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Dataset results
217 results for “precision medicine”
A PRECISION MEDICINE APPROACH TO INTERROGATE GENE EXPRESSION PATTERNS IN AFRICAN MEN PRESENTING WITH EARLY STAGE PROSTATE CANCER.
GEO Series GSE157665. Homo sapiens. 67 samples. Type: Expression profiling by high throughput sequencing.
Comparing gene expression across primary human airway models for cystic fibrosis precision medicine
GEO Series GSE172232. Homo sapiens. 71 samples. Type: Expression profiling by high throughput sequencing.
Patient-Derived Xenografts of Upper Tract Urothelial Cell Carcinoma: a tool for precision medicine
GEO Series GSE134292. Homo sapiens. 80 samples. Type: Expression profiling by high throughput sequencing.
Functional precision medicine identifies new therapeutic candidates for medulloblastoma (methylation dataset)
GEO Series GSE151344. Homo sapiens. 30 samples. Type: Methylation profiling by genome tiling array.
NCI-COG Pediatric MATCH Precision Medicine Clinical Trial
NCI-COG Pediatric MATCH is a cancer treatment clinical trial for children, teens, and young adults, aged 1 to 21 years, that is testing the use of precision medicine for childhood cancers. In this trial, young people with solid tumors that are not responding to treatment are assigned to an experimental treatment based on the genetic changes found in their tumors rather than on their type of cancer or cancer site. The genetic changes are found through genomic sequencing, which is a laboratory method used to determine the genetic makeup of cancer cells.
Childhood Cancer Data Initiative (CCDI): Molecular Characterization across Pediatric Brain Tumors and Other Solid and Hematologic Malignancies for Research, Diagnostic, and Precision Medicine
This study contains tumor and germline WGS, RNA-Seq, Clinical Panel Sequencing, and other omics and molecular data for patients with pediatric brain tumors and other solid and hematologic malignancies. This data has been collected from multiple organizations including the multi-institute Children's Brain Tumor Network (CBTN), the Pacific Pediatric Neuro-Oncology Consortium (PNOC), and the Children's Hospital of Philadelphia Division for Genomic Diagnostics (CHOP DGD). In 2019, the CBTN launched the Pediatric Brain Tumor Atlas, which now comprises the largest collection of childhood brain tumor data in the world. This resource is helping accelerate not only brain tumor research, but is also empowering discovery for other rare childhood conditions. This sequencing cohort defines the largest, clinically annotated pediatric brain tumor cohort study to date and seeks to define the intersection of germline and somatic underpinnings of pediatric brain tumors across a shared developmental context of cancer and structural birth defects.
Molecular Characterization across Pediatric Brain Tumors and Other Solid and Hematologic Malignancies for Research, Diagnostic, and Precision Medicine
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NCI-COG Pediatric MATCH Precision Medicine Clinical Trial
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Depicting the Implementation Process for Precision Medicine
<p>Figure 1. Depicting the Implementation Process for Precision Medicine. This figure describes the iterative and complex, often messy, process that frames translational research from discovery to product and implementation. It outlines the various strategies required to transfer knowledge, synthesize and integrate it and how this influences approval, availability and adoption in the health care system. This highlights the importance of ‘upstream’ evidence on validity and utility as the foundation for effective approaches to implementation.</p>
Genomic and transcriptomic profiling expands precision cancer medicine: the WINTHER trial (Lung patients)
GEO Series GSE171702. Homo sapiens. 32 samples. Type: Expression profiling by array.
Functional precision medicine identifies new therapeutic candidates for medulloblastoma
GEO Series GSE151345. Homo sapiens. 57 samples. Type: Expression profiling by array; Methylation profiling by genome tiling array.
NCI-COG Pediatric MATCH Precision Medicine Clinical Trial
NCI-COG Pediatric MATCH is a cancer treatment clinical trial for children, teens, and young adults, aged 1 to 21 years, that is testing the use of precision medicine for childhood cancers. In this trial, young people with solid tumors that are not responding to treatment are assigned to an experimental treatment based on the genetic changes found in their tumors rather than on their type of cancer or cancer site. The genetic changes are found through genomic sequencing, which is a laboratory method used to determine the genetic makeup of cancer cells.
