjars (Aves: Lyncornis) underscores the complementarity of morphology, vocalizations and DNA evidence
Figure 4. Sonograms of territorial songs of Lyncornis. A, Lyncornis macrotis bourdilloni, Kerala, India, B. King. B, Lyncornis macrotis cerviniceps, Thailand, J. C. Roché (BLSA 42510). C, Lyncornis macrotis jacobsoni, Simeulue Island, F. Verbelen. D, Lyncornis temminckii, Johore, Malaysia, T. C. White (BLSA 6414). E, L. temminckii, Way Kambas, Sumatra, A. B. van den Berg (ML 70527). F, Lyncornis macrotis macrotis, Mindanao, A. Greensmith (BLSA 34287). G, Lyncornis macrotis macropterus, Tangkoko Batuangus, Sulawesi, G. Sangster (GS 1841).
Figure 8 in Integrative taxonomy of eared nightjars (Aves: Lyncornis) underscores the complementarity of morphology, vocalizations and DNA evidence
Figure 8. Integrative taxonomy of Lyncornis nightjars, illustrating contrasting sensitivities of datasets and the failure of each dataset to recover all five species.
Figure 3 in Integrative taxonomy of eared nightjars (Aves: Lyncornis) underscores the complementarity of morphology, vocalizations and DNA evidence
Figure 3. Maximum likelihood tree of cytochrome b sequences of the genus Lyncornis and various outgroups. Bootstrap proportions (> 70%) and posterior probabilities (> 0.8) are indicated above and below branches, respectively.
Figure 1 in Integrative taxonomy of eared nightjars (Aves: Lyncornis) underscores the complementarity of morphology, vocalizations and DNA evidence
Figure 1. Map showing range of currently recognized taxa in the Lyncornis macrotis complex. Taxonomy follows Cleere (1998).
Figure 7 in Integrative taxonomy of eared nightjars (Aves: Lyncornis) underscores the complementarity of morphology, vocalizations and DNA evidence
Figure 7. Upper tail of four taxa in the Lyncornis macrotis complex, illustrating differences in pattern and coloration. Note the marked differences in pattern and coloration between L. m. cerviniceps and L. m. jacobsoni. G. Sangster/©Naturalis Biodiversity Center, Leiden.
Figure 2 in Integrative taxonomy of eared nightjars (Aves: Lyncornis) underscores the complementarity of morphology, vocalizations and DNA evidence
Figure 2. Measurement of acoustic variables. For definitions of acoustic variables, see 'Measurements of acoustic characters'.
ATM-ESCO2-SMC3 axis promotes 53BP1 recruitment in response to DNA damage and safeguards genome integrity by stabilizing cohesin complex
<p>53BP1 is primarily known as a key regulator in DNA double-strand break (DSB) repair. However, the mechanism of DSB-triggered cohesin modification-modulated chromatin structure on the recruitment of 53BP1 remains largely elusive. Here we identified acetyltransferase ESCO2 as a regulator for DSB-induced cohesin-dependent chromatin structure dynamics, which promotes 53BP1 recruitment. Mechanistically, in response to DNA damage, ATM phosphorylates ESCO2 S196 and T233. MDC1 recognizes phosphorylated ESCO2 and recruits ESCO2 to DSB sites. ESCO2-mediated acetylation of SMC3 stabilizes cohesin complex conformation and regulates the chromatin structure at DSB breaks, which is essential for the recruitment of 53BP1 and the formation of 53BP1 microdomains. Furthermore, depletion of ESCO2 in both colorectal cancer cells and xenografted nude mice sensitizes cancer cells to chemotherapeutic drugs. Collectively, our results reveal a molecular mechanism for the ATM-ESCO2-SMC3 axis in DSB repair and genome integrity maintenance with a vital role in chemotherapy response in colorectal cancer.</p>
ATM-ESCO2-SMC3 axis promotes 53BP1 recruitment in response to DNA damage and safeguards genome integrity by stabilizing cohesin complex
<p>53BP1 is primarily known as a key regulator in DNA double-strand break (DSB) repair. However, the mechanism of DSB-triggered cohesin modification-modulated chromatin structure on the recruitment of 53BP1 remains largely elusive. Here we identified acetyltransferase ESCO2 as a regulator for DSB-induced cohesin-dependent chromatin structure dynamics, which promotes 53BP1 recruitment. Mechanistically, in response to DNA damage, ATM phosphorylates ESCO2 S196 and T233. MDC1 recognizes phosphorylated ESCO2 and recruits ESCO2 to DSB sites. ESCO2-mediated acetylation of SMC3 stabilizes cohesin complex conformation and regulates the chromatin structure at DSB breaks, which is essential for the recruitment of 53BP1 and the formation of 53BP1 microdomains. Furthermore, depletion of ESCO2 in both colorectal cancer cells and xenografted nude mice sensitizes cancer cells to chemotherapeutic drugs. Collectively, our results reveal a molecular mechanism for the ATM-ESCO2-SMC3 axis in DSB repair and genome integrity maintenance with a vital role in chemotherapy response in colorectal cancer.</p>
Impact of Sperm DNA Integrity on Artificial Reproductive Treatment (ART)
ClinicalTrials.gov study NCT00875095. IPD Sharing: Not stated. Countries: 1. Publications: 7.
