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Figure 6 in Evaluation of nickel-induced brain injuries in rats via oxidative stress and apoptosis: attenuating effects of hyperoside
Figure 6. (A) Neurons of brain tissue of control group (arrows). (B) Mild positive signs in neurons of Hyp-treated group (arrows). (C) Severe positive signs in neurons of Ni-treated group (arrows). (D) Mild positive signs in neurons of Ni + Hyptreated group (arrows) (IF, 20 µm).
Figure 2 in Investigation of the effect of silymarin on oxidative DNA damage and inflammatory markers in ischemia/reperfusion injury following experimental testicular torsion/detorsion in rats
Figure 2. Testicular tissue, control group, negative Tnf-α expression (A). T 3 h / D 3 h group: very severe Tnf-α expression in the perivascular and intertubular intervals (arrowheads) (B). T 3 h / D 24 h group: severe Tnf-α expression in the perivascular and intertubular intervals (arrowheads) (C). T 3 h / D 3 h + silymarin group: medium level Tnf-α expression in the perivascular and intertubular intervals (arrowheads) (D). T 3 h / D 24 h + silymarin group: mild Tnf-α expression in the perivascular and intertubular intervals (arrowheads) (E). IHC-P, bar: 50 µm.
Figure 1 in Investigation of the effect of silymarin on oxidative DNA damage and inflammatory markers in ischemia/reperfusion injury following experimental testicular torsion/detorsion in rats
Figure 1. Testicular tissue, control group, normal histological view (A). T 3 h / D 3 h group: necrosis in spermatocytes (arrowheads); severe congestion in intertubular intervals (thick arrows); hemorrhage, thinning in the tubulus wall (B). T 3 h / D 24 h: necrosis in spermatocytes (arrowheads); severe edema in the intertubular space (stars); thinning of the tubulus wall (C). T 3 h / D 3 h + silymarin group: moderate edema in the intertubular intervals (star); congestion (thick arrow) (D). T 3 h / D 24 h + silymarin group: mild edema at intertubular intervals (star) (E); H and E, bar: 50 µm.
Figure 3 in Investigation of the effect of silymarin on oxidative DNA damage and inflammatory markers in ischemia/reperfusion injury following experimental testicular torsion/detorsion in rats
Figure 3. Testicular tissue, control group, negative 8-OHdG expression (A). T 3 h / D 3 h group: severe cytoplasmic 8-OHdG expression in spermatocytes (arrowheads) (B). T 3 h / D 24 h group: severe cytoplasmic 8-OHdG expression in spermatocytes (arrowheads) (C). T 3 h / D 3 h + silymarin group: moderate cytoplasmic 8-OHdG expression in spermatocytes (arrowheads) (D). T 3 h / D 24 h + silymarin group: mild cytoplasmic 8-OHdG expression in spermatocytes (E), IHC-P, bar: 50 µm.
MassSpectrometry Dataset to "Mitochondrial Creatine Kinase 2 (Ckmt2) as a Plasma-Based Biomarker for Evaluating Reperfusion Injury in Acute Myocar-dial Infarction"
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Effects of Kalimeris indica on alcohol-induced liver injury
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"Quacking for Noggin": Farm Animal–Assisted Therapy for Traumatic Brain Injury Survivors
<p>The aim of this study was to examine the effects of animal-assisted therapies with farm animals (AATF), in this case domesticated ducks, on depression, anxiety, and self-efficacy in patients with traumatic brain injury (TBI). Furthermore, the following hypothesis was tested: Engaging in AATF with domesticated ducks will be associated with decreased depression, decreased anxiety, and increased self-efficacy. The study examined the effects of AATF on anxiety, depression, and self-efficacy among nine patients with TBI. A time series quasi-experimental design was utilized. Participants completed the Hospital Anxiety and Depression Survey (HADS) and General Self-Efficacy (GSE) questionnaires at baseline, followed by the AAFT intervention. The AAFT intervention consisted of two one-hour sessions interacting with ducks every week for 12 weeks. Participants repeated baseline measures immediately following the intervention, and again four weeks post intervention to evaluate the residual effects of the intervention. A general linear model was employed to examine changes in anxiety, depression, and selfefficacy. Participants’ anxiety scores decreased significantly from baseline to post intervention measure (p = .009); however, there were no statistically significant differences between anxiety levels immediately post intervention and four weeks later. There were no statistically significant differences in depression or self-efficacy levels at pre-, post-, and retest. Our study hypothesis was partially supported in that statistically significant decreases in anxiety were observed from baseline to immediate posttest. Mastery of skills, vicarious experiences, and verbal persuasion may be the factors that contributed to the beneficial outcomes of the interactions between persons with TBI and domesticated ducks</p>
EMG decoding from Spinl Cord Injury patients task video
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Dataset related to "Translational approach to assess brain injury after cardiac arrest in preclinical models: a narrative review"
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Dataset related to article "Mapping Brain Small Metabolite Changes After Traumatic Brain Injury using AP-MALDI MSI"
<p>Raw data for figures 2,3 and 4 regarding mass spectrometry imaging dataset</p>
Trajectory Based Classification of Recovery In Sensorimotor Complete Traumatic Cervical Spinal Cord Injury – Individual Recovery Trajectory Data
