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2,285 results for “T-cells”
Vaccination with an HIV T-cell immunogen induces alterations in the mouse gut microbiota
<p>The gut microbiota is emerging as a crucial factor modulating vaccine responses; however, few studies have investigated if vaccines, in turn, can alter the microbiota and to what extent such changes may boost vaccine efficacy. To understand the effect of T-cell vaccination on the gut microbiome, we administered an HIV-1 T-cell immunogen (HTI arm) or PBS (control) to C57Bl/6 mice following a heterologous prime-boost scheme. The longitudinal dynamics of the mice gut microbiota were characterized by 16S ribosomal RNA sequencing in fecal samples collected from cages, as well as from three gut sections (caecum, small and large intestine). Serum and spleen cells were obtained at the study endpoint to assess immune correlates using IFNγ ELISPOT and cytokine Luminex<sup>®</sup> assays. Compared with PBS, HTI vaccination increased several <em>Clostridiales </em>genera associated with anti-inflammatory responses, such as <em>Eubacterium xylanophilum </em>group, <em>Roseburia</em> and <em>Ruminococcus</em>. Such shifts were observed after the first HTI dose and remained throughout the study follow-up (18 weeks). Hoverer, the specifically enriched <em>Clostridiales</em> genera were different between feces and gut sections. The abundance of HTI-enriched bacteria positively correlated with the magnitude of vaccine-induced responses and a set of pro-inflammatory cytokines, especially IL-6. This longitudinal analysis reveals that, in mice, T-cell vaccination promotes the increase of anti-inflammatory gut bacteria in parallel to significant associations with proinflammatory cytokines, suggesting an adaptation of the gut microbial milieu to T-cell-induced systemic inflammation.</p>
Predicting SARS-CoV-2 exposure using T-cell repertoire sequencing and machine learning
<p>The dataset contains processed T-cell receptor repertoire sequencing data from >1200 individuals of different sex and age, originally published in [1]. Note that only samples with good sequencing coverage are published (>10^5 reads per file). </p> <p>TODO</p>
Gabriella Miller Kids First Pediatric Research Program in Pediatric T-Cell Acute Lymphoblastic Leukemia
Open the record for dataset details and reuse information.
Identification and Targeting of Treatment Resistant Progenitor Populations in T-cell Acute Lymphoblastic Leukemia
Open the record for dataset details and reuse information.
Comprehensive Genomic Profiling to Improve Prediction of Clinical Outcome for Children with T-cell Acute Lymphoblastic Leukemia
Namespace hosted on the Kids First DRC FHIR services at fhir.kidsfirstdrc.org
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.