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291
datasets available to search
ShareScore release 0.9.0
Dataset results
291 results for “C57BL/6J”
Virus-Induced Airway Disease in Mice (C57BL/6J, d21/d49)
GEO Series GSE10964. Mus musculus. 18 samples. Type: Expression profiling by array.
LAKTP_MTO orthotopic primary caecum tumours from Galunisertib-treated C57BL/6J mice
GEO Series GSE103562. Mus musculus. 20 samples. Type: Expression profiling by array.
Expression profiling of Brain tissue from C57BL/6J X C3H/HeJ)F2 and (C3H/HeJ X C57BL/6J)F2
GEO Series GSE12798. Mus musculus. 292 samples. Type: Expression profiling by array.
Gene expression data from C57BL/6J mice exposed to 3 days of hypoxia
GEO Series GSE244830. Mus musculus. 12 samples. Type: Expression profiling by array.
Comparative analysis of gene expression in C57BL/6J and DBA/2J aging lungs.
GEO Series GSE6591. Mus musculus. 15 samples. Type: Expression profiling by array.
Next Generation Sequencing Comparison of C57BL/6J and BC027072 -/- Eye Transcriptomes
GEO Series GSE63810. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
37-Day microgravity exposure in 16-Week female C57BL/6J mice during the NASA Rodent Research 1 mission is associated with bone loss specific to weight-bearing skeletal sites (femur and vertebrae, micro computed tomography)
Exposure to weightlessness in microgravity and elevated space radiation are associated with rapid bone loss in mammals, but questions remain about their mechanisms of action and relative importance. In this study, we tested the hypothesis that bone loss during spaceflight in Low Earth Orbit is primarily associated with site-specific microgravity unloading of weight-bearing sites in the skeleton. Microcomputed tomography and histological analyses of bones from mice space flown on ISS for 37 days in the NASA Rodent Research-1 experiment show significant site-specific cancellous and cortical bone loss occurring in the femur, but not in L2 vertebrae. The lack of bone degenerative effects in the spine in combination with same-animal paired losses in the femur suggests that space radiation levels in Low Earth Orbit or other systemic stresses are not likely to significantly contribute to the observed bone loss. Remarkably, spaceflight is also associated with accelerated progression of femoral head endochondral ossification. This suggests the microgravity environment promotes premature progression of secondary ossification during late stages of skeletal maturation at 21 weeks. Furthermore, mice housed in the NASA ISS Rodent Habitat during 1g ground controls maintained or gained bone relative to mice housed in standard vivarium cages that showed significant bone mass declines. These findings suggest that housing in the Rodent Habitat with greater topological enrichment from 3D wire-mesh surfaces may promote increased mechanical loading of weight-bearing bones and maintenance of bone mass. In summary, our results indicate that in female mice approaching skeletal maturity, mechanical unloading of weight-bearing sites is the major cause of bone loss in microgravity, while sites loaded predominantly by muscle activity, such as the spine, appear unaffected. Additionally, we identified early-onset of femoral head epiphyseal plate secondary ossification as a novel spaceflight skeletal unloading effect that may lead to premature long bone growth arrest in microgravity. This study derives results from femur and vertebrae using the micro computed tomography assay.
Effects of low-dose oxygen ions and protons on cardiac function and structure in male C57BL/6J mice (western blot, histology, and immunohistochemistry)
Purpose: Astronauts traveling beyond low Earth orbit will be exposed to high linear energy transfer charged particles. Because there is concern about the adverse effects of space radiation on the cardiovascular system, this study assessed cardiac function and structure and immune cell infiltration in a mouse model of charged particle irradiation. Materials and methods: Male C57BL/6 J mice were exposed to oxygen ions (16O, 600 MeV/n at 0.25 to 0.26 Gy/min to a total dose of 0, 0.05, 0.1, 0.25, or 1 Gy), protons (150 MeV, 0.35 to 0.55 Gy/min to 0, 0.5, or 1 Gy), or protons (150 MeV, 0.5 Gy) followed by 16O (600 MeV/n, 0.1 Gy). Separate groups of mice received 137Cs γ rays (1 Gy/min to 0, 0.5, 1, or 3 Gy) as a reference. Cardiac function and blood velocity were measured with ultrasonography at 3, 5, 7, and 9 months after irradiation. At 2 weeks, 3 months, and 9 months, cardiac tissue was collected to assess apoptosis, tissue remodeling, and markers of immune cells. Results: Ejection fraction and fractional shortening decreased at 3 and 7 months after 16O. These parameters did not change in mice exposed to γ rays, protons, or protons followed by 16O. Each of the radiation exposures caused only small increases in cleaved caspase3 and numbers of apoptotic nuclei. Changes in the levels of α smooth muscle cell actin and a 75kDa peptide of collagen type III in the left ventricle suggested tissue remodeling, but there was no significant change in total collagen deposition at 2 weeks, 3 months, and 9 months. Increases in protein amounts of cluster of differentiation (CD)2, CD68, and CD45 as measured with immunoblots at 2 weeks, 3 months, and 9 months after exposure to protons or 16O alone suggested immune cell infiltration. For type III collagen, CD2 and CD68, the efficacy in inducing protein abundance of CD2, CD68, and CD45 was 16O greater than protons was greater than γ rays greater than protons followed by 16O. Conclusions: Low dose, high energy charged particle irradiation caused mild changes in cardiac function and tissue remodeling in the mouse. This dataset derives result from the western blot, histology, and immunohistochemistry assays.
