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restrictedMar 2020View details →

Dataset related to article "Risk factors for chronic inflammatory demyelinating polyradiculoneuropathy (CIDP): antecedent events, lifestyle and dietary habits. Data from the Italian CIDP Database"

BACKGROUND AND PURPOSE: The role of lifestyle and dietary habits and antecedent events has not been clearly identified in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). METHODS: Information was collected about modifiable environmental factors and antecedent infections and vaccinations in patients with CIDP included in an Italian CIDP Database. Only patients who reported not having changed their diet or the lifestyle habits investigated in the study after the appearance of CIDP were included. The partners of patients with CIDP were chosen as controls. Gender-matched analysis was performed with randomly selected controls with a 1:1 ratio of patients and controls. RESULTS: Dietary and lifestyle data of 323 patients and 266 controls were available. A total of 195 cases and 195 sex-matched controls were used in the analysis. Patients eating rice at least three times per week or eating fish at least once per week appeared to be at decreased risk of acquiring CIDP. Data on antecedent events were collected in 411 patients. Antecedent events within 1-42 days before CIDP onset were reported by 15.5% of the patients, including infections in 12% and vaccinations in 1.5%. Patients with CIDP and antecedent infections more often had an acute onset of CIDP and cranial nerve involvement than those without these antecedent events. CONCLUSIONS: The results of this preliminary study seem to indicate that some dietary habits may influence the risk of CIDP and that antecedent infections may have an impact on the onset and clinical presentation of the disease.

restrictedDec 2020View details →

Dataset related to article "Linac-based stereotactic body radiation therapy for low and intermediate-risk prostate cancer : Long-term results and factors predictive for outcome and toxicity"

This record contains raw data related to article “Linac-based stereotactic body radiation therapy for low and intermediate-risk prostate cancer : Long-term results and factors predictive for outcome and toxicity" Introduction: Stereotactic body radiation therapy (SBRT) is considered an effective and safe treatment in patients with low- and intermediate-risk prostate cancer (PC). However, due to a lack of long-term follow-up and late toxicity data, this treatment is not universally accepted. The present study aimed to evaluate outcome and early and late toxicity in a cohort of patients with low- and intermediate-risk PC treated prospectively with linear accelerator (linac)-based SBRT. Patients and methods: Patients with low- or intermediate-risk (NCCN criteria) PC were included. All patients received linac-based SBRT to 35 Gy in 5 fractions delivered on alternate days. Endpoints were toxicity, biochemical relapse-free survival (BRFS), metastatic progression-free survival (mPFS), and overall survival (OS). Results: From 2012 to 2018, 178 patients were treated. Median baseline prostate-specific antigen (iPSA) was 6.37 ng/ml (range 1.78-20). Previous transurethral resection of the prostate (TURP) was present in 23 (12.9%) patients. Median follow-up was 58.9 months (range 9.7-89.9). BRFS rates at 1, 3, and 5 years were 98.3 (95% confidence interval, CI, 94.7-99.4%), 94.4 (95%CI 89.4-97), and 91.6% (95%CI 85.4-95.2), respectively. In univariate analysis, performance status (PS), iPSA, and nadir PSA (nPSA) were correlated with BRFS. In multivariable analysis iPSA and nPSA remained significant. BRFS rates at 5 years were 94.9% (95%CI 86.8-98) for International Society of Urological Pathology (ISUP) grade group 1, 93.2% (95%CI 80.5-97.7) for ISUP group 2, and 74.8% (95%CI 47.1-89.5) for ISUP group 3. At 1, 3, and 5 years, mPFS rates were 98.8 (95%CI 95.5-99.7), 96.2 (95%CI 91.9-98.3), and 92.9% (95%CI 87.2-96.2), respectively; OS rates were 100, 97.2 (95%CI 92.9-98.9), and 95.1% (95%CI 90-97.6), respectively. One (0.56%) case of grade 3 acute genitourinary (GU), one case of acute gastrointestinal (GI), and one case of grade 3 late GU toxicity were observed. GI toxicity positively correlated with prostate volume. Conclusion: At long-term follow-up, linac-based SBRT continues to be a valid option for the management localized PC. Biochemical control remains high at 5 years, albeit with some concerns regarding the optimal schedule for unfavorable intermediate-risk PC. Considering the excellent prognosis, patient selection is crucial for prevention of severe late toxicity.

restrictedcc-by-4.0Aug 2024View details →

Hepatocellular Carcinoma incidences and risk factors in Hepatitis C Patients: Interferon versus Direct-Acting Agents

Table S1: Comparisons of baseline clinical characteristics between patients treated with DAA and IFN after propensity score matching. Table S2: Univariate and multivariate cox regression model for HCC after propensity score matching. Table S3: Univariate and multivariate cox regression model for early HCC (<3 years). Table S4: Univariate and multivariate cox regression model for late HCC (3-6 years). Figure S1: Flowchart of patient recruitment. Figure S2: Scheme for time scale in Cox regression analysis to investigate early HCC and late HCC predictors. Figure S3: The cumulative HCC incidences stratified by age ³60 and <60 years (A) in ACLD (B) in non-ACLD Figure S4: The comparisons of the HCC risks within 3 years (early onset) and after 3 years (late onset). (A) DAA group (B) IFN group.

