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2,470
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Dataset results
2,470 results for “Acute Myeloid Leukemia”
Histone demethylase KDM4A-mediated promotion of PAF1/NFATC2 expression is required for oncogenesis in MLL-AF9 acute myeloid leukemia [RNA-seq]
GEO Series GSE125374. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Genomic profiles and survival prognosticators in African-American patients with acute myeloid leukemia
GEO Series GSE266498. Homo sapiens. 13 samples. Type: Expression profiling by high throughput sequencing; Other.
High expression of circZBTB46 predicts poor prognosis in patients with myelodysplastic syndrome and acute myeloid leukemia
GEO Series GSE163386. Homo sapiens. 14 samples. Type: Non-coding RNA profiling by array.
Oncogenic Kras synergizes with enhanced TGF-beta-Foxd4 signaling to maintain leukemia-initiating cells in acute myeloid leukemia
GEO Series GSE107326. Mus musculus. 2 samples. Type: Expression profiling by array.
Genome-wide maps of chromatin remodeler binding in acute myeloid leukemia cell line.
GEO Series GSE125310. Homo sapiens. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Differential expression of miRNAs in acute myeloid leukemia quantified by NGS of whole blood samples
GEO Series GSE128079. Homo sapiens. 19 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Co-expression of microrna and mrna in cytogenetically normal acute myeloid leukemia patients [miRNA]
GEO Series GSE142699. Homo sapiens. 48 samples. Type: Non-coding RNA profiling by array.
Adhesion GPCR ADGRE2 maintains proteostasis to promote progression in acute myeloid leukemia
GEO Series GSE261574. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Acute myeloid leukemia with mixed phenotype is characterized by stemness features with limited lineage plasticity
GEO Series GSE275859. Homo sapiens. 20 samples. Type: Expression profiling by high throughput sequencing.
A Novel Acute Erythroleukemia Cell Line Derived from Ascitic Fluid in a Patient with Congenital Acute Myeloid Leukemia
GEO Series GSE264669. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing; Other.
Fatty acid metabolism mediates venetoclax resistance in acute myeloid leukemia stem cells
GEO Series GSE156008. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
Dormant leukemia stem cells reinforced by chemotherapy drive early treatment failure in acute myeloid leukemia patients [scRNA_PT]
GEO Series GSE185991. Homo sapiens. 42 samples. Type: Expression profiling by high throughput sequencing.
Acute Myeloid Leukemia (AML)
The TARGET Acute Myeloid Leukemia projects elucidate comprehensive molecular characterization to determine the genetic changes that drive the initiation and progression of high-risk or hard-to-treat childhood cancers. Acute myeloid leukemia (AML) is a cancer that originates in the bone marrow from immature white blood cells known as myeloblasts. About 25% of all children with leukemia have AML.
Acute Myeloid Leukemia OHSU
Whole-exome and transcriptomic sequencing of 942 acute myeloid leukemia samples (with 500 matched normals) from the Beat AML program. The cases here are only those under the age of 40 years old.
Pediatric Acute Myeloid Leukemia
Molecular profiling of 887 pediatric acute myeloid leukemia cases and their matched normals using RNA-Seq, WES, and WGS.
Detection and Targeting of Splicing Deregulation in Pediatric Acute Myeloid Leukemia Stem Cells
This study evaluates the gene expression and splicing changes between pediatric patients with and without Acute Myeloid Leukemia (AML) and pediatric and adult patients with AML. We obtained bone marrow or peripheral blood from patients and isolated CD34+ stem and/or progenitor cells from pediatric patients with AML (10) or without AML (6) and adult patients with AML (5). In parallel, a targeted analysis for known, deleterious, genetic mutations in the KRAS, NRAS, and KMT2C genes identified 2, 5, and 6 AML patients with alterations, respectively. Additionally, Tapestri analysis further identified a mutation in the intronic region of the SF3B1 gene in multiple pediatric AML patients. RNA-Seq was performed on the purified cell populations at The Scripps Research Institute Next Generation Core on an Illumina NextSeq 500 sequencer with 150bp paired-end reads. These datasets revealed that, similar to adult AML, pediatric AML samples were enriched for Leukemia Stem Cells (LSC) markers. A deeper analysis showed widespread dysregulation of splicing in pediatric AML samples compared to age-matched non-leukemic samples. In addition, the splicing regulator RBFOX2 was downregulated with an accompanying increase in specific CD47 splice isoforms in the pediatric AML samples. Thus, the increased presence of LSCs in pediatric AML is possibly driven by global splicing deregulation, and the treatment with splicing modulators like Rebecsinib has a potential therapeutic value for eradicating LSCs in these patients.
TARGET: Acute Myeloid Leukemia (AML)
Open the record for dataset details and reuse information.
Deconvolution of drug screening data delineates drug sensitivity of stem-like cancer cells in Acute Myeloid Leukemia [RNA-Seq]
GEO Series GSE217919. Homo sapiens. 10 samples. Type: Expression profiling by high throughput sequencing.
Single-cell dissection reveals promotive role of ENO1 in leukemia stem cell self-renewal and chemoresistance in acute myeloid leukemia
<p><span>Quiescent s</span><span>elf-renew</span><span>al</span><span> </span><span>of </span><span>leukemia stem cells (LSCs)</span><span> and resistance to</span><span> </span><span>c</span><span>onventional chemotherapy </span><span>are the main factors leading to relapse of acute myeloid leukemia (AML). </span><span>Alpha-enolase (<em>ENO1</em>), a key glycolytic enzyme, has been shown to regulate embryonic stem cell differentiation and promote self-renewal and malignant phenotypes in various cancer stem cells. Here, we sought to test whether and how <em>ENO1</em> influences LSCs renewal and chemoresistance within the context of AML.</span></p> <p><span>We analyzed single-cell RNA sequencing data from bone marrow samples of 8 relapsed/refractory AML patients and 4 healthy controls using bioinformatics and machine learning algorithms. In addition, we compared <em>ENO1</em> expression levels in the AML cohort with those in 37 control subjects and conducted survival analyses to correlate <em>ENO1</em> expression with clinical outcomes. Furthermore, we performed functional studies involving <em>ENO1</em> knockdown and inhibition in AML cell line(MOLM_13).</span></p>
Donor Stem Cell Transplant in Treating Patients With Acute Myeloid Leukemia in Remission
ClinicalTrials.gov study NCT00101140. IPD Sharing: Not stated. Countries: 0. Publications: 0.
ScienceDex guides
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.