<p><b>Objective</b></p> <p>To test the hypothesis that sensorimotor complete traumatic cervical spinal cord injury is a heterogenous clinical entity comprising several subpopulations that follow fundamentally different trajectories of neurological recovery.</p> <p><b>Methods</b></p> <p>We analyzed demographic and injury data from 655 patients who were pooled from four prospective longitudinal multicenter studies. Group based trajectory modeling was applied to model neurological recovery trajectories over the initial 12-months postinjury and to identify predictors of recovery trajectories. Neurological outcomes included: Upper Extremity Motor Score, Total Motor Scores and AIS grade improvement.</p> <p><b>Results </b></p> <p>The analysis identified three distinct trajectories of neurological recovery. These clinical courses included: (1) Marginal recovery trajectory: characterized by minimal or no improvement in motor strength or change in AIS grade status (remained grade A); (2) Moderate recovery trajectory: characterized by low baseline motor scores that improved approximately 13 points; or AIS conversion of one grade point; (3) Good recovery trajectory: characterized by baseline motor scores in the upper quartile that improved to near maximum values within three months of injury. Patients following the moderate or good recovery trajectories were of younger age, had more caudally located injuries, a higher degree of preserved motor and sensory function at baseline examination and exhibited a greater extent of motor and sensory function in the zone of partial preservation.</p> <p><b>Conclusion</b></p> <p>Cervical complete SCI can be classified into one of three distinct subpopulations with fundamentally different trajectories of neurological recovery. This study defines unique clinical phenotypes based on potential for recovery, rather than baseline severity of injury alone. This approach may prove beneficial in clinical prognostication and in the design and interpretation of clinical trials in SCI.</p>
Head injuries, traumas, and neuropsychiatric sequela in asylum seekers
<p><b>Importance: </b>Asylum seekers experience a high burden of physical and psychological trauma, yet there is a scarcity of literature regarding the epidemiology and sequelae of head injury (HI) in asylum seekers.</p> <p><b>Objective: </b>To examine head injury prevalence and related neuropsychiatric comorbidities in asylum seekers.</p> <p><b>Methods: </b>A<b> </b>retrospective cross-sectional study through review of 139 medical affidavits from an affidavit database was performed. Affidavits written from 2010 – 2018 were included. Demographic and case-related data were collected and classified based on the presence of head injury. <a>Primary study outcome measurement was prevalence of head injury and headache. Secondary outcomes included the neuropsychiatric sequelae of head injury including depression, PTSD, anxiety, memory/concentration deficits, and the prevalence of abusive and traumatic history. Hypothesis and outcome measures were determined before data extraction.</a></p> <p><b>Results: </b>One hundred and thirty-nine medical affidavits of asylum seekers were included in the study. The mean age was 27.4±12.1, 56.8% identified as female, 28.1% were <18 years. Almost half (42.5%) explicitly self-reported history of head injury. Compared to clients who did not report head injury, clients with head injury were older (31.4 vs 24.4, 7.0 year difference; 95%CI [2.9, 10.9 years]) and more likely to report a history of headache (62.7% vs 28.8%, 33.9% difference; 95%CI [20.0, 47.8%], p<.001), physical abuse (91.5% vs 65.0%, 26.5% difference; 95%CI [12.8, 38.5%];), physical trauma (96.6% vs 66.3%, 30.4% difference; 95%CI [17.9, 41.5%]), concussion (22.0% vs 0.0%, 22% difference; 95%CI [12.2, 34.1%]), and loss of consciousness (27.1% vs 0.0%, 27.1% difference; 95%CI [16.4, 39.6%]). Moreover, clients with head injuries were more likely to suffer neuropsychological sequelae such as memory/concentration deficits (45.8% vs 28.8%, 17.0% difference; 95%CI [0.8, 33.2%]), and depression (83.1% vs 65%, 18.1% difference; 95%CI [3.0, 33.2%]).</p>
Data from: Human-relevant mechanisms and risk factors for TAK-875-induced liver injury identified via a gene pathway-based approach in collaborative cross mice
<p>Development of TAK-875 was discontinued when a small number of serious drug-induced liver injury (DILI) cases were observed in Phase 3 clinical trials. Subsequent studies have identified hepatocellular oxidative stress, mitochondrial dysfunction, altered bile acid homeostasis, and immune response as mechanisms of TAK-875 DILI and the contribution of genetic risk factors in oxidative response and mitochondrial pathways to the toxicity susceptibility observed in patients. We tested the hypothesis that a novel preclinical approach based on gene pathway analysis in the livers of Collaborative Cross mice could be used to identify human-relevant mechanisms of toxicity and genetic risk factors at the level of the hepatocyte as reported in a human genome-wide association study. Eight (8) male mice (4 matched pairs) from each of 45 Collaborative Cross lines were treated with a single oral (gavage) dose of either vehicle or 600 mg/kg TAK-875. As expected, liver injury was not detected histologically and few changes in plasma biomarkers of hepatotoxicity were observed. However, gene expression profiling in the liver identified hundreds of transcripts responsive to TAK-875 treatment across all strains reflecting alterations in immune response and bile acid homeostasis and the interaction of treatment and strain reflecting oxidative stress and mitochondrial dysfunction. Fold-change expression values were then used to develop pathway-based phenotypes for genetic mapping which identified candidate risk factor genes for TAK-875 toxicity susceptibility at the level of the hepatocyte. Taken together, these findings support our hypothesis that a gene pathway-based approach using Collaborative Cross mice could inform sensitive strains, human-relevant mechanisms of toxicity, and genetic risk factors for TAK-875 DILI. This novel preclinical approach may be helpful in understanding, predicting, and ultimately preventing clinical DILI for other drugs.</p>
Datasets and R source code of manuscript "Adding insult to injury: anthropogenic noise intensifies predation risk by an invasive freshwater fish species" by Fernandez Declerck et al.