restrictedcc-by-4.0Sep 2024View details →

Clinical Dataset for Risk Factors for Overall Survival in Hospitalized Adults Receiving Total Parenteral Nutrition: A Retrospective Cohort Study at a Social Security Hospital in Peru: January 2022 – June 2023

This Excel dataset contains de-identified clinical data collected over a two-year period, aimed at evaluating risk factors associated with 90-day mortality in hospitalized patients receiving total parenteral nutrition (TPN). The dataset includes variables such as age, sex, clinical diagnosis, comorbidities, days in the ICU, days receiving TPN, laboratory values (lymphocytes, platelets, TGP), and the presence of acute kidney injury (AKI) or chronic kidney disease (CKD). The data is structured in rows, with each row representing an individual patient, and columns corresponding to the various clinical and laboratory parameters. It was used to perform survival analysis using Cox proportional hazards models and other statistical techniques. Sensitive information has been removed to ensure patient confidentiality. Access to the dataset is restricted, and permission must be requested for its use in further research. File format: Excel (.xlsx) Keywords: Total Parenteral Nutrition, 90-Day Mortality, Risk Factors, Clinical Dataset, Cox Regression

Precursors of CVD Risk Factors--Project Heartbeat

ClinicalTrials.gov study NCT00005478. IPD Sharing: Not stated. Countries: 0. Publications: 0.

Change in Coronary Heart Disease Risk Factors in Young Adults

ClinicalTrials.gov study NCT00005406. IPD Sharing: Not stated. Countries: 0. Publications: 0.

Genetic Epidemiology of CVD Risk Factors

ClinicalTrials.gov study NCT00053521. IPD Sharing: Not stated. Countries: 0. Publications: 0.

Anger Expression, Self-focus and Coronary Heart Disease Risk Factors

ClinicalTrials.gov study NCT00005244. IPD Sharing: Not stated. Countries: 0. Publications: 0.

openGEO-OpenSep 2020View details →

Endothelial mutagenesis screen identifies genetic risk factors in the development vascular anomalies

GEO Series GSE137097. Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing.

openGEO-OpenSep 2020View details →

Endothelial mutagenesis screen identifies genetic risk factors in the development vascular anomalies [adipose]

GEO Series GSE137095. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.

openGEO-OpenSep 2020View details →

Endothelial mutagenesis screen identifies genetic risk factors in the development vascular anomalies [muscle]

GEO Series GSE137096. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.

openGEO-OpenJun 2020View details →

miRNAs expression profile in bone marrow-derived PACs during ischemia-induced neovascularization in cardiovascular risk factors conditions

GEO Series GSE151609. Mus musculus. 4 samples. Type: Non-coding RNA profiling by high throughput sequencing.

restrictedMay 2020View details →

Data set from the article Vianello E, Marrocco-Trischitta Massimiliano M, Dozio E, Bandera F, Tacchini L, Canciani E, Dellavia C, Schmitz G, Lorenzo M, Corsi Romanelli Massimiliano M. Correlational study on altered epicardial adipose tissue as a stratification risk factor for valve disease progression through IL-13 signaling. J Mol Cell Cardiol. 2019 Jul;132:210-218. doi: 10.1016/j.yjmcc.2019.05.012. Epub 2019 May 15. Erratum in: J Mol Cell Cardiol. 2019 Aug;133:112. PMID: 31102584.

Data set from the article Vianello E, Marrocco-Trischitta Massimiliano M, Dozio E, Bandera F, Tacchini L, Canciani E, Dellavia C, Schmitz G, Lorenzo M, Corsi Romanelli Massimiliano M. Correlational study on altered epicardial adipose tissue as a stratification risk factor for valve disease progression through IL-13 signaling. J Mol Cell Cardiol. 2019 Jul;132:210-218. doi: 10.1016/j.yjmcc.2019.05.012. Epub 2019 May 15. Erratum in: J Mol Cell Cardiol. 2019 Aug;133:112. PMID: 31102584. This is the abstract: Aims: Genetic and environmental factors all interact in the risk of progression of valvular dysfunctions. Previous studies reported a relation between valve diseases and epicardial adipose tissue (EAT) thickness. The aim of this study was to verify the possible relationship between the molecular pattern of EAT related to IL-13 fibrogenic cytokine expression and valve dysfunction. Methods and results: A valvular heart disease (VHD) population was stratified according to their median EAT thickness (7 mm). The molecular expression of IL-13 in EAT is directly related to the molecular expression of genes associated with extracellular matrix (ECM) turnover, macrophage infiltration and promotion of the formation of ectopic calcific nodules involved in aorta coarctation and calcification. Conclusion: IL-13 gene expression in altered EAT is directly related to the expression of genes involved in ECM turnover and the formation of ectopic calcific nodules, suggesting measurements of EAT as a stratification risk factor for valve instability in the VHD patients.

