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Sequence analysis of tumors from immunosuppressed patients
<pre><strong>Rationale</strong>: This repository contains the intermediate data produced in <a href="https://www.nature.com/articles/s41598-019-56240-1">Passaro et al 2019</a>. <strong>Background</strong>: The metagenomic investigations have unveiled the tight relationship between microbes, viruses and human health. In this scenario potentially oncogenic viruses may play a key role in promoting cancer development in immunosuppressed subjects. T he raw data mentioned in the paper are accessible in the *SRA* repository under the BioProject <strong><a href="https://www.ncbi.nlm.nih.gov/bioproject/PRJNA544407">PRJNA544407</a></strong>. <strong>Methods</strong>: A thoroughly description about the bioinformatic analysis performed in Passaro et al 2019 are accessible at <a href="https://github.com/bfosso/SDATA_bio_Desc">https://github.com/bfosso/SDATA_bio_Deschttps://github.com/bfosso/SDATA_bio_Desc</a>. </pre>
Fig. 2. Key 1H–1H in Discovery of Undescribed Monoterpenoid Polyprenylated Acylphloroglucinols with Immunosuppressive Activities from Hypericum longistylum
Fig. 2. Key 1H–1H COSY, HMBC and NOESY correlations of compounds 1 and 3.
Fig. 1 in Discovery of Undescribed Monoterpenoid Polyprenylated Acylphloroglucinols with Immunosuppressive Activities from Hypericum longistylum
Fig. 1. Chemical structures of compounds 1–7.
Fig. 1 in Immunosuppressive gentianellane-type sesterterpenoids from the traditional Uighur medicine Gentianella turkestanorum
Fig. 1. Chemical structures of compounds 1–12 from Gentianella turkestanorum.
Fig. 4. X in Immunosuppressive gentianellane-type sesterterpenoids from the traditional Uighur medicine Gentianella turkestanorum
Fig. 4. X-ray crystallographic structure of compound 4.
Fig. 2. Key 2D in (±)-hyperzewalsins A D, four pairs of nor-monocyclic polyprenylated acylphloroglucinols with immunosuppressive activity from hypericum przewalskii maxim
Fig. 2. Key 2D NMR correlations of compounds 1–5.
Fig. 7 in (±)-hyperzewalsins A D, four pairs of nor-monocyclic polyprenylated acylphloroglucinols with immunosuppressive activity from hypericum przewalskii maxim
Fig. 7. Experimental and calculated ECD spectra of compounds 1b, 2b, 3a, and 4a.
Fig. 9 in (±)-hyperzewalsins A D, four pairs of nor-monocyclic polyprenylated acylphloroglucinols with immunosuppressive activity from hypericum przewalskii maxim
Fig. 9. Plausible biogenetic pathway of compounds 1–7.
Fig. 6 in Piperazine-2,5-dione derivatives and an α-pyrone polyketide from Penicillium griseofulvum and their immunosuppression activity
Fig. 6. ECD spectra of compounds 2–4 and 6.
Fig. 8. 1H in Piperazine-2,5-dione derivatives and an α-pyrone polyketide from Penicillium griseofulvum and their immunosuppression activity
Fig. 8. 1H NMR Δδ values in ppm for the bis-S- and R-MTPA esters of 5 in S-R Methanol-d4.
Fig. 8 in (±)-hyperzewalsins A D, four pairs of nor-monocyclic polyprenylated acylphloroglucinols with immunosuppressive activity from hypericum przewalskii maxim
Fig. 8. Experimental ECD spectra of 5 and calculated ECD spectra of molecular models A and B.
Fig. 2. Key 1H–1H in Piperazine-2,5-dione derivatives and an α-pyrone polyketide from Penicillium griseofulvum and their immunosuppression activity
Fig. 2. Key 1H–1H COSY, HMBC, NOESY, and 1H–15N HMBC correlations of compound 1.
Fig. 1 in Piperazine-2,5-dione derivatives and an α-pyrone polyketide from Penicillium griseofulvum and their immunosuppression activity
Fig. 1. Chemical structures of compounds 1–9.
Fig. 2. Key 1 H– 1 H in Immunosuppressive gentianellane-type sesterterpenoids from the traditional Uighur medicine Gentianella turkestanorum
Fig. 2. Key 1 H– 1 H COSY and HMBC correlations of compounds 2–10 and 12.
Fig. 3 in Immunosuppressive gentianellane-type sesterterpenoids from the traditional Uighur medicine Gentianella turkestanorum
Fig. 3. Key ROESY correlations of compounds 2–10.
Fig. 6 in (±)-hyperzewalsins A D, four pairs of nor-monocyclic polyprenylated acylphloroglucinols with immunosuppressive activity from hypericum przewalskii maxim
Fig. 6. Experimental ECD spectra (in MeOH) of 1a/1b–4a/4b.
Fig. 1 in (±)-hyperzewalsins A D, four pairs of nor-monocyclic polyprenylated acylphloroglucinols with immunosuppressive activity from hypericum przewalskii maxim
Fig. 1. Chemical structures of compounds 1–7.
Fig. 3 in (±)-hyperzewalsins A D, four pairs of nor-monocyclic polyprenylated acylphloroglucinols with immunosuppressive activity from hypericum przewalskii maxim
Fig. 3. Configurational and conformational analysis of (5S*,13R*)-1.
Fig. 5. Proposed biosynthetic pathway for compounds 1–12 in Immunosuppressive gentianellane-type sesterterpenoids from the traditional Uighur medicine Gentianella turkestanorum
Fig. 5. Proposed biosynthetic pathway for compounds 1–12.
Fig. 2. Key 2D in Secoiridoids and triterpenoids from the traditional Tibetan medicine Gentiana veitchiorum and their immunosuppressive activity
Fig. 2. Key 2D NMR correlations of compounds 1, 2, 11 and 12.
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