<p>Datasets and R source code of manuscript "Adding insult to injury: anthropogenic noise intensifies predation risk by an invasive freshwater fish species" by Fernandez Declerck et al. (submitted)</p> <p> Project<br> ├── README<br> ├── data_functional_response.txt<br> ├── data_prey_behaviour.txt<br> ├── R_script.R<br> └── BINV-D-22-00447_Playback.wav</p> <p>Main dataset: 'data_functional_response.txt'. Dataset for the functional response of the predator. Fish behaviour was recorded under two noise conditions (either boat noise or ambient noise). The dataset corresponds to data frame "d" in the script. Variables description:<br> - id: identity of the fish<br> - condition: noise condition, either "boat noise" or "ambient noise"<br> - prey_number: number of chironomid larvae introduced in the tank<br> - prey_captured : number of chironomid larvae consumed<br> - fish_mass : fish body mass (g)<br> - swim_distance: swim distance (m)</p> <p>Secondary dataset: 'data_prey_behaviour.txt'. Dataset for control experiment on prey behaviour. Prey behaviour was recorded under two noise conditions (either boat noise or ambient noise). The dataset corresponds to data frame "f" in the script. We used 20 replicates with 10 replicates for ambient noise condition, and 10 replicates for boat noise condition. Two focal prey larva were observed per replicates. Each prey larva was observed during two time periods (corresponding to two noise sequences). Variables description:<br> - condition: noise condition, either "boat noise" or "ambient noise"<br> - replicate: number of the replicate<br> - unique_id: identity of each focal larva<br> - noise_sequence: number of the noise sequence (either second or third)<br> - prop_inactive: proportion of time spent inactive by the focal larva<br> - prop_active: proportion of time spent active by the focal larva</p> <p>R source code 'code R_script.R'. Complete analysis as one single R script. See comments for additional information.</p> <p>The last file `BINV-D-22-00447_Playback.wav` is an audio file (Waveform Audio File Format). It is the soundtrack used in the playback experiments.</p>
Dataset related to article "A novel organotypic cortical slice culture model for traumatic brain injury: molecular changes induced by injury and mesenchymal stromal cell secretome treatment"
<p>Dataset related to manuscript "A novel organotypic cortical slice culture model for traumatic brain injury: molecular changes induced by injury and mesenchymal stromal cell secretome treatment"</p> <p>Each excel file contains raw data relative to data shown in Figures</p>
raw data statistics article "Chemotaxis of Tuta absoluta to tomato plants exposed to methyl jasmonate and conspecific injuries"
<p>raw data statistics article "Chemotaxis of Tuta absoluta to tomato plants exposed to methyl jasmonate and conspecific injuries"</p>
Fig. 4. X in Diverse lignans with protective effect against hypoxia/oxidative injuries to H9c2 cells from Syringa pinnatifolia Hemsl.
Fig. 4. X-ray crystallographic ORTEP diagram of 3.
Fig. 5 in Diverse lignans with protective effect against hypoxia/oxidative injuries to H9c2 cells from Syringa pinnatifolia Hemsl.
Fig. 5. The key NOESY correlations of 4 and 6.
Fig. 1 in Diverse lignans with protective effect against hypoxia/oxidative injuries to H9c2 cells from Syringa pinnatifolia Hemsl.
Fig. 1. The chemical structures of 1–10.
Fig. 6 in Diverse lignans with protective effect against hypoxia/oxidative injuries to H9c2 cells from Syringa pinnatifolia Hemsl.
Fig. 6. Calculated and experimental ECD spectra of 6–8 and 10.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.