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846 results for “homologs”
Safety, Tolerability, and Immunogenicity Study of Homologous Ad26 Mosaic Vector Vaccine Regimens or Heterologous Ad26 Mosaic and MVA Mosaic Vector Vaccine Regimens With Glycoprotein 140 (gp140) for Hu
ClinicalTrials.gov study NCT02315703. IPD Sharing: Not stated. Countries: 5. Publications: 2.
Trial Evaluating the Efficacy of CARBOPLATIN in Metastatic Prostate Cancer With Gene Alterations in the Homologous Recombination Pathway
ClinicalTrials.gov study NCT03652493. IPD Sharing: NO. Countries: 1. Publications: 1.
Data from: Duplication and sub/neofunctionalization of Malvolio, an insect homolog of Nramp, in the subsocial beetle Nicrophorus vespilloides
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Data from: The origins of novelty from within the confines of homology: the developmental evolution of the digging tibia of dung beetles
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Data from: Complex evolution of insect insulin receptors and homologous decoy receptors, and functional significance of their multiplicity
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Calponin-Homology Domain mediated bending of membrane associated actin filaments
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Data from: Remote homolog detection places insect chemoreceptors in a cryptic protein superfamily spanning the tree of life
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SCC3 is an axial element essential for homologous chromosome pairing and synapsis
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Data for: Insect homolog of oxytocin/vasopressin associated with parenting of males but not females in a subsocial beetle
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Acute pseudo-landmarking and Constellation homologies: A generalized workflow to identify and track segmented structures in plant time series images
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A Cambrian spiny stem mollusc and the deep homology of lophotrochozoan scleritomes
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Performance of virtual screening against GPCR homology models: Impact of template selection and treatment of binding site plasticity
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Data from: Divergent color signals from homologous unfeathered ornaments in two congeneric grouse
Color-based visual signals are important aspects of communication throughout the animal kingdom. Individuals evaluate color to obtain information about age and condition and to behave accordingly. Birds display a variety of striking, conspicuous colors and make ideal subjects for the study of color signaling. While most studies of avian color focus on plumage, bare unfeathered body parts also display a wide range of color signals. Mate choice and intrasexual competitive interactions are easily observed in lekking grouse, which also signal with prominent unfeathered color patches. Most male grouse have one pair of colorful bare part ornaments (combs), and males of several species also have inflatable air sacs in their throat. Previous studies have mostly focused on comb color and size, but little is known about the signaling role of air sac color. We measured comb size and the color properties of combs and air sacs in the Lesser and Greater Prairie-Chicken (Tympanuchus pallidicinctus and T. cupido, respectively), and investigated whether these properties varied with age and mass. We found that mass predicted color properties of air sacs and that age predicted comb size in the Greater Prairie-Chicken, suggesting that these ornaments indicate condition-dependence. No conclusive relationships between color and age or size were detected in the Lesser Prairie-Chicken. Color properties of both ornaments differed between the two species. Further research is needed to determine mechanisms that link condition to color and whether the information advertised by color signals from these ornaments is intended for males, females, or both.
Structure of transmembrane domain of mouse NBCe1 by homology modeling
<p>The structure model of the transmembrane domain of mouse NBCe1 was generated by SWISS-MODEL with the cryo-EM structure of human NBCe1 (PDB ID: 6CAA) as the template. Residues 445–1007 of mouse NBCe1-B was aligned with the homologous region of human NBCe1 by using SWISS-MODEL. The sequence identity between the two sequences is 96.09%. Structural assessment shows that the simulated model of mouse NBCe1 had QMEAN value −6.86, Cβ −3.57, solvation value −1.80, torsion value −5.49, and scored 1.49 by MolProbity approach.</p>
Systemic paralogy and function of retinal determination network homologs in arachnids