Molecular Characterization across Pediatric Brain Tumors and Other Solid and Hematologic Malignancies for Research, Diagnostic, and Precision Medicine
This study contains tumor and germline WGS, RNA-Seq, Clinical Panel Sequencing, and other omics and molecular data for patients with pediatric brain tumors and other solid and hematologic malignancies. This data has been collected from multiple organizations including the multi-institute Children's Brain Tumor Network (CBTN), the Pacific Pediatric Neuro-Oncology Consortium (PNOC), and the Children's Hospital of Philadelphia Division for Genomic Diagnostics (CHOP DGD). In addition to being available pre-publication and without embargo via dbGaP and the NCI Cancer Research Data Commons, this data is made available via Cavatica, PedcBioPortal and the Kids First Data Resource Portal. Collectively, this availability strives to accelerate the research process and enable members of the scientific and patient communities to partner and make discoveries faster than ever before. In 2019, the CBTN launched the Pediatric Brain Tumor Atlas, which now comprises the largest collection of childhood brain tumor data in the world. This resource is helping accelerate not only brain tumor research, but is also empowering discovery for other rare childhood conditions. Brain tumors are the most common form of cancer in children aged 0-19 in the United States, and are the largest cause of cancer-related deaths. The estimated number of new cases in 2019 is nearly 3,800, and thus brain tumors are a rare disease. Despite their relative rarity, the years of potential life lost due to brain tumors in 2009 was estimated at 47,631 years for children and adolescents aged 0-19 in the United States; this is a disproportionate amount of life lost compared to adult cancers and represents an unrecognized societal threat. There is an urgent need to improve therapies for these children. This sequencing cohort defines the largest, clinically annotated pediatric brain tumor cohort study to date and seeks to define the intersection of germline and somatic underpinnings of pediatric brain tumors across a shared developmental context of cancer and structural birth defects.
NCI-COG Pediatric MATCH Precision Medicine Clinical Trial
NCI-COG Pediatric MATCH is a cancer treatment clinical trial for children, teens, and young adults, aged 1 to 21 years, that is testing the use of precision medicine for childhood cancers. In this trial, young people with solid tumors that are not responding to treatment are assigned to an experimental treatment based on the genetic changes found in their tumors rather than on their type of cancer or cancer site. The genetic changes are found through genomic sequencing, which is a laboratory method used to determine the genetic makeup of cancer cells.
Dataset for the project "Towards precision medicine in psychiatry: clinical validation of a combinatorial pharmacogenomic approach" Italian Ministry of Health, Italy, Ricerca Finalizzata (Grant RF-2016-02361697)
<p><strong>Dataset for the project “Towards precision medicine in psychiatry: clinical validation of a combinatorial pharmacogenomic approach” Italian Ministry of Health, Italy, Ricerca Finalizzata (Grant RF-2016-02361697)</strong></p> <p><strong>Aim 1</strong>: Assessment of the validity and clinical utility of a pharmacogenetic test in the selection of antidepressant treatment for patients with Major Depressive Disorder.</p> <p><strong>Aim 2</strong>: Pharmacokinetic analysis and identification of novel genetic variants linked with no response to treatment and/or with the occurrence of side effects.</p> <p><strong>Aim 3</strong>: Implementation of the combinatorial algorithm based on possible new findings.</p> <p>This dataset contains :</p> <ul> <li><strong>RawData_Aim1</strong></li> </ul> <p>· Materials and Methods for Aim 1 (Materials and methods_RawData_Aim1)</p> <p>· An Excel table (RF16 - Genotyping - Aim1) with the following sheets:</p> <p>- Sheet 1: Genotyping results</p> <p>- Sheet 2: Metabolizer phenotype results for CYP2D6 and CYP2C19 genes</p> <ul> <li><strong>RawData_Aim2</strong></li> </ul> <p>· Materials and methods Sequencing_RawData_Aim2</p> <p>· Materials and methods Pharmacokinetics_RawData_Aim2</p> <p>· VCF data from sequencing analysis (filtered_variants - Aim2)</p> <p>· Pharmacokinetics analysis (Pharmacokinetics Data_Aim2)</p> <ul> <li><strong>RawData_Aim3</strong></li> </ul> <p>· An Excel table with data from clinical assessments (Clinical Data_Aim3)</p>
Molecular Characterization across Pediatric Brain Tumors and Other Solid and Hematologic Malignancies for Research, Diagnostic, and Precision Medicine
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NCI-COG Pediatric MATCH Precision Medicine Clinical Trial
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.