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3,029 results for “Osteoarthritis”
Study to Evaluate the Efficacy, Safety, Tolerability and Pharmacokinetics of AZD1386 in Patients With Osteoarthritis (OA) of the Knee
ClinicalTrials.gov study NCT00878501. IPD Sharing: Not stated. Countries: 7. Publications: 1.
Assessment of cardiovascular risk factors in patients with Knee Osteoarthritis
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Panaxatriol exerts anti-senescence effects and alleviates osteoarthritis and cartilage repair fibrosis by targeting UFL1
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Adipose-derived leptin and complement factor D mediate osteoarthritis severity and pain
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Senescent preosteoclast secretome promotes metabolic syndrome-associated osteoarthritis through COX2-PGE2
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Molecular dynamics simulation files for: a molecular machine efficiently drives glycosaminoglycan assembly and secretion for osteoarthritis therapy
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Evaluation of articular cartilage with quantitative MRI in an equine model of post-traumatic osteoarthritis
<p>This dataset contains raw qMRI data and the corresponding calculated relaxation time maps, reference data and an example MATLAB script demonstrating how to access the data, comprising study:</p> <p><strong>Evaluation of articular cartilage with quantitative MRI in an equine model of post-traumatic osteoarthritis </strong></p> <p>Journal of Orthopaedic Research | DOI: https://doi.org/10.1002/jor.24780</p> <p>Kajabi Abdul Wahed*(1,2), Casula Victor(1,2), Sarin Jaakko K.(3,4), Ketola Juuso H.(1), Nykänen Olli(3), te Moller Nikae C.R.(5), Mancini Irina A.D.(5), Visser Jetze(6), Brommer Harold(5), van Weeren P. René(5), Malda Jos(5,6), Töyräs Juha(3,4,7), Nieminen Miika T.(1,2,8), Nissi Mikko J.*(1,3)</p> <ol> <li>Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland</li> <li>Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland </li> <li>Department of Applied Physics, University of Eastern Finland, Kuopio, Finland</li> <li>Diagnostic Imaging Center, Kuopio University Hospital, Kuopio, Finland</li> <li>Department of Equine Sciences, Faculty of Veterinary Medicine, Utrecht University, The Netherlands</li> <li>Department of Orthopaedics, University Medical Center Utrecht, The Netherlands </li> <li>School of Information Technology and Electrical Engineering, The University of Queensland, Brisbane, Australia</li> <li>Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland </li> </ol> <p> </p> <p>*Corresponding authors:<br> Mikko J. Nissi<br> Department of Applied Physics,<br> University of Eastern Finland<br> POB 1627,<br> FI-70211, Kuopio, Finland<br> mikko.nissi@uef.fi<br> +358-50-5955517</p> <p>Abdul Wahed Kajabi<br> Research Unit of Medical Imaging, Physics and Technology,<br> University of Oulu<br> POB 50,<br> FI-90029, Oulu, Finland<br> abdul.kajabi@oulu.fi<br> +358-50-3037425</p> <p>Keywords: cartilage, post-traumatic, osteoarthritis, quantitative MRI, relaxation times</p> <p>The file "Pony_AllData.mat" contains all the data of the study. The main struct variable in the file ("all_data") contains several fields storing all the data per sample. In the following, brief descriptions for the main subfields are given:</p> <ul> <li>name: contains generic name of the sample</li> <li>qMRI_Data: contains qMRI raw data, the corresponding relaxation time maps and normalized cartilage full-thickness ROI profiles</li> <li>calcROI_Data: contains ROIs used to calculate the relaxation time maps</li> <li>analysisROI_Data: ROIs used for the analysis</li> <li>DD_prof and interpDD_prof: Original and interpolated profiles for proteoglycan content (Optical Density)</li> <li>PLM_prof and interpPLM_prof: Original and interpolated profiles for collagen fiber orientation (Polarized Light Microscopy)</li> <li>E_eq and E_dyn: Equilibrium and dynamic moduli of articular cartilage.</li> </ul> <p>The example script, "Analysis_script.m" contains a short demonstration on how the data in the struct can be accessed. The script assumes that Aedes (http://aedes.uef.fi) analysis software is available for matlab.</p> <p>(Abdul Wahed Kajabi, 17 Jun 2020)</p>
Simultaneous bilateral unicompartmental knee replacement improves gait parameters in patients with bilateral knee osteoarthritis
