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SBF-SEM Dataset of Guinea Pig Fetal Day 55-59 Psoas Muscle

Multiple SBF-SEM datasets of Duncan Hartley guinea pigs at fetal day 55-59 from psoas muscle. Parameters for each of the datasets are attached as a spreadsheet, including nm resolution, image size, number of sections and section thickness.

SBF-SEM Dataset of Guinea Pig Fetal Day 60-64 Psoas Muscle

Multiple SBF-SEM datasets from 3 Duncan hartley guinea pig fetal day 60-64 psoas muscle. Parameters for each of the datasets are attached as a spreadsheet, including nm resolution, image size, number of sections and section thickness.

SBF-SEM Dataset of Guinea Pig Fetal Day 60-64 Soleus Muscle

Multiple SBF-SEM datasets from 3 Duncan hartley guinea pig fetal day 60-64 soleus muscle. Parameters for each of the datasets are attached as a spreadsheet, including nm resolution, image size, number of sections and section thickness.

SBF-SEM Dataset of Guinea Pig Fetal Day 50-54 Soleus Muscle

Multiple SBF-SEM datasets of Duncan Hartley guinea pigs at fetal day 50-54 from soleus muscle. Parameters for each of the datasets are attached as a spreadsheet, including nm resolution, image size, number of sections and section thickness.

opencc-by-4.0Feb 2019View details →

Cellular Contribution to Left and Right Atrial Dysfunction in Chronic Arterial Hypertension in Pigs

Aims: Atrial contractile dysfunction contributes to reduced cardiac output and worse prognosis. We investigate cellular mechanisms of left (LA) and right atrial (RA) contractile dysfunction in hypertensive heart disease (HHD) in pigs. Methods & Results: In vivo electrophysiological and magnetic resonance imaging (MRI) studies were performed in control (CTRL) and pigs treated with DOCA/high salt/glucose (12 weeks) to induce HHD. HHD lead to significant atrial remodeling and loss of contractile function in LA with a similar trend in RA (MRI), associated with higher inducibility of atrial fibrillation, but unrelated to changes in atrial refractory period or fibrosis (histology). Reduced atrial function in DOCA pigs was related to reduced contraction amplitude of LA (already at baseline) and RA myocytes (at higher frequencies) due to reduced intracellular Ca transient (CaT) amplitude (Fura 2-AM, field stimulation). LA cardiomyocytes showed reduced sarcoplasmic reticulum (SR) [Ca2+], whereas in RA, SR [Ca2+] was unchanged and SR Ca2+-ATPase (SERCA) activity was increased. Sodium calcium exchanger (NCX) activity was not altered. We used ORM-10103 (3 µM), a specific NCX inhibitor to improve Ca availability in LA and RA cardiomyocytes from DOCA pigs. Partial inhibition of NCX increased CaT amplitude and SR Ca2+ in LA, but not RA cells. Conclusion: HHD leads to loss of contractility and abnormal Ca2+ handling in LA and RA, suggesting improvement of atrial cardiomyocyte inotropy as a therpeutic target in HHD. Atrial site-specific remodeling modulates the outcome of NCX inhibitors on restoring atrial function.

opencc-by-4.0Mar 2019View details →

Supporting data and libraries used for statistical analysis for the article: "Targeted metabolomic profiling reveals differences in plasma metabolome of ovalbumin sensitised guinea pigs"

Supporting data and libraries used for statistical analysis for the article: "Targeted metabolomic profiling reveals differences in plasma metabolome of ovalbumin sensitised guinea pigs"

FIGURE 19 in Hidden in plain sight: reassessment of the pig-footed bandicoot, Chaeropus ecaudatus (Peramelemorphia, Chaeropodidae), with a description of a new species from central australia, and use of the fossil record to trace its past distribution

FIGURE 19. Unconstraint Bayesian analysis of Chaeropus using the morphological data, with posterior probabilities.

