Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
412
datasets available to search
ShareScore release 0.7.1
Dataset results
412 results for “genetic risk”
Multi-ancestry genetic analysis of gene regulation in coronary artery prioritizes disease risk loci
GEO Series GSE225650. Homo sapiens. 138 samples. Type: Expression profiling by high throughput sequencing.
Functional genomics in primary T cells and monocytes identifies mechanisms by which genetic susceptibility loci influence systemic sclerosis risk
GEO Series GSE212100. Homo sapiens. 34 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Integrative Epigenome-Wide Analysis Shows That DNA Methylation May Mediate Genetic Risk In Inflammatory Bowel Disease
GEO Series GSE87650. Homo sapiens. 875 samples. Type: Expression profiling by array; Methylation profiling by genome tiling array.
Genetic Variants of Phospholipase C-γ2 Confer Altered Microglial Phenotypes and Differential Risk for Alzheimer’s Disease [NanoString]
GEO Series GSE221806. Mus musculus. 72 samples. Type: Other.
Conserved dorsal horn neuron subtype-specific enhancers are implicated in the genetic risk of chronic pain [Mouse Xenium]
GEO Series GSE253951. Mus musculus. 2 samples. Type: Other.
Genetic Variants of Phospholipase C-γ2 Confer Altered Microglial Phenotypes and Differential Risk for Alzheimer’s Disease [bulk RNA-seq]
GEO Series GSE237493. Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing.
Integrated single-cell chromatin and transcriptomic analyses of human scalp reveal etiological insights into genetic risk for hair and skin disease
GEO Series GSE212450. Homo sapiens. 23 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Genetic Variants of Phospholipase C-γ2 Confer Altered Microglial Phenotypes and Differential Risk for Alzheimer’s Disease [snRNA-seq]
GEO Series GSE237494. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Genetic variants affecting RNA stability influence complex traits and disease risk I
GEO Series GSE298112. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
DNA methylation in lung cells is a key modulator of asthma endotypes and genetic risk [DNA methylation]
GEO Series GSE85566. Homo sapiens. 115 samples. Type: Methylation profiling by array.
Single-nucleus sequencing reveals enriched expression of genetic risk factors in Extratelencephalic Neurons sensitive to degeneration in ALS
GEO Series GSE226753. Homo sapiens. 1 samples. Type: Expression profiling by high throughput sequencing.
Genetically perturbed myelin as a risk factor for neuroinflammation-driven axon degeneration
GEO Series GSE224032. Mus musculus. 3 samples. Type: Expression profiling by high throughput sequencing.
Conserved dorsal horn neuron subtype-specific enhancers are implicated in the genetic risk of chronic pain [Mouse snATAC-seq]
GEO Series GSE253952. Mus musculus. 12 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Genetic Differences in the Immediate Transcriptome Response to Stress Predict Risk-Related Brain Function and Psychiatric Disorders
GEO Series GSE46743. Homo sapiens. 320 samples. Type: Expression profiling by array.
Multi-omics co-localization with genome-wide association studies reveals a context-specific genetic mechanism at a childhood onset asthma risk locus [RNA-Seq]
GEO Series GSE172367. Homo sapiens. 190 samples. Type: Expression profiling by high throughput sequencing.
Integrative Epigenome-Wide Analysis Shows That DNA Methylation May Mediate Genetic Risk In Inflammatory Bowel Disease [Cells, Methylation profiling]
GEO Series GSE87640. Homo sapiens. 240 samples. Type: Methylation profiling by genome tiling array.
Chromatin looping links target genes with genetic risk loci for dermatological traits
GEO Series GSE151193. Homo sapiens. 17 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other.
Spatial genetic structure to identify populations at risk
<p>Microsatellite genotypes, locality information, and raster data for Miller et al</p>
Mild behavioral impairment in early Alzheimer's disease and its association with APOE and BDNF risk genetic polymorphisms
<p>Mild behavioral impairment (MBI) has been commonly reported in early Alzheimer’s disease (AD) but rarely using biomarker-defined samples. It is also unclear whether genetic polymorphisms influence MBI in such individuals. We thus aimed to examine the association between the cognitive status of participants (amnestic mild cognitive impairment (aMCI-AD) vs cognitively normal (CN) older adults) and MBI severity. Within aMCI-AD, we further examined the association between APOE and BDNF risk genetic polymorphisms and MBI severity.</p> <p>We included 62 aMCI-AD participants and 50 CN older adults from the Czech Brain Aging Study. The participants underwent neurological, comprehensive neuropsychological examination, APOE and BDNF genotyping, and magnetic resonance imaging. MBI was diagnosed with the Mild Behavioral Impairment Checklist (MBI-C), and the diagnosis was based on the MBI-C total score ≥ 7. Additionally, self-report instruments for anxiety (the Beck Anxiety Inventory) and depressive symptoms (the Geriatric Depression Scale-15) were administered. The participants were stratified based on the presence of at least one risk allele in genes for APOE (i.e., e4 carriers and non-carriers) and BDNF (i.e., Met carriers and non-carriers). We used linear regressions to examine the associations.</p> <p>MBI was present in 48.4% of the aMCI-AD individuals. Compared to the CN, aMCI-AD was associated with more affective, apathy, and impulse dyscontrol but not social inappropriateness or psychotic symptoms. Furthermore, aMCI-AD was related to more depressive but not anxiety symptoms on self-report measures. Within the aMCI-AD, there were no associations between <em>APOE</em> e4 and <em>BDNF</em> Met and MBI-C severity. However, a positive association between Met carriership and self-reported anxiety appeared.</p> <p>MBI is frequent in aMCI-AD and related to more severe affective, apathy, and impulse dyscontrol symptoms. <em>APOE</em> and <em>BDNF</em> polymorphisms were not associated with MBI severity separately; however, their combined effect warrants further investigation.</p>
Genetic Test Based Risk Prediction of Early Calcific Aortic Valve Disease in Patients With Bicuspid Aortic Valve
ClinicalTrials.gov study NCT06153407. IPD Sharing: NO. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.