<p>Background: Unicompartmental knee replacement (UKR) can provide reliable clinical and functional outcomes when performed simultaneously in both knees for treating bilateral osteoarthritis (OA). No studies to date have evaluated gait pattern after simultaneous bilateral UKR. The aim of this study was to evaluate changes in gait variables after bilateral single-stage UKR (B-UKR) and to compare them with the outcomes after unilateral UKR in two other groups of patients: one with bilateral knee OA (P-UKR) and one with the contralateral knee unaffected (H-UKR).<br> Methods: Three-dimensional motion cohort data were prospectively collected before and six months after surgery; 37 were allocated to the B-UKR (n =13), P-UKR (n= 12) or H-UKR (n = 12) group. Spatiotemporal variables (stride length, gait speed, gait cadence, stance phase, swing phase, and double support phase) and kinematic parameters (knee flexion and extension peak values, knee range of motion (ROM), and hip abduction peak value) were analyzed using mixed analysis of variance (ANOVA). The magnitude of effect for significant outcomes (ES) was determined using Cohen's d.<br> Results: Postoperative improvement in gait cadence (P b 0.01; ES=1.20), walking speed (P b 0.05; ES = 0.58), stride length (P b 0.05; ES = 0.67), knee ROM (P b 0.05; ES = 0.89), knee flexion (P b 0.05; ES=0.94), and hip abduction (P b 0.001; ES=1.16) was noted for the BUKR group, whereas only stride length improved (P b 0.05; ES=0.48) for the H-UKR group, and no changes in any gait parameter were seen for the P-UKR group.<br> Conclusions: Postoperative improvement in gait parameters was observed in the B-UKR patients with bilateral OA. Whenever possible, simultaneous bilateral UKR should be considered in such patients.</p>
Effects of a combination of polynucleotide and hyaluronic acid for treating osteoarthritis
<p><span>(A) Safranin O-Fast Green Staining. (B) OARSI score and grade in tibia and femur. n = 10 – 12 per group. Sham, sham operation; OA, osteoarthritis; </span><span>Cont</span><span>, control vehicle; PNHA/b, polynucleotide (2%) with hyaluronic acid (0.5%); HA, hyaluronic acid (0.5%). Relative to OA control: *p < 0.05, **p < 0.01, ***p < 0.0001 (unpaired t-test). The data are expressed as the mean ± SEM.</span></p>
Osteochondral explants as a reliable experimental model to test a promising cell-free approach against osteoarthritis
<p><a href="https://zenodo.org/record/4062030">Datasets of the paper 'Osteochondral explants as a reliable experimental model to test a promising cell-free approach against osteoarthritis</a>'</p>
Biomechanical Analysis of Limits of Stability Using Computerized Posturography: Correlations with Functional Mobility in Elderly Individuals with Hip Osteoarthritis – A Cross-Sectional Study
<p>The study titled "Biomechanical Analysis of Limits of Stability Using Computerized Posturography: Correlations with Functional Mobility in Elderly Individuals with Hip Osteoarthritis – A Cross-Sectional Study" delves into the intricate relationship between postural stability and functional mobility in elderly patients suffering from hip osteoarthritis (OA). Utilizing advanced computerized posturography, the research quantitatively assesses the limits of stability (LOS) in various directional planes, providing a comprehensive biomechanical profile of the participants. The findings reveal significant discrepancies in LOS between hip OA patients and age-matched asymptomatic controls, underscoring the profound impact of hip OA on balance and stability. Additionally, the study examines the correlation between LOS measurements and functional mobility, as assessed by the Timed Up and Go (TUG) test. The results indicate a strong association, suggesting that diminished postural stability in hip OA patients contributes to impaired functional mobility. This cross-sectional analysis highlights the importance of targeted interventions to enhance stability and mobility in this population, aiming to mitigate the risk of falls and improve overall quality of life.</p>
Ultrasound data in knee osteoarthritis in a co0mmunity-based healthcare facility