Predicting Non-small Cell Lung Cancer (NSCLC) Lymph Node Metastasis: Integrating Circulating Tumor DNA (ctDNA) Mutation/ Methylation Profiling With Positron Emission Tomography-computed Tomography (PE
ClinicalTrials.gov study NCT06358222. IPD Sharing: NO. Countries: 1. Publications: 6.
Data from: Integrative taxonomy at work: DNA barcoding of taeniids harbored by wild and domestic cats
Open the record for dataset details and reuse information.
Data from: Integrating three comprehensive datasets shows that mitochondrial DNA variation is linked to species traits and paleogeographic events in European butterflies.
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Supplementary information for integrating sequence capture and restriction-site associated DNA sequencing to resolve recent radiations of Pelagic seabirds
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Integrative biodiversity inventories: characterizing lichen-forming fungal diversity in Glen Canyon National Recreation Area using DNA barcoding and vouchered specimens
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Fig. 55. Maximum likelihood tree inferred from ITS2 in Description of a new species of Loxosceles Heineken & Lowe (Araneae, Sicariidae) recluse spiders from Hidalgo, Mexico, under integrative taxonomy: morphological and DNA barcoding data (CO1 + ITS2)
Fig. 55. Maximum likelihood tree inferred from ITS2 gene of species of Loxosceles Heineken & Lowe, 1832 from Mexico. Colors of branches and bars indicate different species. Numbers above bars represent the delimitation methods: 1 = morphology (M); 2 = neighbor joining (NJ); 3–4 = ABGD with initial partitions (IP); 5–7 = ABGD with recursive partitions (RP); 8 = GMYC yule analysis; 9 = GMYC coalescent analysis; 10 = bPTP with ML; 11 = bPTP with IB. Numbers below bars represent species recovered for each delimitation method. Red numbers on branches correspond to Bayesian posterior probabilities, black numbers are bootstrap support values from the ML analysis.
Figs 26–29 in Description of a new species of Loxosceles Heineken & Lowe (Araneae, Sicariidae) recluse spiders from Hidalgo, Mexico, under integrative taxonomy: morphological and DNA barcoding data (CO1 + ITS2)
Figs 26–29. Loxosceles tolantongo sp. nov. 26–27. Caparace of ♂ holotype (CNAN-T01317) and ♀ paratype (CNAN-T01321), respectively. 28–29. ♀ paratype (CNAN-T01321). 28. Seminal receptacles. 29. Genital area, ventral view. Scale bars: 26–27 = 1 mm; 28 = 0.2 mm; 29 = 0.5 mm.
Fig. 52 in Description of a new species of Loxosceles Heineken & Lowe (Araneae, Sicariidae) recluse spiders from Hidalgo, Mexico, under integrative taxonomy: morphological and DNA barcoding data (CO1 + ITS2)
Fig. 52. Neighbor joining tree constructed from CO1 data of nine species of Loxosceles Heineken & Lowe, 1832 from Mexico. Colors of branches indicate different species. Numbers on nodes are bootstrap support values. Red circle at node represents Loxosceles tolantongo sp. nov.
Figs 10–15 in Description of a new species of Loxosceles Heineken & Lowe (Araneae, Sicariidae) recluse spiders from Hidalgo, Mexico, under integrative taxonomy: morphological and DNA barcoding data (CO1 + ITS2)
Figs 10–15. Habitat and microhabitat of Loxosceles tolantongo sp. nov. 10–11. Xerophytic forest from the type locality: Tourist Center Grutas de Tolantongo, Municipality of Cardonal, Hidalgo, Mexico. 12–15. Microhabitat situated 500 m west of entrance No. 5 to the Tourist Center Grutas de Tolantongo, Municipality of Cardonal, Hidalgo, Mexico (arrows indicate the microhabitat where the specimens can be found: under big rocks and inside of rotten and dry agave plants). Photos 10, 12–14 by Claudia Isabel Navarro-Rodríguez (2018); photos 11, 15 by Alejandro Valdez-Mondragón (2018).
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.