restrictedNov 2023View details →

Dataset related to article "Comparison of Long-Term Oncological Results in Young Women with Breast Cancer between BRCA-Mutation Carriers Versus Non-Carriers: How Tumor and Genetic Risk Factors Influence the Clinical Prognosis"

This record contains raw data related to article "Comparison of Long-Term Oncological Results in Young Women with Breast Cancer between BRCA-Mutation Carriers Versus Non-Carriers: How Tumor and Genetic Risk Factors Influence the Clinical Prognosis"AbstractBackground: Breast cancer (BC) is very uncommon in young women (YW) and it is unclear whether a BRCA mutation has prognostic implications. Our aim was to evaluate the characteristics of YW with BC by comparing the long-term oncological results between BRCA-mutation carriers and non-carriers.Methods: We retrospectively reviewed all the consecutive YW (aged 18-40 years) diagnosed with BC. Endpoints were disease-free survival (DFS), distant disease-free survival (DDFS), and overall survival (OS).Results: 63 YW with a BRCA mutation were compared with 339 YW without BRCA mutation. BRCA-mutation carriers were younger (60.3% versus 34.8% if age ≤ 35 years, p = 0.001) and presented with more aggressive tumors (66.7% versus 40.7% if G3, p = 0.001; 57.2% versus 12.4% if biological subtype triple-negative, p = 0.001; 73.0% versus 39.2% if Ki67 ≥ 25%, p = 0.001). Non-carriers presented significantly better DFS, DDFS, and OS compared with BRCA-mutation carriers. Neoadjuvant chemotherapy was found to be an independent protective factor for OS in BRCA-mutation carriers.Conclusions: BC is more likely to present at a younger age (≤ 35 years) and with more aggressive characteristics (G3, triple-negative, Ki67 ≥ 25%) in YW with BRCA mutation compared with their non-mutated counterparts. Young BRCA-mutation carriers showed a poorer prognosis in terms of recurrence and survival compared with non-carriers. The implementation of neoadjuvant chemotherapy may improve survival in YW with BC and BRCA mutation.

restrictedcc-by-4.0Nov 2025View details →

Validation of the Spanish Sexual Risk Behaviour Scale (SRBS): Psychosocial factors influencing sexual health risk-taking among adolescents, youth, and future professionals

Open the record for dataset details and reuse information.

restrictedFeb 2022View details →

Dataset related to article "Incidence and risk factors of neurosurgical site infections results of a prospective multicenter cohort study on 6359 surgeries"

taw data related to article at title

restrictedFeb 2020View details →

Cardiovascular Risk Factors Associated With the Metabolically Healthy Obese (MHO) Phenotype Compared to the Metabolically Unhealthy Obese (MUO) Phenotype in Children

Background: In pediatric age the prevalence of obesity is high. Obese children who do not have other risk factors than excess weight have been defined as "metabolically healthy obese" (MHO). Aim: The aim of this study is to evaluate, in a population of obese children, the prevalence of the MHO and "metabolically unhealthy obese" (MUO) phenotype. Furthermore, we evaluated the distribution of Uric Acid, HOMA index and Waist-Height ratio (W-Hr) in the MHO and MUO sub-groups and the impact of these non-traditional risk factors on the probability to be MUO. Methods:In 1201 obese children and adolescents [54% males, age (±SD) 11.9 (±3.0) years] weight, height, waist circumference, systolic (SBP) and diastolic (DBP) blood pressure, pubertal status, glucose, insulin, HDL cholesterol, triglycerides and Uric Acid serum values were assessed. MUO phenotype was defined as the presence of at least one of the following risk factors: SBP or DBP ≥ 90th percentile, glycaemia ≥ 100 mg/dl, HDL cholesterol <40 mg/dl, triglycerides ≥100 mg/dl (children <10 years) or ≥130 mg/dl (children ≥10 years). A multivariate logistic regression analysis was used to estimate the association between MUO phenotype and non-traditional cardiovascular risk factors. Results: The prevalence of the MUO status was high (61%). MUO subjects were more often male, older and pubertal (p < 0.001). The levels of the three non-traditional risk factors were significantly higher in MUO children compared to MHO children (p < 0.001) and all of them were independent predictors of the fact of being MUO [OR 1.41 (95% CI 1.24-1.69); 1.15 (95% CI 1.06-1.23) and 1.03 (95% CI1.01-1.05) for Uric Acid, HOMA index and W-Hr, respectively]. About 15% of MHO subjects had serum Uric Acid, HOMA index and W-Hr values within the highest quartile of the study population. Conclusion: The prevalence of MUO subjects in a large pediatric population is high and serum Uric Acid, HOMA index and W-Hr values are independent predictors of the probability of being MUO. A non-negligible percentage of subjects MHO has high values of all three non-traditional risk factors. <div class="pg-extension"> </div>