Effects of low-dose oxygen ions and protons on cardiac function and structure in male C57BL/6J mice (echocardiogram/ultrasonography)
Purpose: Astronauts traveling beyond low Earth orbit will be exposed to high linear energy transfer charged particles. Because there is concern about the adverse effects of space radiation on the cardiovascular system, this study assessed cardiac function and structure and immune cell infiltration in a mouse model of charged particle irradiation. Materials and methods: Male C57BL/6 J mice were exposed to oxygen ions (16O, 600 MeV/n at 0.25 to 0.26 Gy/min to a total dose of 0, 0.05, 0.1, 0.25, or 1 Gy), protons (150 MeV, 0.35 to 0.55 Gy/min to 0, 0.5, or 1 Gy), or protons (150 MeV, 0.5 Gy) followed by 16O (600 MeV/n, 0.1 Gy). Separate groups of mice received 137Cs γ rays (1 Gy/min to 0, 0.5, 1, or 3 Gy) as a reference. Cardiac function and blood velocity were measured with ultrasonography at 3, 5, 7, and 9 months after irradiation. At 2 weeks, 3 months, and 9 months, cardiac tissue was collected to assess apoptosis, tissue remodeling, and markers of immune cells. Results: Ejection fraction and fractional shortening decreased at 3 and 7 months after 16O. These parameters did not change in mice exposed to γ rays, protons, or protons followed by 16O. Each of the radiation exposures caused only small increases in cleaved caspase3 and numbers of apoptotic nuclei. Changes in the levels of α smooth muscle cell actin and a 75kDa peptide of collagen type III in the left ventricle suggested tissue remodeling, but there was no significant change in total collagen deposition at 2 weeks, 3 months, and 9 months. Increases in protein amounts of cluster of differentiation (CD)2, CD68, and CD45 as measured with immunoblots at 2 weeks, 3 months, and 9 months after exposure to protons or 16O alone suggested immune cell infiltration. For type III collagen, CD2 and CD68, the efficacy in inducing protein abundance of CD2, CD68, and CD45 was 16O greater than protons was greater than γ rays greater than protons followed by 16O. Conclusions: Low dose, high energy charged particle irradiation caused mild changes in cardiac function and tissue remodeling in the mouse. This dataset derives result from the cardiac ultrasound and abdominal aorta doppler (echocardiography) assays.
RNA sequencing of MC38 tumor cells from control-diet- and high-fat-diet-fed C57BL/6J mice
GEO Series GSE274825. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
Effect of depletion of Prrc2b on gene expression during oligodendrocyte development in isloated oligodendrocyte progenitor cells of C57BL/6J mice
GEO Series GSE222395. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Multi-tissue expression profiling of TALLYHO/Jng and C57BL/6J Mice under high-fat and chow diets
GEO Series GSE234011. Mus musculus. 399 samples. Type: Expression profiling by high throughput sequencing.
Gene expression in diet-induced obesity resistent (DIO non-responder) and diet-induced obesity susceptible (DIO responder) C57BL/6J mouse strain
GEO Series GSE74542. Mus musculus. 20 samples. Type: Expression profiling by array.
SM015 - Infection with SARS MA15 of C57BL/6J mice and Tnfrsf1a/1b knockouts
GEO Series GSE40840. Mus musculus. 20 samples. Type: Expression profiling by array.
Spatial landscapes of the fed, fasted and refed livers from C57BL/6J mice - spatial transcriptomics
GEO Series GSE222796. Mus musculus. 3 samples. Type: Other.
Gene expression profile at single cell level of peripheral blood mononuclear cells from Cx3cr1-/- mice and wt mice under C57BL/6J background
GEO Series GSE282569. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Effect of Insulin receptor deletion in hepatocytes on liver gene expression at three distinct time points in male mice (C57BL/6J) fed ad libitum a chow diet
GEO Series GSE165154. Mus musculus. 36 samples. Type: Expression profiling by array.
Gene expression profile at single cell level of Lineage- Sca1+ c-Kit+ cells (LSKs) from the bone marrow of normal C57BL/6J mice with or without 5.0 Gy total body irradiation.
GEO Series GSE221907. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic signatures of spleen and liver CD4+ T cells from Leishmania donovani-infected C57BL/6J mice
GEO Series GSE135857. Mus musculus. 19 samples. Type: Expression profiling by array.
Transcriptome change mediated by tumor-intrinsic PRC2 inactivation in transplant murine breast cancer AT3 tumor model in C57BL/6J mice
GEO Series GSE179703. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
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