<p><span><strong>Abstract:</strong> Diagnostic ultrasound (US) has been increasingly used in knee osteoarthritis (OA)</span><span>. This cross-sectional study performed between <span>January 2022 and June 2023</span> delves into the correlation between OMERACT (effusion synovitis, medial femoral condylar cartilage thickness, MFC, and osteophyte) and non-OMERACT (medial meniscal extrusion, MME and Baker’s cyst, BC) in knee OA. </span><span>Continuous (non-normal) data are presented as median (range) and categorical data are presented frequency (percentage). Inter-rater reliability of US data between raters performed using weighted Cohen’s kappa coefficient (r). Association between dichotomized US data has been assessed using the Chi-square test (<em>X<sup>2</sup></em>), p<0.05 was the level of statistical significance. 8</span><span>3 patients with a median age was 57 were enrolled consecuteively. 55 were female. 56 (67.5%) had unilateral and 27 (32.5%) had bilateral knee pain. Quadriceps muscle wasting was observed in 35 (42.7%) patients. Clinical signs (massage test, fluctuation test and cross fluctuation test) of effusion were revealed in 24 (28.9%). Radiological OA changes were depicted in 59 (71.1%) cases. US characteristics were detected in 80 individuals (96.3%), including BC, MME, effusion synovitis, MFC cartilage thickness change, and medial knee joint line osteophyte in 28 (35.9%), 37 (48.1%), 42 (51.8%), 62 (81.6%), and 63 (80.7%) patients, respectively. BC were seen in 28 (35.9%) cases and beak-shaped was the most common cyst type. OMERACT-MFC cartilage thickness and medial joint line osteophyte, were seen statistically correlated with non-OMERACT (MME and BC). Effusion synovitis was correlated significantly with MME (p<.001) but not with BC (p=.145). <span> </span></span></p>
Efficacy and safety of different monoclonal antibodies for osteoarthritis: a Bayesian network meta-analysis
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Predictive factors of inpatient rehabilitation stay and post-discharge care burden after joint replacement for hip and knee osteoarthritis: a retrospective study on 1,678 patients.
<p>Dataset of the study entitled "<span>Predictive factors of inpatient rehabilitation stay and post-discharge care burden after joint replacement for hip and knee osteoarthritis: a retrospective study on 1,678 patients"</span></p>
Learning-based landmark detection in pelvis X-Rays with attention mechanism: Data from the Osteoarthritis Initiative
<p>We proposed a new landmark detection task based on the data from Osteoarthritis Initiative. We chose high-quality 544 images taken by the Swissray scanner from OAI bone image dataset. Images of the patients with hip replacement were excluded owing to the lack of anatomical structures that must be predicted, and some of the existing images that influenced the doctors labeling the landmarks were also excluded. In total, data of 524 subjects were collected to develop and validate a deep learning system to predict the landmarks in the pelvis images. According to our research problem, we invited professional doctors to label femoral head center, upper acetabulum rim, innermost point of subchondral sclerosis and teardrop in the pelvis X-Ray, as shown in the Figure 4. Total images were annotated by a radiologist with 7 years of working experience from the First Hospital of Jilin University, and the anatomical positions labeled were reviewed by orthopedic surgeon with 7 years of working experience from the Second Hospital of Jilin University.</p> <p>There are two files in this dataset. "Coordinates_information.xlsx" stored the coordinates of landmarks labeled by radiologist. "original_information.xlsx" was download from Osteoarthritis Initiative, which stored the basic information about X-rays.</p>
The Effect of Hybrid Tele-rehabilitation Versus In Person Rehabilitation on Pain and Function in Patients With Knee Osteoarthritis
ClinicalTrials.gov study NCT06956222. IPD Sharing: YES. Countries: 1. Publications: 1.
Chondromodulating Effect of Diacerein in Osteoarthritis of the Hip
ClinicalTrials.gov study NCT00451360. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Dose-ranging Study of the Safety and Effectiveness of JNJ-42160443 as add-on Treatment in Patients With Osteoarthritis-related Pain
ClinicalTrials.gov study NCT00973141. IPD Sharing: Not stated. Countries: 4. Publications: 1.
Immediate Effects of Manual Therapy Versus TENS in Patients With Knee Osteoarthritis
ClinicalTrials.gov study NCT02947451. IPD Sharing: NO. Countries: 1. Publications: 25.
Genicular Artery Embolization for Reducing Pain in Medically Refractory Symptomatic Knee Osteoarthritis
ClinicalTrials.gov study NCT06859164. IPD Sharing: UNDECIDED. Countries: 1. Publications: 13.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.