FIGURE 14 in Hidden in plain sight: reassessment of the pig-footed bandicoot, Chaeropus ecaudatus (Peramelemorphia, Chaeropodidae), with a description of a new species from central australia, and use of the fossil record to trace its past distribution

FIGURE 14. Bivariate plots of tooth length versus tooth width, for the upper a)–g) and lower h)–o) premolars and molars for modern and fossil Chaeropus ecaudatus ecaudatus (squares), C. e. occidentalis (diamonds) and C. yirratji sp. nov. (crosses).

FIGURE 11 in Hidden in plain sight: reassessment of the pig-footed bandicoot, Chaeropus ecaudatus (Peramelemorphia, Chaeropodidae), with a description of a new species from central australia, and use of the fossil record to trace its past distribution

FIGURE 11. Skulls and dentaries of Chaeropus yirratji sp. nov. skulls. a)–e), NMV C468, holotype, adult male; f)–j), SAMA M1618, paratype, adult male. a), f), d), i), dorsal/occlusal view; c), h), e), j), lateral/buccal view; b), g), ventral view. Scale = 2 cm.

FIGURE 10 in Hidden in plain sight: reassessment of the pig-footed bandicoot, Chaeropus ecaudatus (Peramelemorphia, Chaeropodidae), with a description of a new species from central australia, and use of the fossil record to trace its past distribution

FIGURE 10. Pouch young of Chaeropus yirratji sp. nov. a), SAMA M3997, three pouch young, two still attached to the teats; b)–d), NMV C5859, female pouch young. a), c), lateral view; b), dorsal view; d), ventral view. Scale = 2cm.

FIGURE 8 in Hidden in plain sight: reassessment of the pig-footed bandicoot, Chaeropus ecaudatus (Peramelemorphia, Chaeropodidae), with a description of a new species from central australia, and use of the fossil record to trace its past distribution

FIGURE 8. Skins of Chaeropus yirratji sp. nov. a)–b), NMV C468, holotype, adult male; c)–d), SAMA M1618, paratype, adult male; e), SAMA M2425, paratype, adult female; f), MNHN ZM MO-1853-824, paratype, adult, sex unknown. a), c), e), f), lateral view; b), d), dorsal view. Scale = 7 cm.

FIGURE 6 in Hidden in plain sight: reassessment of the pig-footed bandicoot, Chaeropus ecaudatus (Peramelemorphia, Chaeropodidae), with a description of a new species from central australia, and use of the fossil record to trace its past distribution

FIGURE 6. Skulls and dentary of Chaeropus ecaudatus occidentalis. a)–f), NHMUK ZD 1844.7.9.22, holotype, adult female; g)–i), QM JM 770, adult subfossil; j), WAM 71.3.141, adult subfossil; k), WAM 71.5.1, adult subfossil. a), g), f), dorsal/ occlusal view; b), h), e), lateral/buccal view; c), i), j), k), ventral view; d), lingual view. Scale = 2 cm.

FIGURE 18 in Hidden in plain sight: reassessment of the pig-footed bandicoot, Chaeropus ecaudatus (Peramelemorphia, Chaeropodidae), with a description of a new species from central australia, and use of the fossil record to trace its past distribution

FIGURE 18. Constraint Maximum Parsimony analysis of Chaeropus using the morphological data, with bootstrap values.

FIGURE 5 in Hidden in plain sight: reassessment of the pig-footed bandicoot, Chaeropus ecaudatus (Peramelemorphia, Chaeropodidae), with a description of a new species from central australia, and use of the fossil record to trace its past distribution

FIGURE 5. Skin of Chaeropus ecaudatus occidentalis. a)–c), NHMUK ZD 1844.7.9.22, holotype, adult female. a), dorsal view; b), lateral view; c), ventral view. Scale = 7 cm.

