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2,461 results for “Rheumatoid arthritis”
TH17 cells converted into exTH17 cells sustain rheumatoid-like IL-17–independent inflammatory arthritis
GEO Series GSE234597. Mus musculus. 21 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Serum exosomes lncRNAs: TCONS_I2_00013502 and ENST00000363624 are new diagnostic markers for rheumatoid arthritis
GEO Series GSE271161. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Lactylated histone promotes rheumatoid arthritis progression by increasing NFATc2 expression and the production of anti-lactylated histone autoantibodies
GEO Series GSE284403. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Human umbilical cord mesenchymal stem cell-derived exosomes deliver miRNA-451a targeting ATF2 to inhibit rheumatoid arthritis.
GEO Series GSE237993. Homo sapiens. 27 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
Expression data of synovial cells isolated from patients with rheumatoid arthritis
GEO Series GSE9329. Homo sapiens. 2 samples. Type: Expression profiling by array.
Rheumatoid arthritis associated microRNA in peripheral blood mononuclear cells
GEO Series GSE124373. Homo sapiens; synthetic construct. 46 samples. Type: Non-coding RNA profiling by array.
IGF2BP3-mediated m6A modification of RASGRF1 promoting joint injury in rheumatoid arthritis [RIP-seq]
GEO Series GSE273246. Homo sapiens. 8 samples. Type: Other.
Whole blood gene expression of rheumatoid arthritis
GEO Series GSE93272. Homo sapiens. 275 samples. Type: Expression profiling by array.
Expression data from whole blood sample of eight kinds of TCM syndromes of rheumatoid arthritis patients.
GEO Series GSE205962. Homo sapiens. 20 samples. Type: Expression profiling by array.
Comprehensive Epigenetic Landscape of Rheumatoid Arthritis Fibroblast-like Synoviocytes [ChIP-seq]
GEO Series GSE112655. Homo sapiens. 152 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
The Mechanisms for the Therapeutic Effects of Tripterygium Wilfordii Hook on Rheumatoid Arthritis
Open the record for dataset details and reuse information.
Dataset related to article "Circulating and synovial Pentraxin-3 (PTX3) expression levels correlate with rheumatoid arthritis severity and tissue infiltration indepndently of comventional treatements response."
<p>This record contains raw data related to article “Circulating and synovial Pentraxin-3 (PTX3) expression levels correlate with rheumatoid arthritis severity and tissue infiltration indepndently of comventional treatements response."</p> <p><strong>Aims: </strong>To determine the relationship between PTX3 systemic and synovial levels and the clinical features of rheumatoid arthritis (RA) in a cohort of early, treatment naïve patients and to explore the relevance of PTX3 expression in predicting response to conventional-synthetic (cs) Disease-Modifying-Anti-Rheumatic-Drugs (DMARDs) treatment.</p> <p><strong>Methods: </strong>PTX3 expression was analyzed in 119 baseline serum samples from early naïve RA patients, 95 paired samples obtained 6-months following the initiation of cs-DMARDs treatment and 43 healthy donors. RNA-sequencing analysis and immunohistochemistry for PTX3 were performed on a subpopulation of 79 and 58 synovial samples, respectively, to assess PTX3 gene and protein expression. Immunofluorescence staining was performed to characterize PTX3 expressing cells within the synovium.</p> <p><strong>Results: </strong>Circulating levels of PTX3 were significantly higher in early RA compared to healthy donors and correlated with disease activity at baseline and with the degree of structural damages at 12-months. Six-months after commencing cs-DMARDs, a high level of PTX3, proportional to the baseline value, was still detectable in the serum of patients, regardless of their response status. RNA-seq analysis confirmed that synovial transcript levels of PTX3 correlated with disease activity and the presence of mediators of inflammation, tissue remodeling and bone destruction at baseline. PTX3 expression in the synovium was strongly linked to the degree of immune cell infiltration, the presence of ectopic lymphoid structures and seropositivity for autoantibodies. Accordingly, PTX3 was found to be expressed by numerous synovial cell types such as plasma cells, fibroblasts, vascular and lymphatic endothelial cells, macrophages, and neutrophils. The percentage of PTX3-positive synovial cells, although significantly reduced at 6-months post-treatment as a result of global decreased cellularity, was similar in cs-DMARDs responders and non-responders.</p> <p><strong>Conclusion: </strong>This study demonstrates that, early in the disease and prior to treatment modification, the level of circulating PTX3 is a reliable marker of RA activity and predicts a high degree of structural damages at 12-months. In the joint, PTX3 associates with immune cell infiltration and the presence of ectopic lymphoid structures. High synovial and peripheral blood levels of PTX3 are associated with chronic inflammation characteristic of RA. Additional studies to determine the mechanistic link are required.</p>
A Study of CH-4051 in Patients With Rheumatoid Arthritis (RA)
ClinicalTrials.gov study NCT01116141. IPD Sharing: Not stated. Countries: 0. Publications: 0.
A Study of The Effect of RoActemra/Actemra (Tocilizumab) in Combination With Methotrexate on Articular Damage in The Hand in Patients With Moderate to Severe Rheumatoid Arthritis Who Have an Inadequat
ClinicalTrials.gov study NCT01878318. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Therapy of Niacin for Rheumatoid Arthritis
ClinicalTrials.gov study NCT07004725. IPD Sharing: Not stated. Countries: 0. Publications: 0.
The Effect of Square Dance on Rheumatoid Arthritis
ClinicalTrials.gov study NCT02258269. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Efficacy and Safety of TwHF and MTX in Patients With Rheumatoid Arthritis
ClinicalTrials.gov study NCT03324412. IPD Sharing: NO. Countries: 0. Publications: 0.
Topical Compound Tripterygium Wilfordii Hook F for Patients With Active Rheumatoid Arthritis
ClinicalTrials.gov study NCT01961505. IPD Sharing: NO. Countries: 0. Publications: 0.
Very Low Dose Prednisolone on Newly Diagnosed Rheumatoid Arthritis
ClinicalTrials.gov study NCT07252271. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Open-Label Extension Safety Study of PROCRIT in Patients With Anemia of Chronic Disease Due to Rheumatoid Arthritis
ClinicalTrials.gov study NCT00123149. IPD Sharing: Not stated. Countries: 0. Publications: 0.
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.