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2,709 results for “Mouse Model”
Ocular graft vs host disease mouse model
<p>Ocular graft versus host disease (OGvHD) develops in nearly 50% of patients after allogeneic hematopoietic stem cell transplantation (HSCT) and frequently manifests as dry eye disease (DED). The aim of this study was to evaluate the efficacy of a single subconjunctival (SCJ) dose of adeno-associated virus (AAV) gene therapy encoding human leukocyte antigen G (HLA-G) isoforms 1 and 5 to induce ocular immune tolerance and inhibit development of clinical signs of OGvHD.</p>
Astrocytic Expression of Yes-Associated Protein (YAP) Regu-lates Retinal Neovascularization in a Mouse Model of Oxy-gen-Induced Retinopathy
<p>Original images used for each figure.</p>
Synthesis and preclinical evaluation of a novel fluorine-18 labeled small-molecule PET radiotracer for imaging of CXCR3 receptor in mouse models of atherosclerosis
<p>Background CXCR3 is a chemokine receptor and is expressed in innate and adaptive immune cells. It promotes<br> the recruitment of T-lymphocytes and other immune cells to the inflammatory site in response to the binding of cognate<br> chemokines. Upregulation of CXCR3 and its chemokines has been found during atherosclerotic lesion formation.<br> Therefore, detection of CXCR3 by positron emission tomography (PET) radiotracer can be a useful tool for detecting the development of atherosclerosis in a noninvasive manner. Herein, we report the synthesis, radiosynthesis, and characterization of a novel fluorine-18 (F-18, <sup>18</sup>F) labeled small-molecule radiotracer for the imaging of the CXCR3 receptor in mouse models of atherosclerosis.<br> Results The reference standard <strong>1</strong> and its precursor <strong>9</strong> were synthesized over 5 steps from starting materials in good to moderate yields. The measured K<sub>i</sub> values of CXCR3A and CXCR3B were 0.81 ± 0.02 nM and 0.31 ± 0.02 nM, respectively. [<sup>18</sup>F]<strong>1</strong> was prepared by a two-step radiosynthesis with a decay-corrected radiochemical yield of 13 ± 2%, radiochemical purity > 99%, and specific activity of 44.4 ± 3.7 GBq/μmol at the end of synthesis (n = 6). The baseline studies showed that [<sup>18</sup>F]<strong>1</strong> displayed high uptake in the atherosclerotic aorta and brown adipose tissue in Apolipoprotein E (ApoE) knockout (KO) mice fed with a high-fat diet over 12 weeks. The uptake of [<sup>18</sup>F]<strong>1</strong> in these regions was reduced significantly in self-blocking studies, demonstrating CXCR3 binding specificity. Contrary to this, no significant differences in uptake of [<sup>18</sup>F]<strong>1</strong> in the abdominal aorta of C57BL/6 control mice fed with a normal diet were observed in both baseline and blocking studies, indicating increased CXCR3 expression in atherosclerotic lesions. Immunohistochemistry studies demonstrated that [<sup>18</sup>F]<strong>1</strong>-positive regions were correlated with CXCR3 expression, but some<br> atherosclerotic plaques with significant size were not detected by [<sup>18</sup>F]<strong>1</strong>, and their CXCR3 expressions were minimal.<br> Conclusion [<sup>18</sup>F]<strong>1</strong> was synthesized with good radiochemical yield and high radiochemical purity. In PET imaging<br> studies, [<sup>18</sup>F]<strong>1</strong> displayed CXCR3-specific uptake in the atherosclerotic aorta in ApoE KO mice. [<sup>18</sup>F]<strong>1</strong> visualized CXCR3<br> expression in different regions in mice aligned with the tissue histology studies. Taken together, [<sup>18</sup>F]<strong>1</strong> is a potential<br> PET radiotracer for imaging CXCR3 in atherosclerosis.</p>
Data from: Low-dose proton radiation effects in a transgenic mouse model of Alzheimer's Disease - implications for space travel
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Data from: Characterization of leukemia-inducing genes using a proto-oncogene/homeobox gene retroviral human cDNA library in a mouse in vivo model
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Data from: Correlations of behavioral deficits with brain pathology assessed through longitudinal MRI and histopathology in the HDHQ150/Q150 mouse model of Huntington's disease
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Data from: Influence of full-length dystrophin on brain volumes in mouse models of Duchenne muscular dystrophy
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Data from: Escitalopram and NHT normalized stress-induced anhedonia and molecular neuroadaptations in a mouse model of depression
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Influence of amyloid pathology on retina and dLGN in 5xFAD mouse model
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Data from: Characterization of a transgenic mouse model exhibiting spontaneous lung adenocarcinomas with a metastatic phenotype
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Ocular graft vs host disease mouse model
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Data from: Metabolite profile of a mouse model of Charcot-Marie-Tooth type 2D neuropathy: implications for disease mechanisms and interventions
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Data from: Overexpression of Dyrk1A is implicated in several cognitive, electrophysiological and neuromorphological alterations found in a mouse model of Down syndrome
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Data from: A four-component model of the action potential in mouse detrusor smooth muscle cell
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A novel and accurate full-length HTT mouse model for Huntington’s disease
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Data from: Impaired hippocampal place cell dynamics in a mouse model of the 22q11.2 deletion
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Vitamin D modulates cortical transcriptome in an Mecp2 heterozygous Rett syndrome mouse model
GEO Series GSE180630. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
Tractable mouse TNBC models capture the heterogeneous tumor immune microenvironment and adaptation to PD-L1 blockade
GEO Series GSE290815. Mus musculus. 14 samples. Type: Expression profiling by high throughput sequencing.
Effect of the CSF1R inhibitor AZD7507 on a relapse mouse model of high-grade serous ovarian cancer
GEO Series GSE158812. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Decoding Dengue's Neurological Assault: Insights from Single-Cell CNS Analysis in a Mouse Model
GEO Series GSE252515. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.