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204 results for “chronic migraine”
Identification of predictive biomarkers for the progression from episodic migraine to chronic migraine
<p>This database includes the raw data linked with the RF project, “ Identification of predictive biomarkers for the progression from episodic migraine to chronic migraine”. In this study, we reported results of the identification of biomarkers of progression of Episodic Migraine (EM) into Chronic Migraine with medication overuse (CM-MO). In order to achieve this objective, we investigated the possible factors associated to a risk of CM by comparing differences in genetic, clinical, psychological, serological and neurophysiological variables between EM and CM sufferers.</p> <p><strong>Methods. </strong>We compared in a paired case-control study 200 EM and 200 CM-MO patients with respect to clinical, psychological, biochemical and neurophysiological variables. Clinical variables were collected by headache neurologists and included: migraine history (i.e. EM/CM onset) and its characteristics, family history, present/previous use of medications/other substances, medical history, lifestyle habits. A psychopathological assessment has been performed by a trained psychologist and included also a series of questionnaires for assessing traumatic experiences, stressful life-events, anxiety and depression, Alexithymia, level of dependence. According to the project, we also conducted a case-control candidate gene association study aimed to evaluate the role of candidate single nucleotide polymorphisms (SNPs) as genetic predictors of migraine chronification. We selected SNPs in genes that are relevant for migraine pathophysiology, gene polymorphisms that have reached genome wide significance for migraine susceptibility, as well as SNPs in genes involved in risk for addiction and/or drug-seeking behavior. We firstly tested the potential correlations between SNPs and migraine chronification in an exploratory set of CM patients (cases) and EM patients (controls), enrolled for previously conducted research projects. Then, SNPs that emerged as nominally significant in the exploratory dataset (P<0.05) have been selected for validation in an independent confirmatory population generated by the recruitment of 200 EM and 200 with CM-MO patients enrolled in this study. Finally, a subset of 20 EM, 20 CM-MO patients and 20 Healthy Controls underwent the parallel evaluation of neurophysiological parameters and serological markers.</p> <p><strong>Results (in brief)</strong>. Here we report data from study involving 200 episodic migraine patients with a long history of migraine and 200 chronic migraine with medication overuse patients. We considered several aspects that may be involved in the development of chronic migraine. First, after a multivariate analysis we identified clinical factors associated to CM-MO, some of them expected, such as alcohol daily use, snoring, use of hypnotic and antidepressant drugs, hypertension, and the others unexpected, such as astenia as accompanying headache symptom and dysmenorrhea. In our study, CM-MO results characterized by a more complex psychopathological profile that affects different dimensions (more presence of anxiety and depressive symptoms, dependence level, early traumatic experiences). Plasma levels of calcitonin gene-related peptide (CGRP) and the expression of miR-34a-5p and miR-382-5p in peripheral blood mononuclear cells, were significantly higher in migraine subjects when compared to healthy volunteers. In the CM-MO group, detoxification significantly decreased CGRP levels and miRNAs expression. Plasma levels of Kynurenic Acyd were lower in all migraine patients when compared to controls, while levels of Kynolonic Acyd were similar in all groups. As neurophysiological correlate, we found no significant differences between migraine patients and HV for NWR threshold, single stimulus threshold, latency and area under the curve. Temporal summation threshold showed a higher trend in migraine patients when compared to control group, but this data has not been confirmed in the post-hoc analysis. Finally, genetic data showed that LRP1 rs11172113 single nucleotide polymorphism is associated with CM, while other SNPs investigated do not reach the significance.</p>
Data related to article EFFICACY OF MINDFULNESS ADDED TO TREATMENT AS USUAL IN PATIENTS WITH CHRONIC MIGRAINE AND MEDICATION OVERUSE HEADACHE: A PHASE-III SINGLE-BLIND RANDOMIZED-CONTROLLED TRIAL (THE MIND-CM STUDY) - submitted
<p>DATA ON PATIENTS INCLUDED IN THE MIND-CM STUDY. TWO ARMS (TAU AND TAU+MIND), AND FOUR EVALUATIONS: BASELINE, 3-MONTHS, 6-MONTHS AND 12-MONTS FOLLOW-UP.</p>
Theory of Mind assessed via real life materials in Chronic Migraine with Medication Overuse.
<p>Dataset refers to a study aimed to outline the Theory of Mind (ToM) functioning of patients with Chronic Migraine with Medication Overuse (CM+MO) compared to Episodic Migraine (EM) using the Movie for the Assessment of Social Cognition (MASC), a task consisting of the presentation of a 15-minute video clip of social interactions close to real life encounters in which participants are asked to identify and attribute mental states online. Seventy-two subjects were enrolled, of which 30 suffered from CM+MO and 42 from EM. All participants were assessed with a conventional ToM task, the Reading Mind in the Eyes test (RMET), and the MASC. We confirm impaired ToM performances in CM+MO with respect to EM when using the RMET. Interestingly, we also found that CM+MO when compared to EM were characterized by more marked deficits in the affective ToM dimension of the MASC with respect to the cognitive one and committed more hypomentalizing errors. This means that CM+MO patients may be more prone to under-interpret and misunderstand intended social interaction from another human being than the EM group. These findings have important theoretical and practical relevance in the field of CM+MO.</p>
Social cognition in Chronic Migraine with Medication Overuse: Do you mind what I think?
<p>This is the processed data for the manuscript “Bottiroli S, Rosi A, Sances G, Allena M, De Icco R, Lecce S, Vecchi T, Tassorelli C, Cavallini E. Social cognition in Chronic Migraine with Medication Overuse: Do you mind what I think?. To be submitted to JAMA Network Open”. </p> <p>Dataset refers to a study aimed to outline the socio-cognitive profile of patients with Chronic Migraine with Medication Overuse (CM+MO). Given the multidimensionality of the socio-cognitive construct, we considered: (1) socio-cognitive abilities, (2) socio-cognitive beliefs, (3) alexithymia and autism traits, and (4) social relationships. Two hundred and twelve subjects were enrolled, of which 71 suffered from CM+MO, 61 from episodic migraine (EM), and 80 were healthy controls (HC). All participants were assessed with a comprehensive socio-cognitive battery that included: (1) the Faux pas test (FP), the Strange Stories task (SS), the Reading Mind in the Eyes test (RMET), (2) the Tromso Social Intelligence Scale, (3) the Toronto Alexithymia Scale, (4) the Lubben Social Network Scale – Revised and the Friendship Scale. Data showed that CM+MO: (1) performed similar to EM but worse than HC in the FP and SS tests, while they were worse than the other two groups in the RMET; (2) were similar to EM and HC in terms of social intelligence; (3) had more alexithymic and autistic traits than EM and HC; and (4) reported higher levels of contact with their family members but felt little support from the people around them than HC. These results suggest that CM+MO patients are characterized by a profile of compromised socio-cognitive abilities that affects different dimensions.</p>
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