FIGURE 4 in Hidden in plain sight: reassessment of the pig-footed bandicoot, Chaeropus ecaudatus (Peramelemorphia, Chaeropodidae), with a description of a new species from central australia, and use of the fossil record to trace its past distribution

FIGURE 4. Upper and lower dentition of Chaeropus ecaudatus ecaudatus. a), c), AM PA422, holotype, juvenile female; b), c), NMV C2900, adult, sex unknown. a)–b), upper dentition in occlusal view; c)–d), lower dentition in occlusal view. Scale = 2mm. Abbreviations: co, cristid obliqua; end, entoconid; hyd, hypoconid; hyld, hypoconulid; mcl, metaconule; me, metacone; mecd, metacristid; med, metaconid; met, metastyle; mf, maxillary fenestra; pacd, paracristid; pad, paraconid; pc, paracone; phd, posthypocristid; pr, protocone; prd, protoconid; StA–D; stylar cusp A–D.

FIGURE 12 in Hidden in plain sight: reassessment of the pig-footed bandicoot, Chaeropus ecaudatus (Peramelemorphia, Chaeropodidae), with a description of a new species from central australia, and use of the fossil record to trace its past distribution

FIGURE 12. Upper and lower dentition of Chaeropus yirratji sp. nov. a), c), SAMA M1618, paratype, adult male; b), d), SAMA M3971, juvenile female. a)–b), upper dentition in occlusal view; c)–d), lower dentition in occlusal view. Scale = 2mm.

FIGURE 3 in Hidden in plain sight: reassessment of the pig-footed bandicoot, Chaeropus ecaudatus (Peramelemorphia, Chaeropodidae), with a description of a new species from central australia, and use of the fossil record to trace its past distribution

FIGURE 3. Skulls and dentaries of Chaeropus ecaudatus ecaudatus. a)–g), AM PA422, holotype, juvenile female; h)–m), NMV C2900, adult, sex unknown. a), h), g), m), dorsal/occlusal view; b), i), e), l), lateral/buccal view; c), j), ventral view; d), k), posterior view; f), lingual view. Scale = 2cm. Abbreviations: ab, auditory bulla; af, antorbital fossa; as, alisphenoid; bs, basisphenoid; cf, carotid foramen; inf, incisive foramen; iof, infraorbital foramen; lac, lacrimal; lacf, lacrimal foramen; lap, lateral accessory palatal fenestra; map, medial accessory palatal fenestra; mf, maxillary fenestra; mp, maxillopalatine fenestra; mx, maxilla; na, nasal; pa, parietal; pal, palatine; pe, petrosal; pf, palatine fenestra; pfo, primary foramen ovale; pmx, premaxilla; ps, presphenoid; sfo, secondary foramen ovale; tf, transverse foramen; tp, triangular shaped process; za, zygomatic arch.

FIGURE 17 in Hidden in plain sight: reassessment of the pig-footed bandicoot, Chaeropus ecaudatus (Peramelemorphia, Chaeropodidae), with a description of a new species from central australia, and use of the fossil record to trace its past distribution

FIGURE 17. Phylogenetic analyses of Chaeropus taxa using Maximum Likelihood (ML) and Bayesian Inference (BI) in an alignment where the hypervariable loops of the 12S and 16S and the 3rd codon of cytb were eliminated.

FIGURE 2 in Hidden in plain sight: reassessment of the pig-footed bandicoot, Chaeropus ecaudatus (Peramelemorphia, Chaeropodidae), with a description of a new species from central australia, and use of the fossil record to trace its past distribution

FIGURE 2. Skins of Chaeropus ecaudatus ecaudatus. a)–c), AM PA421, adult male; d)–f), NHMUK ZD 1847.8.14.12, adult female. a), d), lateral view; b), e), dorsal view; c), f), ventral view. Scale = 7 cm.

FIGURE 1 in Hidden in plain sight: reassessment of the pig-footed bandicoot, Chaeropus ecaudatus (Peramelemorphia, Chaeropodidae), with a description of a new species from central australia, and use of the fossil record to trace its past distribution

FIGURE 1. Distribution map for specimens of Chaeropus. Chaeropus ecaudatus ecaudatus in blue, C. e. occidentalis in green, C. yirratji sp. nov. in red, C. sp. indet. in black. Square = modern specimens; circles = subfossils (Holocene or younger in age); stars = Pleistocene fossils; triangles = oral history from Burbidge et al. (1988).