<p>Arachnids are important components of cave ecosystems and display many examples of troglomorphisms, such as blindness, depigmentation, and elongate appendages. Little is known about how the eyes of arachnids are specified genetically, let alone the mechanisms for eye reduction and loss in troglomorphic arachnids. Additionally, paralogy of Retinal Determination Gene Network (RDGN) homologs in spiders has convoluted functional inferences extrapolated from single-copy homologs in pancrustacean models. Here, we investigated a sister species pair of Israeli cave whip spiders (Arachnopulmonata, Amblypygi, <i>Charinus</i>) of which one species has reduced eyes. We generated the first embryonic transcriptomes for Amblypygi, and discovered that several RDGN homologs exhibit duplications. We show that paralogy of RDGN homologs is systemic across arachnopulmonates (arachnid orders that bear book lungs), rather than being a spider-specific phenomenon. A differential gene expression (DGE) analysis comparing the expression of RDGN genes in field-collected embryos of both species identified candidate RDGN genes involved in the formation and reduction of eyes in whip spiders. To ground bioinformatic inference of expression patterns with functional experiments, we interrogated the function of three candidate RDGN genes identified from DGE in a spider, using RNAi in the spider <i>Parasteatoda tepidariorum</i>. We provide functional evidence that one of these paralogs, <i>sine oculis/Six1 A </i>(<i>soA</i>), is necessary for the development of all arachnid eye types. Our results support the conservation of at least one RDGN component across Arthropoda and establish a framework for investigating the role of gene duplications in arachnid eye diversity.</p>
Raw diffraction images of the second bromodomain of Pleckstrin homology domain interacting protein (PHIP) (space group C2)
<p>Raw diffraction images of the second bromodomain of Pleckstrin homology domain interacting protein (PHIP) (space group C2). The final structure is deposited in the Protein Data Bank under accession code <a href="https://www.ebi.ac.uk/pdbe/entry/pdb/7AV9">7AV9</a>.</p> <p> </p> <p>Additional information:</p> <p>dataset: PHIPA-x1724<br> beamline: Diamond Light Source I04-1<br> visit: nt11175-63<br> date: 16-04-2015<br> Ω Start: 144.0°<br> Ω Osc: 0.12°<br> Ω Overlap: 0°<br> No. Images: 1500<br> Resolution: 1.50Å<br> Wavelength: 0.9173Å<br> Exposure: 0.040s<br> Transmission: 100.00%<br> Beamsize: 60x50μm</p>
Raw diffraction images of the second bromodomain of Pleckstrin homology domain interacting protein (PHIP) (space group P212121)
<p>Raw diffraction images of the second bromodomain of Pleckstrin homology domain interacting protein (PHIP) (space group P212121). The final structure is deposited in the Protein Data Bank under accession code <a href="https://www.ebi.ac.uk/pdbe/entry/pdb/7BBO">7BBO</a>.</p> <p> </p> <p>Additional information:</p> <p>dataset: PHIPA-x1738<br> beamline: Diamond Light Source I04-1<br> visit: nt11175-63<br> date: 16-04-2015<br> Ω Start: 90.0°<br> Ω Osc: 0.12°<br> Ω Overlap: 0°<br> No. Images: 1500<br> Resolution: 1.50Å<br> Wavelength: 0.9173Å<br> Exposure: 0.040s<br> Transmission: 100.00%<br> Beamsize: 60x50μm</p>
Raw diffraction images of the second bromodomain of Pleckstrin homology domain interacting protein (PHIP) in complex with H4K5acK8ac
<p>Raw diffraction images of the second bromodomain of Pleckstrin homology domain interacting protein (PHIP) in complex with H4K5acK8ac. The final structure is deposited in the Protein Data Bank under accession code <a href="https://www.ebi.ac.uk/pdbe/entry/pdb/7BBP">7BBP</a>.</p> <p> </p> <p>Additional information:</p> <p>dataset: PHIPA-x2179<br> beamline: Diamond Light Source I04-1<br> visit: mx10619-76<br> date: 20-06-2016<br> Ω Start: 216.3°<br> Ω Osc: 0.15°<br> Ω Overlap: 0°<br> No. Images: 1200<br> Resolution: 2.00Å<br> Wavelength: 0.9282Å<br> Exposure: 0.050s<br> Transmission: 100.00%</p>
Raw diffraction images of the second bromodomain of Pleckstrin homology domain interacting protein (PHIP) (space group p21212)
<p>Raw diffraction images of the second bromodomain of Pleckstrin homology domain interacting protein (PHIP) (space group p21212). The final structure is deposited in the Protein Data Bank under accession code <a href="https://www.ebi.ac.uk/pdbe/entry/pdb/7AV8">7AV8</a>.</p> <p>Additional information:</p> <p>dataset: PHIPA-x152<br> beamline: Diamond Light Source I04-1<br> visit: mx8421-63<br> date: 02-03-2014<br> Ω Start: 90.0°<br> Ω Osc: 0.10°<br> Ω Overlap: 0°<br> No. Images: 1800<br> Resolution: 1.50Å<br> Wavelength: 0.9200Å<br> Exposure: 0.050s<br> Transmission: 100.00%<br> Beamsize: 60x50μm</p>
FIGURE 1 in Use of scalation landmarks in geometric morphometrics of squamate reptiles: a comment on homology
FIGURE 1. Diagrams of specimens of the Crotalus viridis complex with 14 (A) and 16 (B) supralabial scales, respectively (supralabial scale rows are shaded in grey). For (A), the red dot marks a fixed landmark at the center of the series, seven scales from the first and seven scales from the last supralabial scale. Placing a corresponding fixed landmark on specimen B requires that one choose between seven scales from the first supralabial, seven scales from the last supralabial, or the suture at the center of the series, providing three mutually exclusive options (red dots). Selecting any of these options changes the topological position of the landmark relative to the first, the last, or both of these scales in the series. Fixed landmarks applied to scale rows variable in count renders secondary homology intractable, regardless of whether scales are counted from a consistent anchor point.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.